Zobrazeno 1 - 10
of 44
pro vyhledávání: '"Nadeene Parker"'
Autor:
Asmaà Fritah, Jennifer H Steel, Nadeene Parker, Evanthia Nikolopoulou, Mark Christian, David Carling, Malcolm G Parker
Publikováno v:
PLoS ONE, Vol 7, Iss 2, p e32520 (2012)
Skeletal muscle constitutes the major site of glucose uptake leading to increased removal of glucose from the circulation in response to insulin. Type 2 diabetes and obesity are often associated with insulin resistance that can be counteracted by exe
Externí odkaz:
https://doaj.org/article/9ca12774946a49b9baa83119d6024bbf
Autor:
Christopher J Lelliott, Gema Medina-Gomez, Natasa Petrovic, Adrienn Kis, Helena M Feldmann, Mikael Bjursell, Nadeene Parker, Keira Curtis, Mark Campbell, Ping Hu, Dongfang Zhang, Sheldon E Litwin, Vlad G Zaha, Kimberly T Fountain, Sihem Boudina, Mercedes Jimenez-Linan, Margaret Blount, Miguel Lopez, Aline Meirhaeghe, Mohammad Bohlooly-Y, Leonard Storlien, Maria Strömstedt, Michael Snaith, Matej Oresic, E Dale Abel, Barbara Cannon, Antonio Vidal-Puig
Publikováno v:
PLoS Biology, Vol 4, Iss 11, p e369 (2006)
The transcriptional coactivator peroxisome proliferator-activated receptor-gamma coactivator-1beta (PGC-1beta) has been implicated in important metabolic processes. A mouse lacking PGC-1beta (PGC1betaKO) was generated and phenotyped using physiologic
Externí odkaz:
https://doaj.org/article/a339d534b4bb4152b54fabbda95e6768
Autor:
Michael R. Duchen, Nancy A. Curtin, Mervyn Singer, Jane E. Carré, Parjam S. Zolfaghari, Nadeene Parker
Publikováno v:
American Journal of Physiology-Endocrinology and Metabolism. 308:E713-E725
Muscle dysfunction is a common feature of severe sepsis and multiorgan failure. Recent evidence implicates bioenergetic dysfunction and oxidative damage as important underlying pathophysiological mechanisms. Increased abundance of uncoupling protein-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a32744b6a70bc73f2aa4b0ddf43b9463
https://doi.org/10.1152/ajpendo.00562.2014
https://doi.org/10.1152/ajpendo.00562.2014
Publikováno v:
Diabetes, Obesity and Metabolism. 12:134-140
Pancreatic β-cells have remarkable bioenergetics in which increased glucose supply upregulates the cytosolic ATP/ADP ratio and increases insulin secretion. This arrangement allows glucose-stimulated insulin secretion (GSIS) to be regulated by the co
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b6192276c8e977c1df045241d153fb03
https://doi.org/10.1111/j.1463-1326.2010.01264.x
https://doi.org/10.1111/j.1463-1326.2010.01264.x
Publikováno v:
Bioscience Reports
The mPTP (mitochondrial permeability transition pore) is a non-specific channel that is formed in the mitochondrial inner membrane in response to several stimuli, including elevated levels of matrix calcium. The pore is proposed to be composed of the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9ceb2f982de22cd4b7289d28d3ce2752
http://europepmc.org/articles/PMC2805926
http://europepmc.org/articles/PMC2805926
Publikováno v:
Biochimica et Biophysica Acta
Glucose intolerance in C57Bl/6 mice has been associated with mutations in the nicotinamide nucleotide transhydrogenase (Nnt) gene. It has been proposed that the absence of NNT from mitochondria leads to increased mitochondrial reactive oxygen species
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::87ccace3ace9edb6bc9fa7f7f2033293
http://europepmc.org/articles/PMC2741566
http://europepmc.org/articles/PMC2741566
Publikováno v:
Biochimica et Biophysica Acta
Uncoupling protein 2 (UCP2) regulates glucose-stimulated insulin secretion in pancreatic beta-cells. UCP2 content, measured by calibrated immunoblot in INS-1E insulinoma cells (a pancreatic beta-cell model) grown in RPMI medium, and INS-1E mitochondr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7b8bf15e0796deb8ebd13c2267a970a2
https://doi.org/10.1016/j.bbabio.2008.07.001
https://doi.org/10.1016/j.bbabio.2008.07.001
Publikováno v:
Biochemical Journal
Mitochondria generate reactive oxygen species, whose downstream lipid peroxidation products, such as 4-hydroxynonenal, induce uncoupling of oxidative phosphorylation by increasing proton leak through mitochondrial inner membrane proteins such as the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c56c53c585fb4858452508f14e9b42c9
https://doi.org/10.1042/bj20080321
https://doi.org/10.1042/bj20080321
Stimulation of mitochondrial proton conductance by hydroxynonenal requires a high membrane potential
Publikováno v:
Bioscience Reports
Mild uncoupling of oxidative phosphorylation, caused by a leak of protons back into the matrix, limits mitochondrial production of ROS (reactive oxygen species). This proton leak can be induced by the lipid peroxidation products of ROS, such as HNE (
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::562080dfbea250be86f3769550e1cec2
http://europepmc.org/articles/PMC2518262
http://europepmc.org/articles/PMC2518262
Autor:
Dominic J. Withers, Benoit Viollet, Kaisa Piipari, Michael L.J. Ashford, David Carling, Craig Beall, Nadeene Parker, Hind Al-Qassab, Mark A. Smith
Publikováno v:
Biochemical Journal
AMPK (AMP-activated protein kinase) signalling plays a key role in whole-body energy homoeostasis, although its precise role in pancreatic beta-cell function remains unclear. In the present study, we therefore investigated whether AMPK plays a critic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d456e9d47ca024276f0a953512745795
https://pubmed.ncbi.nlm.nih.gov/20465544
https://pubmed.ncbi.nlm.nih.gov/20465544