Zobrazeno 1 - 10
of 22
pro vyhledávání: '"Nader El-Sayes"'
Autor:
Nader El-Sayes, Scott Walsh, Alyssa Vito, Amir Reihani, Kjetil Ask, Yonghong Wan, Karen Mossman
Publikováno v:
Molecular Therapy: Oncolytics, Vol 25, Iss , Pp 16-30 (2022)
Oncolytic virotherapies have shown excellent promise in a variety of cancers by promoting antitumor immunity. However, the effects of oncolytic virus-mediated type I interferon (IFN-I) production on antitumor immunity remain unclear. Recent reports h
Externí odkaz:
https://doaj.org/article/f50ae52953884321ac667952ec889d27
Autor:
Alyssa Vito, Omar Salem, Nader El-Sayes, Ian P. MacFawn, Ana L. Portillo, Katy Milne, Danielle Harrington, Ali A. Ashkar, Yonghong Wan, Samuel T. Workenhe, Brad H. Nelson, Tullia C. Bruno, Karen L. Mossman
Publikováno v:
Communications Biology, Vol 4, Iss 1, Pp 1-19 (2021)
Vito et al. investigated the effects of combination therapy in a TNBC tumor model and reported increased tumor-infiltrating lymphocytes that contributed to an improved response to immune checkpoint blockade. By depletion of circulating B cells prior
Externí odkaz:
https://doaj.org/article/05222c9ff4534f789861496bd23f86ca
Autor:
Dean A. Fergusson, Neil L. Wesch, Garvin J. Leung, Jenna L. MacNeil, Isidora Conic, Justin Presseau, Kelly D. Cobey, Jean-Simon Diallo, Rebecca Auer, Jonathan Kimmelman, Natasha Kekre, Nader El-Sayes, Ramya Krishnan, Brian A. Keller, Carolina Ilkow, Manoj M. Lalu
Publikováno v:
Molecular Therapy: Oncolytics, Vol 14, Iss , Pp 179-187 (2019)
Irreproducibility of preclinical findings could be a significant barrier to the “bench-to-bedside” development of oncolytic viruses (OVs). A contributing factor is the incomplete and non-transparent reporting of study methodology and design. Usin
Externí odkaz:
https://doaj.org/article/9bde4d6581414697883c3a664edf2274
Autor:
Arinjay Banerjee, Nader El-Sayes, Patrick Budylowski, Rajesh Abraham Jacob, Daniel Richard, Hassaan Maan, Jennifer A. Aguiar, Wael L. Demian, Kaushal Baid, Michael R. D'Agostino, Jann Catherine Ang, Tetyana Murdza, Benjamin J.-M. Tremblay, Sam Afkhami, Mehran Karimzadeh, Aaron T. Irving, Lily Yip, Mario Ostrowski, Jeremy A. Hirota, Robert Kozak, Terence D. Capellini, Matthew S. Miller, Bo Wang, Samira Mubareka, Allison J. McGeer, Andrew G. McArthur, Andrew C. Doxey, Karen Mossman
Publikováno v:
iScience, Vol 24, Iss 5, Pp 102477- (2021)
Summary: Type I interferons (IFNs) are our first line of defense against virus infection. Recent studies have suggested the ability of SARS-CoV-2 proteins to inhibit IFN responses. Emerging data also suggest that timing and extent of IFN production i
Externí odkaz:
https://doaj.org/article/7903286efe6640018b5c5ad804e712c6
Autor:
Nader El-Sayes, Alyssa Vito, Omar Salem, Samuel Tekeste Workenhe, Yonghong Wan, Karen Mossman
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 3, p 1754 (2022)
Immune checkpoint therapy has shown great promise in the treatment of cancers with a high mutational burden, such as mismatch repair-deficient colorectal carcinoma (dMMR CRC). However, many patients fail to respond to immune checkpoint therapy. Using
Externí odkaz:
https://doaj.org/article/90a8219725f847699ba94aa0b0299757
Autor:
Alyssa Vito, Stephanie Rathmann, Natalie Mercanti, Nader El-Sayes, Karen Mossman, John Valliant
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 9, p 4843 (2021)
Triple negative breast cancer (TNBC) is an aggressive subtype of the disease with poor clinical outcomes and limited therapeutic options. Immune checkpoint blockade (CP) has surged to the forefront of cancer therapies with widespread clinical success
Externí odkaz:
https://doaj.org/article/aa095d62739b4400866a09adbb7c7150
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 9, p 4893 (2021)
Programmed cell death protein 1 (PD-1), a receptor on T cells, and its ligand, PD-L1, have been a topic of much interest in cancer research. Both tumour and virus-infected cells can upregulate PD-L1 to suppress cytotoxic T-cell killing. Research on t
Externí odkaz:
https://doaj.org/article/a448dfcd669641f7aa974f1073db370a
Publikováno v:
Cells, Vol 9, Iss 4, p 992 (2020)
The tumor microenvironment is a complex ecosystem comprised of many different cell types, abnormal vasculature and immunosuppressive cytokines. The irregular growth kinetics with which tumors grow leads to increased oxygen consumption and, in turn, h
Externí odkaz:
https://doaj.org/article/1a0e678d0f7e4c158ab260377500f844
Autor:
Nader El-Sayes, Alyssa Vito, Omar Salem, Samuel Tekeste Workenhe, Yonghong Wan, Karen Mossman
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 1754, p 1754 (2022)
International Journal of Molecular Sciences; Volume 23; Issue 3; Pages: 1754
International Journal of Molecular Sciences; Volume 23; Issue 3; Pages: 1754
Immune checkpoint therapy has shown great promise in the treatment of cancers with a high mutational burden, such as mismatch repair-deficient colorectal carcinoma (dMMR CRC). However, many patients fail to respond to immune checkpoint therapy. Using
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0885d7454c7f83f7a630bb080e938174
https://pubmed.ncbi.nlm.nih.gov/35163675
https://pubmed.ncbi.nlm.nih.gov/35163675
Publikováno v:
Cancers
Volume 13
Issue 21
Cancers, Vol 13, Iss 5590, p 5590 (2021)
Volume 13
Issue 21
Cancers, Vol 13, Iss 5590, p 5590 (2021)
Simple Summary We have previously reported that a combination of clinical chemotherapies and oncolytic HSV-1 works to sensitize tumors to respond to immune checkpoint blockade. We further showed that this therapeutic platform worked via the upregulat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::282bc705521bf1f0a10d57622ae64210
http://europepmc.org/articles/PMC8582648
http://europepmc.org/articles/PMC8582648