Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Nadege Gruel"'
Autor:
Birgit Geoerger, Aurélien Marabelle, Gaelle Pierron, Nadege Gruel, Arnaud Gauthier, Olivier Delattre, Gudrun Schleiermacher, Ana Costa, Cécile Thirant, Amira Kramdi, Cécile Pierre-Eugène, Caroline Louis-Brennetot, Orphée Blanchard, Didier Surdez, Eve Lapouble, Deborah Sitbon, Hervé Brisse, Paul Fréneaux, Mylène Bohec, Virginie Raynal, Sylvain Baulande, Renaud Leclere, Gabriel Champenois, Andre Nicolas, Didier Meseure, Angela Bellini, Fatima Mechta-Grigoriou, Laurie Menger, Isabelle Janoueix-Lerosey
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 10, Iss 8 (2022)
Background High-risk neuroblastoma is a pediatric cancer with still a dismal prognosis, despite multimodal and intensive therapies. Tumor microenvironment represents a key component of the tumor ecosystem the complexity of which has to be accurately
Externí odkaz:
https://doaj.org/article/94bfccd475c140a08e383b0eb1c1e8c1
Autor:
Diane Damotte, Nadine BenHamouda, Ludger Johannes, Estelle Dransart, Eric Tartour, Emmanuel Donnadieu, Léa Paolini, Fathia Mami-Chouaib, Charlotte Blanc, Sebastian Kobold, Soumaya Karaki, Thi Tran, Isabelle Galy-Fauroux, Alice Mougel, Marie Anson, Corinne Tanchot, Nadege Gruel, Laure Gibault, Francoise Lepimpec-Barhes, Elizabeth Fabre, Cecile Badoual, Rachel Golub
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 9, Iss 3 (2021)
Background Resident memory T lymphocytes (TRM) are located in tissues and play an important role in immunosurveillance against tumors. The presence of TRM prior to treatment or their induction is associated to the response to anti-Programmed cell dea
Externí odkaz:
https://doaj.org/article/7396a1c31d234ef2b59347b1a9805e52
Autor:
Marie-Ming Aynaud, Olivier Mirabeau, Nadege Gruel, Sandrine Grossetête, Valentina Boeva, Simon Durand, Didier Surdez, Olivier Saulnier, Sakina Zaïdi, Svetlana Gribkova, Aziz Fouché, Ulykbek Kairov, Virginie Raynal, Franck Tirode, Thomas G.P. Grünewald, Mylene Bohec, Sylvain Baulande, Isabelle Janoueix-Lerosey, Jean-Philippe Vert, Emmanuel Barillot, Olivier Delattre, Andrei Zinovyev
Publikováno v:
Cell Reports, Vol 30, Iss 6, Pp 1767-1779.e6 (2020)
Summary: EWSR1-FLI1, the chimeric oncogene specific for Ewing sarcoma (EwS), induces a cascade of signaling events leading to cell transformation. However, it remains elusive how genetically homogeneous EwS cells can drive the heterogeneity of transc
Externí odkaz:
https://doaj.org/article/17c804ad436946fd839b98dcb2674815
Autor:
Gabrielle Manteaux, Alix Amsel, Blanche Riquier-Morcant, Jaime Prieto Romero, Laurie Gayte, Benjamin Fourneaux, Marion Larroque, Nadège Gruel, Chloé Quignot, Gaelle Perot, Solenn Jacq, Madi Y. Cisse, Pascal Pomiès, Coralie Sengenes, Frédéric Chibon, Maud Heuillet, Floriant Bellvert, Sarah Watson, Sebastien Carrere, Nelly Firmin, Romain Riscal, Laetitia K. Linares
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-15 (2024)
Abstract Dedifferentiated and Well-differentiated liposarcoma are characterized by a systematic amplification of the Murine Double Minute 2 (MDM2) oncogene. We demonstrate that p53-independent metabolic functions of chromatin-bound MDM2 are exacerbat
Externí odkaz:
https://doaj.org/article/b0fec26a6a6443049f7aba6728e01c6f
Autor:
Nadège Gruel, Chloé Quignot, Laëtitia Lesage, Sophie El Zein, Sylvie Bonvalot, Dimitri Tzanis, Khadija Ait Rais, Fabien Quinquis, Bastien Manciot, Julien Vibert, Nadine El Tannir, Ahmed Dahmani, Héloïse Derrien, Didier Decaudin, Ivan Bièche, Laura Courtois, Odette Mariani, Laëtitia K. Linares, Laurie Gayte, Sylvain Baulande, Joshua J. Waterfall, Olivier Delattre, Gaëlle Pierron, Sarah Watson
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-18 (2024)
Abstract Dedifferentiated liposarcoma (DDLPS) is the most frequent high-grade soft tissue sarcoma subtype. It is characterized by a component of undifferentiated tumor cells coexisting with a component of well-differentiated adipocytic tumor cells. B
Externí odkaz:
https://doaj.org/article/9071f50c747241d985e7d638e844b164
Autor:
Nicolas Jacquin, Ronan Flippot, Julien Masliah-Planchon, Guillaume Grisay, Riwan Brillet, Célia Dupain, Maud Kamal, Isabelle Guillou, Nadège Gruel, Nicolas Servant, Pierre Gestraud, Jennifer Wong, Vincent Cockenpot, Andreia Goncalves, Janick Selves, Hélène Blons, Etienne Rouleau, Olivier Delattre, Claire Gervais, Christophe Le Tourneau, Ivan Bièche, Yves Allory, Laurence Albigès, Sarah Watson
Publikováno v:
npj Precision Oncology, Vol 8, Iss 1, Pp 1-6 (2024)
Abstract Metastatic carcinoma of presumed renal origin (rCUP) has recently emerged as a new entity within the heterogeneous entity of Cancers of Unknown Primary (CUP) but their biological features and optimal therapeutic management remain unknown. We
Externí odkaz:
https://doaj.org/article/8884285fa1394307af735d86552e3c29
Autor:
Ana Costa, Cécile Thirant, Amira Kramdi, Cécile Pierre-Eugène, Caroline Louis-Brennetot, Orphée Blanchard, Didier Surdez, Nadege Gruel, Eve Lapouble, Gaëlle Pierron, Deborah Sitbon, Hervé Brisse, Arnaud Gauthier, Paul Fréneaux, Mylène Bohec, Virginie Raynal, Sylvain Baulande, Renaud Leclere, Gabriel Champenois, Andre Nicolas, Didier Meseure, Angela Bellini, Aurelien Marabelle, Birgit Geoerger, Fatima Mechta-Grigoriou, Gudrun Schleiermacher, Laurie Menger, Olivier Delattre, Isabelle Janoueix-Lerosey
Publikováno v:
J Immunother Cancer
BackgroundHigh-risk neuroblastoma is a pediatric cancer with still a dismal prognosis, despite multimodal and intensive therapies. Tumor microenvironment represents a key component of the tumor ecosystem the complexity of which has to be accurately u
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4fd3d915d0e250d84f2debebee1ae34e
Autor:
Nadine Benhamouda, Anissa Besbes, Rebecca Bauer, Nesrine Mabrouk, Gauthier Gadouas, Corinne Desaint, Lucie Chevrier, Maeva Lefebvre, Anne Radenne, Marie Roelens, Béatrice Parfait, Daniela Weiskopf, Alessandro Sette, Nadège Gruel, Marie Courbebaisse, Victor Appay, Stephane Paul, Guy Gorochov, Jacques Ropers, Said Lebbah, Jean-Daniel Lelievre, Ludger Johannes, Jonathan Ulmer, David Lebeaux, Gerard Friedlander, Xavier De Lamballerie, Patrice Ravel, Marie Paule Kieny, Fréderic Batteux, Christine Durier, Odile Launay, Eric Tartour
Publikováno v:
iScience, Vol 27, Iss 8, Pp 110441- (2024)
Summary: Coordinating immune responses – humoral and cellular – is vital for protection against severe Covid-19. Our study evaluates a multicytokine CD4+T cell signature’s predictive for post-vaccinal serological and CD8+T cell responses. A cyt
Externí odkaz:
https://doaj.org/article/bae9b74a735344409d5106899f8ed864
Autor:
Cécile Thirant, Agathe Peltier, Simon Durand, Amira Kramdi, Caroline Louis-Brennetot, Cécile Pierre-Eugène, Margot Gautier, Ana Costa, Amandine Grelier, Sakina Zaïdi, Nadège Gruel, Irène Jimenez, Eve Lapouble, Gaëlle Pierron, Déborah Sitbon, Hervé J. Brisse, Arnaud Gauthier, Paul Fréneaux, Sandrine Grossetête, Laura G. Baudrin, Virginie Raynal, Sylvain Baulande, Angela Bellini, Jaydutt Bhalshankar, Angel M. Carcaboso, Birgit Geoerger, Hermann Rohrer, Didier Surdez, Valentina Boeva, Gudrun Schleiermacher, Olivier Delattre, Isabelle Janoueix-Lerosey
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-18 (2023)
Abstract Noradrenergic and mesenchymal identities have been characterized in neuroblastoma cell lines according to their epigenetic landscapes and core regulatory circuitries. However, their relationship and relative contribution in patient tumors re
Externí odkaz:
https://doaj.org/article/04ed19984e944c97b2d0494d3dadfd31
Autor:
Thi Tran, Jean-Remi Lavillegrand, Cedric Lereverend, Bruno Esposito, Lucille Cartier, Melanie Montabord, Jaouen Tran-Rajau, Marc Diedisheim, Nadège Gruel, Khadija Ouguerram, Lea Paolini, Olivia Lenoir, Emmanuel Pinteaux, Eva Brabencova, Corinne Tanchot, Pauline Urquia, Jacqueline Lehmann-Che, Richard Le Naour, Yacine Merrouche, Christian Stockmann, Ziad Mallat, Alain Tedgui, Hafid Ait-Oufella, Eric Tartour, Stephane Potteaux
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-15 (2022)
Obesity and inflammation have been associated to cancer progression. Here, the authors show that high fat and cholesterol diet, in a non-obese context, promotes tumourigenesis through increasing inflammatory monocytes and myeloid-derived pro-angiogen
Externí odkaz:
https://doaj.org/article/9d1b5cbfa4cd4a4690d9acceffb058b5