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Signatures of TOP1 transcription-associated mutagenesis in cancer and germline

Autor: Reijns M. A. M., Parry D. A., Williams T. C., Nadeu F., Hindshaw R. L., Rios Szwed D. O., Nicholson M. D., Carroll P., Boyle S., Royo R., Cornish A. J., Xiang H., Ridout K., Schuh A., Caravagna G, Aden K., Palles C., Campo E., Stankovic T., Taylor M. S., Jackson A. P.

Publikováno v: UPCommons. Portal del coneixement obert de la UPC
Universitat Politècnica de Catalunya (UPC)
Reijns, M A M, Parry, D A, Williams, T C, Nadeu, F, Hindshaw, R L, Rios Szwed, D O, Nicholson, M D, Carroll, P, Boyle, S, Royo, R, Cornish, A J, Xiang, H, Ridout, K, Schuh, A, Aden, K, Palles, C, Campo, E & Stankovic, T & Taylor, M S & Jackson, A P 2022, ' Signatures of TOP1 transcription-associated mutagenesis in cancer and germline ', Nature, vol. 602, pp. 623-631 . https://doi.org/10.1038/s41586-022-04403-y

The mutational landscape is shaped by many processes. Genic regions are vulnerable to mutation but are preferentially protected by transcription-coupled repair1. In microorganisms, transcription has been demonstrated to be mutagenic2,3; however, the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4d3e84d7c12d168ffbad3ff8ab79514a
https://hdl.handle.net/2117/363117

IRF4-rearranged Large B-cell lymphoma (LBCL) has a genomic profile distinct to other LBCL in children and young adults

Autor: Ramis-Zaldivar JE, Gonzalez-Farre B, Balagué O, Celis V, Nadeu F, Salmeron-Villalobos J, Andres M, Martin-Guerrero I, Garrido-Pontnou M, Gaafar A, Suñol M, Barcena C, Garcia-Bragado F, Andión M, Azorín D, Astigarraga I, Sagaseta de Ilurdoz M, Sábado C, Gallego S, Verdu-Amorós J, Fernandez-Delgado R, Perez V, Tapia G, Mozos A, Torrent M, Solano-Páez P, Rivas-Delgado A, Dlouhy I, Clot G, Enjuanes A, López-Guillermo A, Galera PK, Oberley MJ, Maguire A, Ramsower C, Rimsza LM, Quintanilla-Martinez L, Jaffe ES, Campo E, Salaverria I

Publikováno v: Blood
r-IIS La Fe. Repositorio Institucional de Producción Científica del Instituto de Investigación Sanitaria La Fe
instname

Pediatric large B-cell lymphomas (LBCL) share morphological and phenotypic features with adult types but have better prognosis. The higher frequency of some subtypes such as LBCL with IRF4 rearrangement (LBCL-IRF4) in children, suggests that some age

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=RECOLECTA___::60eaea640f9fcc2b70ee686907e08241
https://fundanet.iislafe.san.gva.es/publicaciones/ProdCientif/PublicacionFrw.aspx?id=11643

FIVE‐YEAR UPDATE OF THE FIRST‐LINE IMCL‐2015 GELTAMO STUDY. PROLONGED MOLECULAR AND CLINICAL RESPONSES WERE OBSERVED AFTER MRD‐DRIVEN IBRUTINIB DISCONTINUATION.

Autor: Giné, E., Medina‐Herrera, A., Cruz, F. de la, Ubieto, A. Jiménez, Jiménez, J. López, García‐ Sancho, A. Martín, Terol, M J., Barca, E. González, Casanova, M., Fuente, A. de la, Niebla, A. Marín, Muntañola, A., López, T. J. González, Aymerich, M., Setoain, X., Cortés‐Romera, M., Rotger, A., Rodríguez, S., López, C., Nadeu, F.

Publikováno v: Hematological Oncology; Jun2023 Supplement 1, Vol. 41, p148-150, 3p