Zobrazeno 1 - 10
of 49
pro vyhledávání: '"Nada, Lallous"'
Autor:
Nader Al-Nakouzi, Chris Kedong Wang, Htoo Zarni Oo, Irina Nelepcu, Nada Lallous, Charlotte B. Spliid, Nastaran Khazamipour, Joey Lo, Sarah Truong, Colin Collins, Desmond Hui, Shaghayegh Esfandnia, Hans Adomat, Thomas Mandel Clausen, Tobias Gustavsson, Swati Choudhary, Robert Dagil, Eva Corey, Yuzhuo Wang, Anne Chauchereau, Ladan Fazli, Jeffrey D. Esko, Ali Salanti, Peter S. Nelson, Martin E. Gleave, Mads Daugaard
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-14 (2022)
Chondroitin sulfate (CS) is one of the most abundant glycosaminoglycans in prostate cancers. Here the authors show that inhibition of the androgen receptor pathway leads to the upregulation of CS, which promotes prostate cancer growth and metastasis.
Externí odkaz:
https://doaj.org/article/22e286a19f144d4daece67eee9f8ec9e
Autor:
Tunç Morova, Daniel R. McNeill, Nada Lallous, Mehmet Gönen, Kush Dalal, David M. Wilson, Attila Gürsoy, Özlem Keskin, Nathan A. Lack
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-10 (2020)
Androgen receptor (AR) mediated transcription is critical to prostate tumorigenesis and development. Here, utilising clinical whole genome sequencing data, the authors show that the non-coding AR binding sites on DNA are frequently mutated in prostat
Externí odkaz:
https://doaj.org/article/15a98cfbbcff421a8c1487325afd7722
Autor:
Mariia Radaeva, Huifang Li, Eric LeBlanc, Kush Dalal, Fuqiang Ban, Fabrice Ciesielski, Bonny Chow, Helene Morin, Shannon Awrey, Kriti Singh, Paul S. Rennie, Nada Lallous, Artem Cherkasov
Publikováno v:
Cells, Vol 11, Iss 18, p 2785 (2022)
The mutation-driven transformation of clinical anti-androgen drugs into agonists of the human androgen receptor (AR) represents a major challenge for the treatment of prostate cancer patients. To address this challenge, we have developed a novel clas
Externí odkaz:
https://doaj.org/article/4aa1ebf257e04f9f8d6c4c6190d87376
Autor:
Victor M. Matias-Barrios, Mariia Radaeva, Yi Song, Zaccary Alperstein, Ahn R. Lee, Veronika Schmitt, Joseph Lee, Fuqiang Ban, Ning Xie, Jianfei Qi, Nada Lallous, Martin E. Gleave, Artem Cherkasov, Xuesen Dong
Publikováno v:
Frontiers in Oncology, Vol 10 (2021)
Poison inhibitors of DNA topoisomerase II (TOP2) are clinically used drugs that cause cancer cell death by inducing DNA damage, which mechanism of action is also associated with serious side effects such as secondary malignancy and cardiotoxicity. In
Externí odkaz:
https://doaj.org/article/e540c6f93470479eae4a4308cd7ca9c6
Autor:
Fan Zhang, Maitree Biswas, Shabnam Massah, Joseph Lee, Shreyas Lingadahalli, Samantha Wong, Christopher Wells, Jane Foo, Nabeel Khan, Helene Morin, Neetu Saxena, Sonia H Y Kung, Bei Sun, Ana Karla Parra Nuñez, Christophe Sanchez, Novia Chan, Lauren Ung, Umut Berkay Altıntaş, Jennifer M Bui, Yuzhuo Wang, Ladan Fazli, Htoo Zarni Oo, Paul S Rennie, Nathan A Lack, Artem Cherkasov, Martin E Gleave, Jörg Gsponer, Nada Lallous
Publikováno v:
Nucleic Acids Research. 51:99-116
Numerous cancers, including prostate cancer (PCa), are addicted to transcription programs driven by specific genomic regions known as super-enhancers (SEs). The robust transcription of genes at such SEs is enabled by the formation of phase-separated
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::04ef45e5bfa83df55e5467735f7f6cc2
https://doi.org/10.1093/nar/gkac1158
https://doi.org/10.1093/nar/gkac1158
Autor:
Mariia Radaeva, Helene Morin, Mohit Pandey, Fuqiang Ban, Maria Guo, Eric LeBlanc, Nada Lallous, Artem Cherkasov
Publikováno v:
Molecular Informatics.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e2c7bf0aa76ae26ee94212493c7931c7
https://doi.org/10.1002/minf.202300026
https://doi.org/10.1002/minf.202300026
Publikováno v:
Database. 2023
The isolation of proteins of interest from cell lysates is an integral step to study protein structure and function. Liquid chromatography is a technique commonly used for protein purification, where the separation is performed by exploiting the diff
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3cb0bd110227b1a790aadd7e938450d4
https://doi.org/10.1093/database/baad016
https://doi.org/10.1093/database/baad016
Autor:
Mark R. Flory, Gang Chen, Matthew E.K. Chang, Martin E. Gleave, Chia-Chi Flora Huang, Robert N. Young, Nathan A. Lack, Fariba Ghaidi, Hélène Morin, Fuqiang Ban, Shreyas Lingadahalli, Ayse Derya Cavga, Ivan Pak Lok Yu, Sam Lawn, Sankar Mohan, Eric Leblanc, Paul S. Rennie, Nada Lallous, Artem Cherkasov, Hisham Mohammed
Publikováno v:
Journal of Medicinal Chemistry. 64:14968-14982
Prostate cancer (PCa) patients undergoing androgen deprivation therapy almost invariably develop castration-resistant prostate cancer (CRPC). Targeting the androgen receptor (AR) Binding Function-3 (BF3) site offers a promising option to treat CRPC.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::14b91d3724dbece00ac2581591827012
https://doi.org/10.1021/acs.jmedchem.1c00681
https://doi.org/10.1021/acs.jmedchem.1c00681
Autor:
Louise Ramos, Sarah Truong, Beibei Zhai, Jay Joshi, Fariba Ghaidi, Michael M. Lizardo, Taras Shyp, Hans Adomat, Stephane Le Bihan, Colin Collins, Jeffrey Bacha, Dennis Brown, John Langlands, Wang Shen, Nada Lallous, Poul H. Sorensen, Mads Daugaard
HDAC inhibition has been shown to induce pharmacological BRCAness in cancer cells with proficient DNA repair activity. This provides a rationale for exploring combination treatments with HDAC and PARP inhibition in cancer types that are insensitive t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8532b45aa4cc777dac59e99066efd4a6
https://doi.org/10.1101/2022.11.10.515994
https://doi.org/10.1101/2022.11.10.515994
Autor:
Lavinia A. Carabet, Eric Leblanc, Nada Lallous, Helene Morin, Fariba Ghaidi, Joseph Lee, Paul S. Rennie, Artem Cherkasov
Publikováno v:
Molecules, Vol 24, Iss 4, p 763 (2019)
The heterogeneous nuclear ribonucleoprotein A1 (hnRNP A1) is a versatile RNA-binding protein playing a critical role in alternative pre-mRNA splicing regulation in cancer. Emerging data have implicated hnRNP A1 as a central player in a splicing regul
Externí odkaz:
https://doaj.org/article/80d2c9dafe284d928e46040c3a37af97