Heterocycle-Based Multicomponent Reactions in Drug Discovery: From Hit Finding to Rational Design

Autor: Pau Nadal Rodríguez, Ouldouz Ghashghaei, Andrea Bagán, Carmen Escolano, Rodolfo Lavilla

Publikováno v: Biomedicines, Vol 10, Iss 7, p 1488 (2022)

In the context of the structural complexity necessary for a molecule to selectively display a therapeutical action and the requirements for suitable pharmacokinetics, a robust synthetic approach is essential. Typically, thousands of relatively simila

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Charting the Chemical Reaction Space around a Multicomponent Combination: Controlled Access to a Diverse Set of Biologically Relevant Scaffolds.

Autor: Nadal Rodríguez P; Department of Medicinal Chemistry Faculty of Pharmacy and Food Sciences University of Barcelona and Institute of Biomedicine UB (IBUB) Av. De Joan XXIII, 27-31 08028 Barcelona Spain., Ghashghaei O; Department of Medicinal Chemistry Faculty of Pharmacy and Food Sciences University of Barcelona and Institute of Biomedicine UB (IBUB) Av. De Joan XXIII, 27-31 08028 Barcelona Spain., Schoepf AM; Department of Medicinal Chemistry Faculty of Pharmacy and Food Sciences University of Barcelona and Institute of Biomedicine UB (IBUB) Av. De Joan XXIII, 27-31 08028 Barcelona Spain., Benson S; Centre for Inflammation Research The University of Edinburgh Edinburgh UK., Vendrell M; Centre for Inflammation Research The University of Edinburgh Edinburgh UK., Lavilla R; Department of Medicinal Chemistry Faculty of Pharmacy and Food Sciences University of Barcelona and Institute of Biomedicine UB (IBUB) Av. De Joan XXIII, 27-31 08028 Barcelona Spain.

Publikováno v: Angewandte Chemie (Weinheim an der Bergstrasse, Germany) [Angew Chem Weinheim Bergstr Ger] 2023 Oct 09; Vol. 135 (41), pp. e202303889. Date of Electronic Publication: 2023 Jun 02.

Ugi Four-Component Reactions Using Alternative Reactants.

Autor: Hooshmand, Seyyed Emad¹ (AUTHOR), Zhang, Wei² (AUTHOR) wei2.zhang@umb.edu

Publikováno v: Molecules. Feb2023, Vol. 28 Issue 4, p1642. 17p.