Výsledky vyhledávání - "Nadia, Arang"

Akademický článek

Systems modeling of oncogenic G-protein and GPCR signaling reveals unexpected differences in downstream pathway activation

Autor: Michael Trogdon, Kodye Abbott, Nadia Arang, Kathryn Lande, Navneet Kaur, Melinda Tong, Mathieu Bakhoum, J. Silvio Gutkind, Edward C. Stites

Publikováno v: npj Systems Biology and Applications, Vol 10, Iss 1, Pp 1-17 (2024)

Abstract Mathematical models of biochemical reaction networks are an important and emerging tool for the study of cell signaling networks involved in disease processes. One promising potential application of such mathematical models is the study of h

Externí odkaz: https://doaj.org/article/0b29339706f74b9f85438ba20cdd4062

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Akademický článek

Focal Adhesion Kinase (FAK)-Hippo/YAP transduction signaling mediates the stimulatory effects exerted by S100A8/A9-RAGE system in triple-negative breast cancer (TNBC)

Autor: Damiano Cosimo Rigiracciolo, Nijiro Nohata, Rosamaria Lappano, Francesca Cirillo, Marianna Talia, Sendi Rafael Adame-Garcia, Nadia Arang, Simone Lubrano, Ernestina Marianna De Francesco, Antonino Belfiore, J. Silvio Gutkind, Marcello Maggiolini

Publikováno v: Journal of Experimental & Clinical Cancer Research, Vol 41, Iss 1, Pp 1-25 (2022)

Abstract Background Understanding the intricate signaling network involved in triple-negative breast cancer (TNBC) represents a challenge for developing novel therapeutic approaches. Here, we aim to provide novel mechanistic insights on the function

Externí odkaz: https://doaj.org/article/a3564ce5716f47f8b9003093ea7bbf6e

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Akademický článek

EGFR Regulates the Hippo pathway by promoting the tyrosine phosphorylation of MOB1

Autor: Toshinori Ando, Nadia Arang, Zhiyong Wang, Daniela Elena Costea, Xiaodong Feng, Yusuke Goto, Hiroki Izumi, Mara Gilardi, Kazuyo Ando, J. Silvio Gutkind

Publikováno v: Communications Biology, Vol 4, Iss 1, Pp 1-15 (2021)

Ando et al show in head and neck squamous cell carcinoma cells that EGFR activation leads to the phosphorylation of the Hippo pathway component, MOB1 to inhibit LATS1/2 function resulting in YAP/TAZ activation. Further, EGFR-targeting therapies suppr

Externí odkaz: https://doaj.org/article/33b5d7dcaf814e90908b2ebbb399a0ea

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Akademický článek

Identifying host regulators and inhibitors of liver stage malaria infection using kinase activity profiles

Autor: Nadia Arang, Heather S. Kain, Elizabeth K. Glennon, Thomas Bello, Denali R. Dudgeon, Emily N. F. Walter, Taranjit S. Gujral, Alexis Kaushansky

Publikováno v: Nature Communications, Vol 8, Iss 1, Pp 1-9 (2017)

Host kinases facilitate Plasmodium liver stage (LS) infection, but systematic accounting of important players is lacking. Here, the authors use a computational approach and kinase activity profiles to identify host kinase regulators of LS infection a

Externí odkaz: https://doaj.org/article/34b30dc350304d7da86e97eaeab203a7

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Akademický článek

Alterations in Phosphorylation of Hepatocyte Ribosomal Protein S6 Control Plasmodium Liver Stage Infection

Autor: Elizabeth K.K. Glennon, Laura S. Austin, Nadia Arang, Heather S. Kain, Fred D. Mast, Kamalakannan Vijayan, John D. Aitchison, Stefan H.I. Kappe, Alexis Kaushansky

Publikováno v: Cell Reports, Vol 26, Iss 12, Pp 3391-3399.e4 (2019)

Summary: Plasmodium parasites are highly selective when infecting hepatocytes and induce many changes within the host cell upon infection. While several host cell factors have been identified that are important for liver infection, our understanding

Externí odkaz: https://doaj.org/article/26839600807547f498e38d3107d86864

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