Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Nadezhda L. Mironova"'
Autor:
Maxim S. Kupryushkin, Anton V. Filatov, Nadezhda L. Mironova, Olga A. Patutina, Ivan V. Chernikov, Elena L. Chernolovskaya, Marina A. Zenkova, Dmitrii V. Pyshnyi, Dmitry A. Stetsenko, Sidney Altman, Valentin V. Vlassov
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 27, Iss , Pp 211-226 (2022)
Antisense gapmer oligonucleotides containing phosphoryl guanidine (PG) groups, e.g., 1,3-dimethylimidazolidin-2-imine, at three to five internucleotidic positions adjacent to the 3′ and 5′ ends were prepared via the Staudinger chemistry, which is
Externí odkaz:
https://doaj.org/article/c83f7d0cf88a49389f1c3548b177f3e2
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 20, Iss , Pp 50-61 (2020)
Tumor-associated cell-free DNAs (cfDNAs) are found to play some important roles at different stages of tumor progression; they are involved in the transformation of normal cells and contribute to tumor migration and invasion. DNase I is considered a
Externí odkaz:
https://doaj.org/article/c073b435162f49aabf5462aa84315286
Autor:
Oleg V. Markov, Aleksandra V. Sen’kova, Islam S. Mohamed, Elena V. Shmendel, Mikhail A. Maslov, Anastasiya L. Oshchepkova, Evgeniy V. Brenner, Nadezhda L. Mironova, Marina A. Zenkova
Publikováno v:
Pharmaceutics, Vol 14, Iss 11, p 2542 (2022)
Cell-free antitumor vaccines represent a promising approach to immunotherapy of cancer. Here, we compare the antitumor potential of cell-free vaccines based on microvesicles derived from dendritic cells (DCs) with DC- and cationic-liposome-based vacc
Externí odkaz:
https://doaj.org/article/eb3ad4ee0c254b07bea709de01437fb6
Autor:
Islam Saber Ead Mohamed, Aleksandra V. Sen’kova, Oleg V. Markov, Andrey V. Markov, Innokenty A. Savin, Marina A. Zenkova, Nadezhda L. Mironova
Publikováno v:
Pharmaceutics, Vol 14, Iss 6, p 1173 (2022)
In this investigation, we extensively studied the mechanism of antitumor activity of bovine pancreatic RNase A. Using confocal microscopy, we show that after RNase A penetration into HeLa and B16 cells, a part of the enzyme remains unbound with the r
Externí odkaz:
https://doaj.org/article/3f3cae006e2e4858bf3bff7765acd96c
Autor:
Olga A. Patutina, Svetlana K. Miroshnichenko, Nadezhda L. Mironova, Aleksandra V. Sen’kova, Elena V. Bichenkova, David J. Clarke, Valentin V. Vlassov, Marina A. Zenkova
Publikováno v:
Frontiers in Pharmacology, Vol 10 (2019)
Control of the expression of oncogenic small non-coding RNAs, notably microRNAs (miRNAs), is an attractive therapeutic approach. We report a design platform for catalytic knockdown of miRNA targets with artificial, sequence-specific ribonucleases. mi
Externí odkaz:
https://doaj.org/article/f4b56814e4af47f7b059a8be3d18d8f9
Autor:
Islam Saber Ead Mohamed, Aleksandra V. Sen’kova, Alsu I. Nadyrova, Innokenty A. Savin, Andrey V. Markov, Vladimir A. Mitkevich, Aleksander A. Makarov, Olga N. Ilinskaya, Nadezhda L. Mironova, Marina A. Zenkova
Publikováno v:
Biomolecules, Vol 10, Iss 11, p 1509 (2020)
The important role of miRNA in cell proliferation and differentiation has raised interest in exogenous ribonucleases (RNases) as tools to control tumour-associated intracellular and extracellular miRNAs. In this work, we evaluated the effects of the
Externí odkaz:
https://doaj.org/article/5447cbac80b4402c8796f22b3b9411ba
Autor:
Ludmila A Alekseeva, Nadezhda L Mironova, Evgenyi V Brenner, Alexander M Kurilshikov, Olga A Patutina, Marina A Zenkova
Publikováno v:
PLoS ONE, Vol 12, Iss 2, p e0171988 (2017)
Taking into account recently obtained data indicating the participation of circulating extracellular DNA (exDNA) in tumorigenesis, enzymes with deoxyribonucleic activity have again been considered as potential antitumour and antimetastatic drugs. Pre
Externí odkaz:
https://doaj.org/article/2dcbbebd1fe042e0af3255dbcedff788
Publikováno v:
PLoS ONE, Vol 10, Iss 9, p e0136911 (2015)
Recent data on the application of dendritic cells (DCs) as anti-tumor vaccines has shown their great potential in therapy and prophylaxis of cancer. Here we report on a comparison of two treatment schemes with DCs that display the models of prophylac
Externí odkaz:
https://doaj.org/article/1af6aeee48d24518bf560c0d46f4009d