Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Nada Kuk"'
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-12 (2017)
Abstract The mechanics of DNA replication and cell cycling are well-characterized in model organisms, but less is known about these basic aspects of cell biology in early-diverging Apicomplexan parasites, which do not divide by canonical binary fissi
Externí odkaz:
https://doaj.org/article/23ef27017c93437bb385de1aeb7f53c9
Autor:
Antoine Claessens, Lynne M Harris, Slavica Stanojcic, Lia Chappell, Adam Stanton, Nada Kuk, Pamela Veneziano-Broccia, Yvon Sterkers, Julian C Rayner, Catherine J Merrick
Publikováno v:
PLoS Genetics, Vol 14, Iss 7, p e1007490 (2018)
The malaria parasite Plasmodium falciparum has evolved an unusual genome structure. The majority of the genome is relatively stable, with mutation rates similar to most eukaryotic species. However, some regions are very unstable with high recombinati
Externí odkaz:
https://doaj.org/article/7d4cdc43a6e547ebbcf08ca74b449fcd
Autor:
Gabriel H Negreira, Pieter Monsieurs, Hideo Imamura, Ilse Maes, Nada Kuk, Akila Yagoubat, Frederik Van den Broeck, Yvon Sterkers, Jean-Claude Dujardin, Malgorzata A Domagalska
Publikováno v:
Nucleic Acids Research
Nucleic Acids Research, 2022, 50 (1), pp.293-305. ⟨10.1093/nar/gkab1203⟩
Nucleic acids research
Nucleic Acids Research, 2022, 50 (1), pp.293-305. ⟨10.1093/nar/gkab1203⟩
Nucleic acids research
Leishmania, a unicellular eukaryotic parasite, is a unique model for aneuploidy and cellular heterogeneity, along with their potential role in adaptation to environmental stresses. Somy variation within clonal populations was previously explored in a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a1558a0980edecac985415a3a56f21db
https://hal.science/hal-03675646/file/gkab1203.pdf
https://hal.science/hal-03675646/file/gkab1203.pdf
Autor:
Rosa Milagros Corrales, Yvon Sterkers, Patrick Bastien, Julio Mateos-Langerak, Rachel Neish, Nada Kuk, Slavica Vaselek, Derrick R. Robinson, Laurence Berry, Jeremy C. Mottram, Lucien Crobu, Camille D. Brunet, Petr Volf
Publikováno v:
PLoS Pathogens
PLoS Pathogens, Public Library of Science, 2021, 17 (6), pp.e1009666. ⟨10.1371/journal.ppat.1009666⟩
PLoS Pathogens, 2021, 17 (6), pp.e1009666. ⟨10.1371/journal.ppat.1009666⟩
PLOS Pathogens
PLoS Pathogens, Vol 17, Iss 6, p e1009666 (2021)
PLoS Pathogens, Public Library of Science, 2021, 17 (6), pp.e1009666. ⟨10.1371/journal.ppat.1009666⟩
PLoS Pathogens, 2021, 17 (6), pp.e1009666. ⟨10.1371/journal.ppat.1009666⟩
PLOS Pathogens
PLoS Pathogens, Vol 17, Iss 6, p e1009666 (2021)
Leishmania parasites possess a unique and complex cytoskeletal structure termed flagellum attachment zone (FAZ) connecting the base of the flagellum to one side of the flagellar pocket (FP), an invagination of the cell body membrane and the sole site
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9151426901991ff895d9ca957e8f31c5
https://hal.umontpellier.fr/hal-03299396
https://hal.umontpellier.fr/hal-03299396
Autor:
Hideo Imamura, Van den Broeck F, Nada Kuk, Pieter Monsieurs, Malgorzata A. Domagalska, Ilse Maes, Yagoubat A, Yvon Sterkers, Negreira Gh, Jean-Claude Dujardin
Leishmania, a unicellular eukaryotic parasite, is a unique model for aneuploidy and cellular heterogeneity, along with their potential role in adaptation to environmental stresses. Somy variation within clonal populations was previously explored in a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6889076426840c86f0d85d8a6b36ba07
https://doi.org/10.1101/2021.05.11.443577
https://doi.org/10.1101/2021.05.11.443577
Autor:
Negreira Gh, Ilse Maes, Hideo Imamura, Pieter Monsieurs, Nada Kuk, Yvon Sterkers, Jean-Claude Dujardin, Yagoubat A, Van den Broeck F, Malgorzata A. Domagalska
Maintenance of stable ploidy over continuous mitotic events is a paradigm for most higher eukaryotes. Defects in chromosome segregation and/or replication can lead to aneuploidy, a condition often considered deleterious. However, in Leishmania, a Pro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1bd12e9a35db2b83d2abb23a0385e0e2
Autor:
Laurence Berry, Michèle Lefebvre, Lucien Crobu, Amélie Sarrazin, Nada Kuk, Yvon Sterkers, Patrick Bastien, Akila Yagoubat
Publikováno v:
Cellular Microbiology
Cellular Microbiology, Wiley, In press, ⟨10.1111/cmi.13159⟩
Cellular Microbiology, In press, ⟨10.1111/cmi.13159⟩
Cellular Microbiology, Wiley, In press, ⟨10.1111/cmi.13159⟩
Cellular Microbiology, In press, ⟨10.1111/cmi.13159⟩
International audience; Trypanosomatids are divergent eukaryotes of high medical and economical relevance. Their biology exhibits original features that remain poorly understood; particularly, Leishmania is known for its high degree of genomic plasti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::63f882f2d39c401735fa8fdb13e512df
https://hal.umontpellier.fr/hal-02499098/document
https://hal.umontpellier.fr/hal-02499098/document
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-12 (2017)
Scientific Reports
Scientific Reports, Nature Publishing Group, 2017, 7 (1), pp.4003. ⟨10.1038/s41598-017-04407-z⟩
Scientific Reports, 2017, 7 (1), pp.4003. ⟨10.1038/s41598-017-04407-z⟩
Scientific Reports
Scientific Reports, Nature Publishing Group, 2017, 7 (1), pp.4003. ⟨10.1038/s41598-017-04407-z⟩
Scientific Reports, 2017, 7 (1), pp.4003. ⟨10.1038/s41598-017-04407-z⟩
The mechanics of DNA replication and cell cycling are well-characterized in model organisms, but less is known about these basic aspects of cell biology in early-diverging Apicomplexan parasites, which do not divide by canonical binary fission but un
Autor:
Lauriane Sollelis, Cameron Ross MacPherson, Yvon Sterkers, Artur Scherf, Patrick Bastien, Slavica Stanojcic, Michel Pagès, Frédéric Bringaud, Lucien Crobu, Maria-Rosa Garcia-Silva, Nada Kuk
Publikováno v:
EMBO Reports
EMBO Reports, EMBO Press, 2017, 18 (11), pp.1968-1977. ⟨10.15252/embr.201744216⟩
EMBO Reports, 2017, 18 (11), pp.1968-1977. ⟨10.15252/embr.201744216⟩
EMBO Reports, EMBO Press, 2017, 18 (11), pp.1968-1977. ⟨10.15252/embr.201744216⟩
EMBO Reports, 2017, 18 (11), pp.1968-1977. ⟨10.15252/embr.201744216⟩
International audience; Leishmania affects millions of people worldwide. Its genome undergoes constitutive mosaic aneuploidy, a type of genomic plasticity that may serve as an adaptive strategy to survive distinct host environments. We previously fou
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::da2edd50c144359ae35d3645bc70db8b
https://hal.archives-ouvertes.fr/hal-01745219
https://hal.archives-ouvertes.fr/hal-01745219
Autor:
Mehdi Ghorbal, Jose-Juan Lopez-Rubio, Nada Kuk, Lucien Crobu, Artur Scherf, Lauriane Sollelis, Rafael M. Martins, Cameron Ross MacPherson, Yvon Sterkers, Patrick Bastien
Publikováno v:
Cellular Microbiology. 17:1405-1412
Protozoan pathogens that cause leishmaniasis in humans are relatively refractory to genetic manipulation. In this work, we implemented the CRISPR-Cas9 system in Leishmania parasites and demonstrated its efficient use for genome editing. The Cas9 endo