Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Nada S Alakhras"'
Autor:
Nada S. Alakhras, Christopher A. Moreland, Li Chin Wong, Priyam Raut, Sid Kamalakaran, Yi Wen, Robert W. Siegel, Laurent P. Malherbe
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
Recombinant adeno-associated virus (AAV) vectors have emerged as the preferred platform for gene therapy of rare human diseases. Despite the clinical promise, host immune responses to AAV vectors and transgene remain a major barrier to the developmen
Externí odkaz:
https://doaj.org/article/5d526ac1f027445c881a5c370ba6217e
Autor:
Pegah Mehrpouya-Bahrami, Alina K. Moriarty, Paulo De Melo, W. Coles Keeter, Nada S. Alakhras, Andrew S. Nelson, Madeline Hoover, Maria S. Barrios, Jerry L. Nadler, C. Henrique Serezani, Mark H. Kaplan, Elena V. Galkina
Publikováno v:
JCI Insight, Vol 6, Iss 14 (2021)
Signal transducer and activator of transcription 4 (STAT4) is expressed in hematopoietic cells and plays a key role in the differentiation of T helper 1 cells. Although STAT4 is required for immunity to intracellular pathogens, the T cell–independe
Externí odkaz:
https://doaj.org/article/b83149859da34de388f9135a72903011
Autor:
Leonardo Augusto, Jennifer Martynowicz, Parth H. Amin, Nada S. Alakhras, Mark H. Kaplan, Ronald C. Wek, William J. Sullivan
Publikováno v:
mBio, Vol 11, Iss 4 (2020)
ABSTRACT Toxoplasma gondii is an intracellular parasite that reconfigures its host cell to promote pathogenesis. One consequence of Toxoplasma parasitism is increased migratory activity of host cells, which facilitates dissemination. Here, we show th
Externí odkaz:
https://doaj.org/article/3d630c390fc84de5b6a66b41628efa5f
Autor:
Nada S. Alakhras, Mark H. Kaplan
Publikováno v:
Advanced Biology.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::064df85819496cfd8d4de4dc69c87c50
https://doi.org/10.1002/adbi.202300073
https://doi.org/10.1002/adbi.202300073
Autor:
Nada S. Alakhras, Jaeho Shin, Scott A. Smith, Anthony L. Sinn, Wenwu Zhang, Gyoyeon Hwang, Jenna Sjoerdsma, Emily K. Bromley, Karen E. Pollok, Basar Bilgicer, Mark H. Kaplan
Publikováno v:
Science Translational Medicine. 15
Peanut-induced allergy is an immunoglobulin E (IgE)–mediated type I hypersensitivity reaction that manifests symptoms ranging from local edema to life-threatening anaphylaxis. Although there are treatments for symptoms in patients with allergies re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1224036f74dab6d7a366003cb14cd5d5
https://doi.org/10.1126/scitranslmed.add6373
https://doi.org/10.1126/scitranslmed.add6373
Autor:
C. Henrique Serezani, Jerry L. Nadler, Elena V. Galkina, Nada S Alakhras, Mark H. Kaplan, Madeline Hoover, Paulo De Melo, Pegah Mehrpouya-Bahrami, W. Coles Keeter, Alina K. Moriarty, Maria S Barrios, Andrew S Nelson
Publikováno v:
JCI Insight
Signal transducer and activator of transcription 4 (STAT4) is expressed in hematopoietic cells and plays a key role in the differentiation of T helper 1 cells. Although STAT4 is required for immunity to intracellular pathogens, the T cell-independent
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e448a4e07ff0aeb471dc332be44eb95a
http://europepmc.org/articles/PMC8410094
http://europepmc.org/articles/PMC8410094
Autor:
Nada S. Alakhras, Ronald C. Wek, Mark H. Kaplan, Jennifer Martynowicz, William J. Sullivan, Parth B. Amin, Leonardo Augusto
Publikováno v:
mBio, Vol 11, Iss 4 (2020)
mBio
mBio
Cells that are infected with the parasite Toxoplasma gondii exhibit heightened migratory activity, which facilitates dissemination of the infection throughout the body. In this report, we identify a new mechanism used by Toxoplasma to hijack its host
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bc21697a91ea07444b47f3d1fba1fcde
Autor:
Jinsam You, Kyla Driscoll, Jeffrey A. Willy, Laurent Malherbe, Anja Koester, Derrick R. Witcher, Rikke B. Holmgaard, Guilherme Rocha, Jiabin Qiu, Nada S Alakhras, David Schaer
Publikováno v:
mAbs. 10(6)
Immunomodulatory monoclonal IgG1 antibodies developed for cancer and autoimmune disease have an inherent risk of systemic release of pro-inflammatory cytokines. In vitro cytokine release assays are currently used to predict cytokine release syndrome
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::87b1374f97c8b8f41de77e924d67ad7e
https://pubmed.ncbi.nlm.nih.gov/29953319
https://pubmed.ncbi.nlm.nih.gov/29953319