Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Nadeera Wickramasinghe"'
Autor:
Evangelia G. Kranias, Anichavezhi Devendran, Kenneth Fish, Roger J. Hajjar, Francesca Stillitano, Nicole Dubois, Nadeera Wickramasinghe, Kevin D. Costa, Rasheed A. Bailey, Maria G. Trivieri, Irene C. Turnbull, Sumanta Kar
Publikováno v:
Circulation Research. 129
Background: Heart failure (HF) is a complex clinical condition associated with substantial morbidity and mortality worldwide. The contractile dysfunction and arrhythmogenesis related to HF has been linked to the remodelling of calcium (Ca ++ ) handli
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d7aa032dc4b9e79970443c4edde3024b
https://doi.org/10.1161/res.129.suppl_1.p482
https://doi.org/10.1161/res.129.suppl_1.p482
Autor:
Mark Tomishima, Nicole Dubois, Leili Sarrafha, Christoph Schaniel, Shuibing Chen, Damelys Calderon, Nadeera Wickramasinghe
While much progress has been made in understanding early cardiac development, the precise mechanisms that specify the different cardiomyocyte subtypes remain poorly understood. Recent data from our lab have shown that transient Foxa2 expression ident
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6bcadad3edcac65e742e1e592eeabfdb
https://doi.org/10.1101/2021.07.18.452860
https://doi.org/10.1101/2021.07.18.452860
Autor:
Deborah L. French, Madhavika N. Serasinghe, Sander M. Houten, Kristin G. Beaumont, Joshua Mayourian, Kevin D. Costa, Priyanka Dhanan-Krishnan, Harry Ischiropoulos, Robert Sebra, David H. Sachs, Denis Torre, Schahram Akbarian, Elizabeth A. LaMarca, David M. Gonzalez, Arne Hansen, Rafael Dariolli, Nicole Dubois, Avi Ma'ayan, Eric A. Sobie, Bhavana Shewale, Thomas Eschenhagen, Nadeera Wickramasinghe, Ravi Iyengar, Serena Raimo, Jerry E. Chipuk, Adam Jacobs
SUMMARYPluripotent stem cell-derived cardiomyocytes (PSC-CMs) provide an unprecedented opportunity to study human heart development and disease. A major caveat however is that they remain functionally and structurally immature in culture, limiting th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cf695ffd2bad314248a0d47edd60496f
https://doi.org/10.1101/2021.07.12.451352
https://doi.org/10.1101/2021.07.12.451352
Autor:
Roger J. Hajjar, Francesca Stillitano, Rasheed A. Bailey, Irene C. Turnbull, Bruce D. Gelb, MariaGiovanna Triveri, Evangelia G. Kranias, Nadeera Wickramasinghe, Kobra Haghigi, Kenneth Fish, Kevin D. Costa, Nicole Dubois, Fadi G. Akar
Publikováno v:
Circulation Research. 127
Background: Defective calcium (Ca++) handling is a hallmark of HF across species. Together with the Sarco/Endoplasmic Reticulum Ca-ATPase (SERCA2a), Phospholamban (PLN) has emerged as a critical regulator of Ca++homeostasis. Worldwide, PLN mutations
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::74190800179daaddac4f4cbf8968e3fd
https://doi.org/10.1161/res.127.suppl_1.530
https://doi.org/10.1161/res.127.suppl_1.530
Autor:
Carolyn E. Dundes, Sean Whalen, Garrett T. Santini, Eric F. Joyce, Ketrin Gjoni, Parisha P. Shah, Ashley Karnay, Nicole Dubois, Katherine S. Pollard, Angela Chen, Kathleen C. Keough, Kyle M. Loh, Rachel E.A. Salomon, Patrick J. Walsh, Son C. Nguyen, Nadeera Wickramasinghe, Rajan Jain
Association of chromatin with lamin proteins at the nuclear periphery has emerged as a potential mechanism to coordinate cell type-specific gene expression and maintain cellular identity via gene silencing. Unlike many histone modifications and chrom
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2ecc42a9b0cee9fcd153e5941f6c87af
https://doi.org/10.1101/2020.07.23.218768
https://doi.org/10.1101/2020.07.23.218768
Autor:
Andrew J. Sharp, Evan S. Bardot, Nadeera Wickramasinghe, Michael Rendl, Bharati Jadhav, Amélie Rezza, Nicole Dubois
During development multiple progenitor populations contribute to the formation of the four-chambered heart and its diverse lineages. However, the underlying mechanisms that result in the specification of these progenitor populations are not yet fully
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::294a8c8f31099b18b91c76a620a7ab0c
https://doi.org/10.1101/2020.02.20.958348
https://doi.org/10.1101/2020.02.20.958348
Autor:
Yishu Ding, Kevin Yang, Qinglin Yang, Teayoun Kim, Nicole Dubois, Gilbert Weidinger, Qinqiang Long, Mohankrishna Dalvoy Vasudevarao, Lan He, Felix B. Engel, Nadeera Wickramasinghe, Ajit Magadum, Harsha V Renikunta
Publikováno v:
Cell Research
Zebrafish can efficiently regenerate their heart through cardiomyocyte proliferation. In contrast, mammalian cardiomyocytes stop proliferating shortly after birth, limiting the regenerative capacity of the postnatal mammalian heart. Therefore, if the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c63be80b41915595b0e495476de47a53
http://europepmc.org/articles/PMC5539351
http://europepmc.org/articles/PMC5539351