Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Nader Ezzeddine"'
Publikováno v:
PLoS ONE, Vol 3, Iss 1, p e1466 (2008)
Evidence for an RNA gain-of-function toxicity has now been provided for an increasing number of human pathologies. Myotonic dystrophies (DM) belong to a class of RNA-dominant diseases that result from RNA repeat expansion toxicity. Specifically, DM o
Externí odkaz:
https://doaj.org/article/3f3d993186ed493ab6b27f0f00459dc5
Autor:
Funda Meric-Bernstam, Yuan Qi, Wanding Zhou, Amber Johnson, Xiaofeng Zheng, Rajyalakshmi Luthra, Hao Zhao, Lin ya Tang, Tenghui Chen, Kenna Mills Shaw, Zechen Chong, Ravi Vinod, Carol J. Farhangfar, Gordon B. Mills, Michael A. Davies, Qingxiu Zhang, Stacy L. Moulder, Scott Kopetz, Kenneth Aldape, Ken Chen, Nader Ezzeddine, John de Groot, Mark J. Routbort, Yong Mao, John Mendelsohn, Agda Karina Eterovic
Publikováno v:
Clinical Chemistry. 61:544-553
BACKGROUND Further advances of targeted cancer therapy require comprehensive in-depth profiling of somatic mutations that are present in subpopulations of tumor cells in a clinical tumor sample. However, it is unclear to what extent such intratumor h
The mammalian TOB1 and TOB2 proteins have emerged as key players in repressing cell proliferation. Accumulating evidence indicates that TOBs regulate mRNA deadenylation. A recruitment model was proposed in which TOBs promote deadenylation by recruiti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2c33d4ae5560f2d33448c86aa1fa717e
https://europepmc.org/articles/PMC5492180/
https://europepmc.org/articles/PMC5492180/
Autor:
Heather Meador, Wafik Zaky, Najat C. Daw, Lin-ya Tang, Ping Song, Jonathan Gill, Agda Karina Eterovic, Shulin Li, Nader Ezzeddine, Michelle A.T. Hildebrandt, Mohammad M. Mohammad, Soumen Khatua
Publikováno v:
Neuro-Oncology. 21:ii88-ii88
Midline K27M gliomas are the most challenging type of gliomas in pediatric patients with very poor outcome (median survival, 9–12 months). Because their anatomic location, brainstem and thalamic gliomas are inoperable and hence no tissue is availab
Autor:
William F. Marzluff, Jiandong Chen, Todd R. Albrecht, Eric J. Wagner, Bernhard Waltenspiel, Nader Ezzeddine, William D. Warren
Publikováno v:
RNA. 18:2148-2156
Formation of the 3′ end of RNA polymerase II–transcribed snRNAs requires a poorly understood group of proteins called the Integrator complex. Here we used a fluorescence-based read-through reporter that expresses GFP in response to snRNA misproce
Publikováno v:
Molecular and Cellular Biology. 32:1089-1098
The mammalian TOB1 and TOB2 proteins have emerged as key players in repressing cell proliferation. Accumulating evidence indicates that TOBs regulate mRNA deadenylation. A recruitment model was proposed in which TOBs promote deadenylation by recruiti
Autor:
William D. Warren, Todd R. Albrecht, Ming Zhuo, Eric J. Wagner, William F. Marzluff, Brandon D. Burch, Nader Ezzeddine, Bernhard Waltenspiel, Jiandong Chen
Publikováno v:
Molecular and Cellular Biology. 31:328-341
Proper gene expression relies on a class of ubiquitously expressed, uridine-rich small nuclear RNAs (snRNAs) transcribed by RNA polymerase II (RNAPII). Vertebrate snRNAs are transcribed from a unique promoter, which is required for proper 3′-end fo
Publikováno v:
The Journal of Cell Biology
Deadenylation is the major step triggering mammalian mRNA decay. One consequence of deadenylation is the formation of nontranslatable messenger RNA (mRNA) protein complexes (messenger ribonucleoproteins [mRNPs]). Nontranslatable mRNPs may accumulate
Autor:
Dinghai Zheng, Nader Ezzeddine, Chyi-Ying A. Chen, Wenmiao Zhu, Yukiko M. Yamashita, Ann-Bin Shyu, Tsung Cheng Chang, Akio Yamashita, Zhenping Zhong
Publikováno v:
Molecular and Cellular Biology. 27:7791-7801
In mammalian cells, mRNA decay begins with deadenylation, which involves two consecutive phases mediated by the PAN2-PAN3 and the CCR4-CAF1 complexes, respectively. The regulation of the critical deadenylation step and its relationship with RNA-proce
Publikováno v:
The Journal of Cell Biology
We report that the Drosophila mind bomb2 (mib2) gene is a novel regulator of muscle development. Unlike its paralogue, mib1, zygotic expression of mib2 is restricted to somatic and visceral muscle progenitors, and their respective differentiated musc