Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Nada S. Aboelella"'
Publikováno v:
Frontiers in Immunology, Vol 11 (2021)
Cyclophosphamide (CTX) is a major component of the chemotherapy conditioning regimens used in the clinic to prepare cancer patients for hematopoietic stem cell transplantation or adoptive T cell therapy. Previous studies have shown that CTX given at
Externí odkaz:
https://doaj.org/article/3421a30b17504bd98866e5f8b47e1590
Publikováno v:
Cancers, Vol 13, Iss 5, p 986 (2021)
It has been well-established that cancer cells are under constant oxidative stress, as reflected by elevated basal level of reactive oxygen species (ROS), due to increased metabolism driven by aberrant cell growth. Cancer cells can adapt to maintain
Externí odkaz:
https://doaj.org/article/fe9c1d79abc44638bde7e36dab66306a
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 11, Iss Suppl 1 (2023)
Externí odkaz:
https://doaj.org/article/1377fca80fb84d02ad316901b58e725c
Autor:
Nada S Aboelella, Caitlin Brandle, Ogacheko Okoko, Md Yeashin Gazi, Zhi-Chun Ding, Hongyan Xu, Gregory Gorman, Roni Bollag, Marco L Davila, Locke J Bryan, David H Munn, Gary A Piazza, Gang Zhou
Publikováno v:
Journal for immunotherapy of cancer. 10(7)
BackgroundAdoptive cell therapy (ACT) using genetically modified T cells has evolved into a promising treatment option for patients with cancer. However, even for the best-studied and clinically validated CD19-targeted chimeric antigen receptor (CAR)
Autor:
Nada S. Aboelella, Gang Zhou
Publikováno v:
The Journal of Immunology. 208:117.01-117.01
Adoptive T cell therapy (ACT) has shown promising therapeutic outcomes in patients with hematological malignancies. However, the success of ACT is limited to a small fraction of treated patients. Hence, developing new strategies to enhance the potenc
Autor:
Richard A. McIndoe, Eun Jeong Park, David H. Munn, Nada S. Aboelella, Gary A. Piazza, Zhuoqi Liu, Hongyan Xu, Jiaqi Li, Lirong Pei, Kateryna Fesenkova, Bruce R. Blazar, Zhi-Chun Ding, Gang Zhou, Huidong Shi
Publikováno v:
Sci Immunol
The presence of polyfunctional CD4(+) T cells is often associated with favorable antitumor immunity. We report here that persistent activation of signal transducer and activator of transcription 5 (STAT5) in tumor-specific CD4(+) T cells drives the d
Autor:
Xi Chen, Gang Zhou, Michael R. Boyd, Nada S. Aboelella, Donald J. Buchsbaum, Antonio Ward, Yulia Maxuitenko, Alex Coley, Gary A. Piazza, Adam B. Keeton
Publikováno v:
Drug Discov Today
Although numerous reports conclude that nonsteroidal anti-inflammatory drugs (NSAIDs) have anticancer activity, this common drug class is not recommended for long-term use because of potentially fatal toxicities from cyclooxygenase (COX) inhibition.
Publikováno v:
Cancers, Vol 13, Iss 986, p 986 (2021)
Cancers
Cancers
Simple Summary Cancer cells are consistently under oxidative stress, as reflected by elevated basal level of reactive oxygen species (ROS), due to increased metabolism driven by aberrant cell growth. This feature has been exploited to develop therape
Publikováno v:
Cancer Research. 79:4095-4095
Cancer cells face increased oxidative stress driven by oncogene activation, tumor suppressor gene mutation and increased metabolism. Even though cancer cells can resist this redox imbalance by activating various antioxidant defense mechanisms, they a
Autor:
Gang Zhou, David H Munn, Zhi-Chun Ding, Marco L Davila, Hongyan Xu, Nada S Aboelella, Caitlin Brandle, Ogacheko Okoko, Md Yeashin Gazi, Gregory Gorman, Roni Bollag, Locke J Bryan, Gary A Piazza
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 10, Iss 7 (2022)
Background Adoptive cell therapy (ACT) using genetically modified T cells has evolved into a promising treatment option for patients with cancer. However, even for the best-studied and clinically validated CD19-targeted chimeric antigen receptor (CAR
Externí odkaz:
https://doaj.org/article/a814f619a9934bacafbe74860b95a4f2