Zobrazeno 1 - 10
of 11
pro vyhledávání: '"Nada Abuarab"'
Publikováno v:
Molecular & Cellular Oncology, Vol 4, Iss 6 (2017)
In age-related diseases, rise in intracellular reactive oxygen species (ROS) causes fragmentation of mitochondrial network. Our recent study demonstrated that ROS activation of TRPM2 (transient receptor potential melastatin-2) channels triggers lysos
Externí odkaz:
https://doaj.org/article/120e8cecd5d341ada03f2a4a2713021f
Autor:
Rucha Karnik, Melanie J Ludlow, Nada Abuarab, Andrew J Smith, Matthew E L Hardy, David J S Elliott, Asipu Sivaprasadarao
Publikováno v:
PLoS ONE, Vol 8, Iss 12, p e85630 (2013)
The hERG potassium channel is critical for repolarisation of the cardiac action potential. Reduced expression of hERG at the plasma membrane, whether caused by hereditary mutations or drugs, results in long QT syndrome and increases the risk of ventr
Externí odkaz:
https://doaj.org/article/4b098201bb4e49979d0c500ef772d6d1
Publikováno v:
International Journal of Innovation and Learning. 1:1
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::89d612ccadd9ed4c4b0f4b6b484d271b
https://doi.org/10.1504/ijil.2023.10046428
https://doi.org/10.1504/ijil.2023.10046428
Mitochondria, traditionally known for their role in power (ATP) generation, are important signalling organelles. To support these vital functions, mitochondria need to undergo continuous remodellin...
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::358d2650fc240e46ad80efc2bce92ca6
https://eprints.whiterose.ac.uk/121498/1/19336950.2017.pdf
https://eprints.whiterose.ac.uk/121498/1/19336950.2017.pdf
Publikováno v:
Science Signaling. 10
Diabetic stress increases the production of reactive oxygen species (ROS), leading to mitochondrial fragmentation and dysfunction. We hypothesized that ROS-sensitive TRPM2 channels mediated diabetic stress-induced mitochondrial fragmentation. We foun
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::30908e226e29f796f46c8770e0018951
https://doi.org/10.1126/scisignal.aal4161
https://doi.org/10.1126/scisignal.aal4161
Publikováno v:
Journal of Cell Science.
Cell migration is a fundamental feature of tumour metastasis and angiogenesis. It is regulated by a variety of signalling molecules including H2O2 and Ca(2+) Here, we asked whether the H2O2-sensitive transient receptor potential melastatin 2 (TRPM2)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3eb3ba5e619b334fc41ff5b56c2ab2f8
https://doi.org/10.1242/jcs.179796
https://doi.org/10.1242/jcs.179796
Publikováno v:
Oncotarget
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9c878974281ff6f2d13863aca933d302
https://doi.org/10.18632/oncotarget.21391
https://doi.org/10.18632/oncotarget.21391
Publikováno v:
Journal of cell science. 129(10)
Cell migration is a fundamental feature of tumour metastasis and angiogenesis. It is regulated by a variety of signalling molecules including H2O2 and Ca(2+) Here, we asked whether the H2O2-sensitive transient receptor potential melastatin 2 (TRPM2)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3349284b9e9b24303209e7b204b7fa3a
https://pubmed.ncbi.nlm.nih.gov/27068538
https://pubmed.ncbi.nlm.nih.gov/27068538
Autor:
Paul T, Manna, Tim S, Munsey, Nada, Abuarab, Fangfang, Li, Aruna, Asipu, Gareth, Howell, Alicia, Sedo, Wei, Yang, Jacqui, Naylor, David J, Beech, Lin-Hua, Jiang, Asipu, Sivaprasadarao
Publikováno v:
The Biochemical journal. 466(3)
Reactive oxygen species (ROS) can cause pancreatic β-cell death by activating transient receptor potential (melastatin) 2 (TRPM2) channels. Cell death has been attributed to the ability of these channels to raise cytosolic Ca2+. Recent studies howev
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::3603b5493486705ab7a73211d6d59cf2
https://pubmed.ncbi.nlm.nih.gov/25562606
https://pubmed.ncbi.nlm.nih.gov/25562606
Publikováno v:
Molecular & Cellular Oncology. 4:e1373889
In age-related diseases, rise in intracellular reactive oxygen species (ROS) causes fragmentation of mitochondrial network. Our recent study demonstrated that ROS activation of TRPM2 (transient receptor potential melastatin-2) channels triggers lysos
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b5bc3f1109e923cf213b7e46a961ee6f
https://doi.org/10.1080/23723556.2017.1373889
https://doi.org/10.1080/23723556.2017.1373889