Tento výsledek nelze pro nepřihlášené uživatele zobrazit.
K zobrazení výsledku je třeba se přihlásit.

Structure-function analyses of human TRPV6 ancestral and derived haplotypes.

Autor: Neuberger A; Department of Biochemistry and Molecular Biophysics, Columbia University, New York, NY 10032, USA., Shalygin A; Walther-Straub Institute of Pharmacology and Toxicology, LMU Munich, 80336 Munich, Germany., Trofimov YA; Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, 117997 Moscow, Russia., Veretenenko II; Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, 117997 Moscow, Russia., Nadezhdin KD; Department of Biochemistry and Molecular Biophysics, Columbia University, New York, NY 10032, USA., Krylov NA; Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, 117997 Moscow, Russia., Gudermann T; Walther-Straub Institute of Pharmacology and Toxicology, LMU Munich, 80336 Munich, Germany; Comprehensive Pneumology Center, German Center for Lung Research, 81377 Munich, Germany., Efremov RG; Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, 117997 Moscow, Russia; National Research University Higher School of Economics, 101000 Moscow, Russia., Chubanov V; Walther-Straub Institute of Pharmacology and Toxicology, LMU Munich, 80336 Munich, Germany., Sobolevsky AI; Department of Biochemistry and Molecular Biophysics, Columbia University, New York, NY 10032, USA. Electronic address: as4005@cumc.columbia.edu.

Publikováno v: Structure (London, England : 1993) [Structure] 2024 Oct 28. Date of Electronic Publication: 2024 Oct 28.

Kainate receptor channel opening and gating mechanism.

Autor: Gangwar SP; Department of Biochemistry and Molecular Biophysics, Columbia University, New York, NY, USA., Yelshanskaya MV; Department of Biochemistry and Molecular Biophysics, Columbia University, New York, NY, USA., Nadezhdin KD; Department of Biochemistry and Molecular Biophysics, Columbia University, New York, NY, USA., Yen LY; Department of Biochemistry and Molecular Biophysics, Columbia University, New York, NY, USA.; Cellular and Molecular Physiology and Biophysics Graduate Program, Columbia University Irving Medical Center, New York, NY, USA., Newton TP; Department of Biochemistry and Molecular Biophysics, Columbia University, New York, NY, USA.; Integrated Program in Cellular, Molecular and Biomedical Studies, Columbia University Irving Medical Center, New York, NY, USA., Aktolun M; Department of Chemistry, Carnegie Mellon University, Pittsburgh, PA, USA., Kurnikova MG; Department of Chemistry, Carnegie Mellon University, Pittsburgh, PA, USA., Sobolevsky AI; Department of Biochemistry and Molecular Biophysics, Columbia University, New York, NY, USA. as4005@cumc.columbia.edu.

Publikováno v: Nature [Nature] 2024 Jun; Vol. 630 (8017), pp. 762-768. Date of Electronic Publication: 2024 May 22.

Structural basis of selective TRPM7 inhibition by the anticancer agent CCT128930.

Autor: Nadezhdin KD; Department of Biochemistry and Molecular Biophysics, Columbia University, New York, NY, USA., Correia L; Walther-Straub Institute of Pharmacology and Toxicology, LMU Munich, Munich, Germany., Shalygin A; Comprehensive Pneumology Center, a Member of the German Center for Lung Research (DZL), Munich, Germany., Aktolun M; Department of Chemistry, Carnegie Mellon University, Pittsburgh, PA, USA., Neuberger A; Department of Biochemistry and Molecular Biophysics, Columbia University, New York, NY, USA., Gudermann T; Walther-Straub Institute of Pharmacology and Toxicology, LMU Munich, Munich, Germany; Comprehensive Pneumology Center, a Member of the German Center for Lung Research (DZL), Munich, Germany., Kurnikova MG; Department of Chemistry, Carnegie Mellon University, Pittsburgh, PA, USA., Chubanov V; Walther-Straub Institute of Pharmacology and Toxicology, LMU Munich, Munich, Germany. Electronic address: vladimir.chubanov@lrz.uni-muenchen.de., Sobolevsky AI; Department of Biochemistry and Molecular Biophysics, Columbia University, New York, NY, USA. Electronic address: as4005@cumc.columbia.edu.

Publikováno v: Cell reports [Cell Rep] 2024 Apr 23; Vol. 43 (4), pp. 114108. Date of Electronic Publication: 2024 Apr 12.

Structure of human TRPV4 in complex with GTPase RhoA.

Autor: Nadezhdin KD; Department of Biochemistry and Molecular Biophysics, Columbia University, New York, NY, 10032, USA., Talyzina IA; Department of Biochemistry and Molecular Biophysics, Columbia University, New York, NY, 10032, USA.; Integrated Program in Cellular, Molecular and Biomedical Studies, Columbia University, New York, NY, 10032, USA., Parthasarathy A; Department of Medicine, Cardiovascular Center, Medical College of Wisconsin, Milwaukee, WI, 53226, USA., Neuberger A; Department of Biochemistry and Molecular Biophysics, Columbia University, New York, NY, 10032, USA., Zhang DX; Department of Medicine, Cardiovascular Center, Medical College of Wisconsin, Milwaukee, WI, 53226, USA.; Department of Pharmacology and Toxicology, Medical College of Wisconsin, Milwaukee, WI, 53226, USA., Sobolevsky AI; Department of Biochemistry and Molecular Biophysics, Columbia University, New York, NY, 10032, USA. as4005@cumc.columbia.edu.

Publikováno v: Nature communications [Nat Commun] 2023 Jun 23; Vol. 14 (1), pp. 3733. Date of Electronic Publication: 2023 Jun 23.