Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Nadezhda V. Povysheva"'
Autor:
Nadezhda V. Povysheva, Jon W. Johnson
Publikováno v:
Neurobiology of Disease, Vol 96, Iss , Pp 75-83 (2016)
Memantine is one of the few drugs currently approved for treatment of Alzheimer's disease (AD). The clinical effects of memantine are thought to be associated with inhibition of NMDA receptors (NMDARs). Surprisingly, other open-channel NMDAR blockers
Externí odkaz:
https://doaj.org/article/edad244e09a4466bbb722654f71c2c43
Publikováno v:
PLoS ONE, Vol 8, Iss 8, p e70553 (2013)
In the prefrontal cortex, parvalbumin-positive inhibitory neurons play a prominent role in the neural circuitry that subserves working memory, and alterations in these neurons contribute to the pathophysiology of schizophrenia. Two morphologically di
Externí odkaz:
https://doaj.org/article/73b0b4950ee74b30908040599d756061
Publikováno v:
The Journal of Neuroscience. 37:9686-9704
Memantine and ketamine are clinically useful NMDA receptor (NMDAR) open channel blockers that inhibit NMDARs with similar potency and kinetics, but display vastly different clinical profiles. This discrepancy has been hypothesized to result from inhi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ef5bb95253f152cbc1bc6dd57a172ad2
https://doi.org/10.1523/jneurosci.1173-17.2017
https://doi.org/10.1523/jneurosci.1173-17.2017
Autor:
Nadezhda V. Povysheva, David A. Lewis, Cameron Olezene, Guillermo Gonzalez-Burgos, Diana C. Rotaru, Aleksey V. Zaitsev, Takeaki Miyamae
Publikováno v:
Journal of Neurophysiology, 113(6), 1850-1861. American Physiological Society
In rodent cortex GABAA receptor (GABAAR)-mediated synapses are a significant source of input onto GABA neurons, and the properties of these inputs vary among GABA neuron subtypes that differ in molecular markers and firing patterns. Some features of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::12cd55fa7023841f9f6d1f8aab6601c5
https://doi.org/10.1152/jn.00799.2014
https://doi.org/10.1152/jn.00799.2014
Publikováno v:
Journal of Neurophysiology. 108:595-609
The activity of supragranular pyramidal neurons in the dorsolateral prefrontal cortex (DLPFC) neurons is hypothesized to be a key contributor to the cellular basis of working memory in primates. Therefore, the intrinsic membrane properties, a crucial
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1396ac8580b9fd340d45fea48de9e9a5
https://doi.org/10.1152/jn.00859.2011
https://doi.org/10.1152/jn.00859.2011
Autor:
Aleksey V. Zaitsev, German Barrionuevo, S. Kröner, Nadezhda V. Povysheva, Satish Iyengar, Guillermo Gonzalez-Burgos, Leonid S. Krimer, Gabriela Czanner, David A. Lewis
Publikováno v:
Journal of Neurophysiology. 94:3009-3022
In primates, little is known about intrinsic electrophysiological properties of neocortical neurons and their morphological correlates. To classify inhibitory cells (interneurons) in layers 2–3 of monkey dorsolateral prefrontal cortex we used whole
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3a01534ff22e534364f15e07a03c33d2
https://doi.org/10.1152/jn.00156.2005
https://doi.org/10.1152/jn.00156.2005
Publikováno v:
Current opinion in pharmacology. 20
The clinical benefits of the glutamate receptor antagonists memantine and ketamine have helped sustain optimism that glutamate receptors represent viable targets for development of therapeutic drugs. Both memantine and ketamine antagonize N-methyl-D-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b10fbad4f3694438edf586f2985ee855
https://pubmed.ncbi.nlm.nih.gov/25462293
https://pubmed.ncbi.nlm.nih.gov/25462293
Publikováno v:
PLoS ONE
PLoS ONE, Vol 8, Iss 8, p e70553 (2013)
PLoS ONE, Vol 8, Iss 8, p e70553 (2013)
In the prefrontal cortex, parvalbumin-positive inhibitory neurons play a prominent role in the neural circuitry that subserves working memory, and alterations in these neurons contribute to the pathophysiology of schizophrenia. Two morphologically di
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::df799ac07f4e88bcad1804317bd2b8fc
https://pubmed.ncbi.nlm.nih.gov/23950961
https://pubmed.ncbi.nlm.nih.gov/23950961
Autor:
Nadezhda V. Povysheva, Jon W. Johnson
Tonically activated neuronal currents mediated by N-methyl-d-aspartate receptors (NMDARs) have been hypothesized to contribute to normal neuronal function as well as to neuronal pathology resulting from excessive activation of glutamate receptors (e.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5629de38c9116bdd80dc30b214d7baa6
https://europepmc.org/articles/PMC3331604/
https://europepmc.org/articles/PMC3331604/
Autor:
Diana C. Rotaru, David A. Lewis, Aleksey V. Zaitsev, Guillermo Gonzalez-Burgos, Nadezhda V. Povysheva
Publikováno v:
Journal of neurophysiology. 101(2)
The plasma membrane GABA transporter GAT1 is thought to mediate uptake of synaptically released GABA. In the primate dorsolateral prefrontal cortex (DLPFC), GAT1 expression changes significantly during development and in schizophrenia. The consequenc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::81b55aefc24b83f54ed77fe4cc849058
https://pubmed.ncbi.nlm.nih.gov/19073797
https://pubmed.ncbi.nlm.nih.gov/19073797