Zobrazeno 1 - 10 of 98 pro vyhledávání: '"Nadeem A. Afzal"'
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Akademický článek
Expression profile of the matricellular protein periostin in paediatric inflammatory bowel disease
Autor: Tracy Coelho, Eva Sonnenberg-Riethmacher, Yifang Gao, Enrico Mossotto, Alisher Khojanazarov, Annie Griffin, Saida Mukanova, Aiymkul Ashimkhanova, Rachel Haggarty, Anton Borissenko, James J. Ashton, Imogen S. Stafford, Akshay Batra, Nadeem A. Afzal, Michael P. Stanton, Bhumita Vadgama, Kapura Adrisova, Robert M. Beattie, Anthony P. Williams, Sarah Ennis, Dieter Riethmacher
Publikováno v: Scientific Reports, Vol 11, Iss 1, Pp 1-13 (2021)
Abstract The precise role of periostin, an extra-cellular matrix protein, in inflammatory bowel disease (IBD) is unclear. Here, we investigated periostin in paediatric IBD including its relationship with disease activity, clinical outcomes, genomic v
Externí odkaz: https://doaj.org/article/3f97eee59cb1479faae9c5a30eaf5c4d
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2
Prediction of Crohn’s Disease Stricturing Phenotype Using a NOD2-derived Genomic Biomarker
Autor: James J Ashton, Guo Cheng, Imogen S Stafford, Melina Kellermann, Eleanor G Seaby, J R Fraser Cummings, Tracy A F Coelho, Akshay Batra, Nadeem A Afzal, R Mark Beattie, Sarah Ennis
Publikováno v: Inflammatory Bowel Diseases. 29:511-521
Background Crohn’s disease (CD) is highly heterogenous and may be complicated by stricturing behavior. Personalized prediction of stricturing will inform management. We aimed to create a stricturing risk stratification model using genomic/clinical
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fa27a03a7371ed1e2202ac17128f92c4
https://doi.org/10.1093/ibd/izac205
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3
Incidence and Prevalence of Paediatric Inflammatory Bowel Disease Continues to Increase in the South of England
Autor: James J. Ashton, Farah M. Barakat, Claire Barnes, Tracy A.F. Coelho, Akshay Batra, Nadeem A. Afzal, R. Mark Beattie
Publikováno v: Journal of Pediatric Gastroenterology & Nutrition. 75:e20-e24
Objective: The incidence of paediatric inflammatory bowel disease (IBD) has been increasing over 25 years; however, contemporary trends are not established and the impact of COVID-19 on case rates is unclear. Methods: Data from Southampton Children's
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b62b6cc712dc46ddf1d4b54ef16fa2b3
https://doi.org/10.1097/mpg.0000000000003511
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4
An atypical presentation of a pathogenic STK11 gene variant in siblings not fulfilling the clinical diagnostic criteria for Peutz-Jeghers Syndrome
Autor: Nadeem A. Afzal, Lucy Side, Justin H Davies, Meera Shaunak
Publikováno v: Journal of Pediatric Endocrinology and Metabolism. 35:131-134
Objectives To report an atypical presentation of a pathogenic STK11 gene variant in siblings not fulfilling the clinical diagnostic criteria for Peutz-Jeghers Syndrome (PJS). Case presentation Two siblings presented with prepubertal gynaecomastia and
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::bb29b7dfaced635bb7f141aa6f05314d
https://doi.org/10.1515/jpem-2021-0567
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8
Use of Biosimilars in Pediatric Inflammatory Bowel Disease: An Updated Position Statement of the Pediatric IBD Porto Group of ESPGHAN
Autor: Harland S. Winter, Jorge Amil Dias, Claudio Romano, Malgorzata Sladek, Arnold G. Vulto, Victorien M. Wolters, Paolo Lionetti, Amit Assa, Gábor Veres, Almuthe C. Hauer, Caterina Strisciuglio, Lissy de Ridder, Richard K. Russell, Daniela Knafelz, Jiri Bronsky, Nadeem A. Afzal
Publikováno v: Journal of Pediatric Gastroenterology and Nutrition, 68(1), 144-153. Lippincott Williams & Wilkins
Journal of Pediatric Gastroenterology and Nutrition, 68(1), 144. Lippincott Williams and Wilkins
Biologic therapies have changed the outcome of both adult and pediatric patients with Inflammatory Bowel Disease (IBD). In September 2013, the first biosimilar of infliximab was introduced into the pharmaceutical market. In 2015, a first position pap
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0b212099309df36850facd11b2c4f118
https://doi.org/10.1097/mpg.0000000000002141
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9
P47 Setting up a regional home calprotectin service during the COVID-19 pandemic offering hospital-based testing to local and regional paediatric IBD patients in Wessex
Autor: Robert Mark Beattie, Chris Roberts, Nadeem A. Afzal, Tracy Coelho, Akshay Batra, Claire Barnes, Efrem Eren, Jo Ward
Publikováno v: Poster presentations.
Background The first wave of the COVID-19 pandemic in the UK severely restricted our regional paediatric GI outpatient services affecting our ability to assess patients in hospital, further compounded by distance of travel of patients (An audit form
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::b80838212716e87aaf6fd1734c84c8ed
https://doi.org/10.1136/flgastro-2021-bspghan.56
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P60 Ustekinumab is an effective drug for steroid-free remission in children with refractory IBD and anti TNF-alpha induced psoriasis
Autor: Farah M Barakat, Jonathan Baker, Tracy Coelho, Claire Barnes, Akshay Batra, Nadeem A. Afzal, R Mark Beattie
Publikováno v: Poster presentations.
Background Management of paediatric Crohn’s disease (CD) presents significant challenges. Escalation of therapy to biologics or a ‘top-down’ approach, with early introduction of biologics, is common. Anti-TNF agents are widely used, but the use
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::e5bf4c05243794ec3c15739c5069df01
https://doi.org/10.1136/flgastro-2021-bspghan.69
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