Zobrazeno 1 - 9 of 9 pro vyhledávání: '"Nada Alsakhen"'
1
Akademický článek
Discovery of 1-(5-bromopyrazin-2-yl)-1-[3-(trifluoromethyl)benzyl]urea as a promising anticancer drug via synthesis, characterization, biological screening, and computational studies
Autor: Yasser Hussein Issa Mohammed, Israa M. Shamkh, Nahed S. Alharthi, Mohammed A. Shanawaz, Hind A. Alzahrani, Basit Jabbar, Saba Beigh, Saad Alghamdi, Nada Alsakhen, Elshiekh B. Khidir, Hayaa M. Alhuthali, Taqwa Hafiz Elamin Karamalla, Amgad M. Rabie
Publikováno v: Scientific Reports, Vol 13, Iss 1, Pp 1-20 (2023)
Abstract Cancer and different types of tumors are still the most resistant diseases to available therapeutic agents. Finding a highly effective anticancer drug is the first target and concern of thousands of drug designers. In our attempts to address
Externí odkaz: https://doaj.org/article/07a6f877a2444e2dad96c9bb8bc9e27b
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2
Akademický článek
Isoform switching leads to downregulation of cytokine producing genes in estrogen receptor positive breast cancer
Autor: Mohammad Shahbaz Khan, Waqar Hanif, Nada Alsakhen, Basit Jabbar, Israa M. Shamkh, Ahad Amer Alsaiari, Mazen Almehmadi, Saad Alghamdi, Afnan Shakoori, Dunia A. Al Farraj, Saeedah Musaed Almutairi, Yasser Hussein Issa Mohammed, Amr S. Abouzied, Aziz-Ur Rehman, Bader Huwaimel
Publikováno v: Frontiers in Genetics, Vol 14 (2023)
Objective: Estrogen receptor breast cancer (BC) is characterized by the expression of estrogen receptors. It is the most common cancer among women, with an incidence rate of 2.26 million cases worldwide. The aim of this study was to identify differen
Externí odkaz: https://doaj.org/article/775d08f6ce304aefbf9517fa7ffaf5b6
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6
In silico identification of 1,2,4-triazoles as potential Candida Albicans inhibitors using 3D-QSAR, molecular docking, molecular dynamics simulations, and ADMET profiling
Autor: Soukaina Bouamrane, Ayoub Khaldan, Halima Hajji, Reda El-mernissi, Marwa Alaqarbeh, Nada Alsakhen, Hamid Maghat, Mohammed Aziz Ajana, Abdelouahid Sbai, Mohammed Bouachrine, Tahar Lakhlifi
Publikováno v: Molecular diversity.
Fluconazole and Voriconazole are individual antifungal inhibitors broadly adopted for treating fungal infections, including Candida Albicans. Unfortunately, these medicines clinically used have significant side effects. Consequently, the improvement
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::66a3cb2c739d85aef926f095e59ed30c
https://pubmed.ncbi.nlm.nih.gov/36239842
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7
Computational approach investigation bioactive molecules from Saussurea Costus plant as SARS-CoV-2 main protease inhibitors using reverse docking, molecular dynamics simulation, and pharmacokinetic ADMET parameters
Autor: Halima Hajji, Marwa Alaqarbeh, Tahar Lakhlifi, Mohammed Aziz Ajana, Nada Alsakhen, Mohammed Bouachrine
Publikováno v: Computers in biology and medicine. 150
SARS-COV-2 virus causes (COVID-19) disease; it has become a global pandemic since 2019 and has negatively affected all aspects of human life. Scientists have made great efforts to find a reliable cure, vaccine, or treatment for this emerging disease.
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d4a2c3574abbed17135fd71c268f3be2
https://pubmed.ncbi.nlm.nih.gov/36257276
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