Zobrazeno 1 - 10
of 26
pro vyhledávání: '"Nadezda A. Stepicheva"'
Autor:
Haitao Liu, Nadezda A. Stepicheva, Sayan Ghosh, Peng Shang, Olivia Chowdhury, Rachel A. Daley, Meysam Yazdankhah, Urvi Gupta, Stacey L. Hose, Mallika Valapala, Christopher Scott Fitting, Anastasia Strizhakova, Yang Shan, Derrick Feenstra, José-Alain Sahel, Ashwath Jayagopal, James T. Handa, J. Samuel Zigler, Patrice E. Fort, Akrit Sodhi, Debasish Sinha
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-19 (2022)
Retinal pigment epithelium (RPE) plays an important role in diabetic retinopathy (DR) progression. Here, the authors show AKT1 and AKT2 are reciprocally regulated in the RPE of DR donor tissue and diabetic mice, reducing Akt2 in RPE causing a compens
Externí odkaz:
https://doaj.org/article/b6a04d515080449b8de555a71e4835ba
Autor:
Haitao Liu, Sayan Ghosh, Tanuja Vaidya, Sridhar Bammidi, Chao Huang, Peng Shang, Archana Padmanabhan Nair, Olivia Chowdhury, Nadezda A. Stepicheva, Anastasia Strizhakova, Stacey Hose, Nikolaos Mitrousis, Santosh Gopikrishna Gadde, Thirumalesh MB, Pamela Strassburger, Gabriella Widmer, Eleonora M. Lad, Patrice E. Fort, José-Alain Sahel, J. Samuel Zigler Jr., Swaminathan Sethu, Peter D. Westenskow, Alan D. Proia, Akrit Sodhi, Arkasubhra Ghosh, Derrick Feenstra, Debasish Sinha
Publikováno v:
JCI Insight, Vol 8, Iss 12 (2023)
Diabetic retinopathy (DR) is a leading cause of blindness in working-age adults and remains an important public health issue worldwide. Here we demonstrate that the expression of stimulator of interferon genes (STING) is increased in patients with DR
Externí odkaz:
https://doaj.org/article/b18fbfa1ae7541e5a0a6f27bd00d5aed
Autor:
Urvi Gupta, Sayan Ghosh, Callen T. Wallace, Peng Shang, Ying Xin, Archana Padmanabhan Nair, Meysam Yazdankhah, Anastasia Strizhakova, Mark A. Ross, Haitao Liu, Stacey Hose, Nadezda A. Stepicheva, Olivia Chowdhury, Mihir Nemani, Vishnu Maddipatla, Rhonda Grebe, Manjula Das, Kira L. Lathrop, José-Alain Sahel, J. Samuel Zigler, Jiang Qian, Arkasubhra Ghosh, Yuri Sergeev, James T. Handa, Claudette M. St. Croix, Debasish Sinha
Publikováno v:
Autophagy
In dry age-related macular degeneration (AMD), LCN2 (lipocalin 2) is upregulated. Whereas LCN2 has been implicated in AMD pathogenesis, the mechanism remains unknown. Here, we report that in retinal pigmented epithelial (RPE) cells, LCN2 regulates ma
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::940f9b4bb61a237b71a4c999dfaec1c6
https://doi.org/10.1080/15548627.2022.2062887
https://doi.org/10.1080/15548627.2022.2062887
Publikováno v:
Dev Biol
microRNAs (miRNAs) play a critical role in a variety of biological processes, including embryogenesis and the physiological functions of cells. Evolutionarily conserved microRNA-31 (miR-31) has been found to be involved in cancer, bone formation, and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::75de2bc4c56147013a8612fb2723992c
https://doi.org/10.1016/j.ydbio.2021.01.008
https://doi.org/10.1016/j.ydbio.2021.01.008
Autor:
Mara Sullivan, Joseph Weiss, Paul R. Kinchington, Nadezda A. Stepicheva, Peng Shang, Christopher Scott Fitting, José-Alain Sahel, Michael J. Calderon, Shenghe Tian, James T. Handa, Sayan Ghosh, Donald J. Zack, Haitao Liu, Xitiz Chamling, Meysam Yazdankhah, J. Samuel Zigler, Ashwath Jayagopal, Debasish Sinha, Stacey Hose
Publikováno v:
Autophagy
Retinal ganglion cell axons are heavily myelinated (98%) and myelin damage in the optic nerve (ON) severely affects vision. Understanding the molecular mechanism of oligodendrocyte progenitor cell (OPC) differentiation into mature oligodendrocytes wi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::778ec074da17557e71441b07700e68c0
https://doi.org/10.1080/15548627.2020.1871204
https://doi.org/10.1080/15548627.2020.1871204
Autor:
Sayan Ghosh, Peng Shang, Mallika Valapala, Stacey Hose, Debasish Sinha, Haitao Liu, Joseph Weiss, J. Samuel Zigler, Simon C. Watkins, Nadezda A. Stepicheva, Meysam Yazdankhah, Alan M. Watson
Publikováno v:
Cellular and Molecular Life Sciences
Lipocalins are a family of secreted adipokines which play important roles in various biological processes. Lipocalin-2 (LCN-2) has been shown to be involved in acute and chronic inflammation. This particular protein is critical in the pathogenesis of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::93d6efc159fab3aa466a58dad98364bf
https://doi.org/10.1007/s00018-019-03423-8
https://doi.org/10.1007/s00018-019-03423-8
Autor:
Olivia Chowdhury, Sayan Ghosh, Ankur Das, Haitao Liu, Peng Shang, Nadezda A. Stepicheva, Stacey Hose, Debasish Sinha, Sreya Chattopadhyay
Publikováno v:
Cellular Signalling. 101:110521
The unending lifestyle stressors along with genetic predisposition, environmental factors and infections have pushed the immune system into a state of constant activity, leading to unresolved inflammation and increased vulnerability to chronic diseas
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a048b7328a817b29d7932cf7be6519f9
https://doi.org/10.1016/j.cellsig.2022.110521
https://doi.org/10.1016/j.cellsig.2022.110521
Autor:
Stacey Hose, Haitao Liu, Debasish Sinha, Donna B. Stolz, Ming Sun, Peng Shang, Nadezda A. Stepicheva, Olivia Chowdhury, Meysam Yazdankhah, Anastasia Strizhakova, Sayan Ghosh, Jonathan Franks, J. Samuel Zigler
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 11979, p 11979 (2021)
International Journal of Molecular Sciences
Volume 22
Issue 21
International Journal of Molecular Sciences
Volume 22
Issue 21
Degeneration of retinal pigment epithelium (RPE) is one of the most critical phenotypic changes of age-related macular degeneration (AMD), the leading cause of vision loss in the elderly. While cultured polarized RPE cells with original properties ar
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9767aa77fc1999f0a69cbb6f97f13f16
https://www.mdpi.com/1422-0067/22/21/11979
https://www.mdpi.com/1422-0067/22/21/11979
Autor:
Haitao Liu, Nadezda A. Stepicheva, Sayan Ghosh, Peng Shang, Olivia Chowdhury, Rachel A. Daley, Meysam Yazdankhah, Urvi Gupta, Stacey L. Hose, Mallika Valapala, Christopher Scott Fitting, Anastasia Strizhakova, Yang Shan, Derrick Feenstra, José-Alain Sahel, Ashwath Jayagopal, James T. Handa, J. Samuel Zigler, Patrice E. Fort, Akrit Sodhi, Debasish Sinha
Publikováno v:
Nature communications. 13(1)
The retinal pigment epithelium (RPE) plays an important role in the development of diabetic retinopathy (DR), a leading cause of blindness worldwide. Here we set out to explore the role of Akt2 signaling—integral to both RPE homeostasis and glucose
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f630ca542560d30249d8bcd2e7a06f46
https://pubmed.ncbi.nlm.nih.gov/36229454
https://pubmed.ncbi.nlm.nih.gov/36229454
Autor:
Peng Shang, Kenneth Teel, Stacey Hose, Debasish Sinha, Christopher Scott Fitting, Joseph Weiss, Ashwath Jayagopal, Jiang Qian, Imran Ahmed Bhutto, Yuri V. Sergeev, Sayan Ghosh, José-Alain Sahel, James T. Handa, Meysam Yazdankhah, Haitao Liu, Raju V. S. Rajala, Simon C. Watkins, Nadezda A. Stepicheva, J. Samuel Zigler, Austin McCauley, Rhonda Grebe, Anastasia Strizhakova, Gerard A. Lutty
Publikováno v:
Communications Biology
Communications Biology, Nature Publishing Group, 2021, 4, pp.850. ⟨10.1038/s42003-021-02386-6⟩
Communications Biology, Vol 4, Iss 1, Pp 1-14 (2021)
Communications Biology, Nature Publishing Group, 2021, 4, pp.850. ⟨10.1038/s42003-021-02386-6⟩
Communications Biology, Vol 4, Iss 1, Pp 1-14 (2021)
The retinal pigmented epithelium (RPE) is a monolayer of multifunctional cells located at the back of the eye. High membrane turnover and polarization, including formation of actin-based apical microvilli, are essential for RPE function and retinal h
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3e26493b6199259b12a743ef564947ed
https://hal.sorbonne-universite.fr/hal-03283972/document
https://hal.sorbonne-universite.fr/hal-03283972/document
