Mechanistic Studies and In Vivo Efficacy of an Oxadiazole-Containing Antibiotic.

Autor: Naclerio GA; Chemistry Department, Institute for Drug Discovery, Purdue University, West Lafayette, Indiana 47907, United States., Abutaleb NS; Department of Biomedical Sciences and Pathobiology, Virginia-Maryland College of Veterinary Medicine, Virginia Polytechnic Institute and State University, Blacksburg, Virginia 24060, United States.; Department of Comparative Pathobiology, College of Veterinary Medicine, Purdue University, West Lafayette, Indiana 47907, United States., Onyedibe KI; Chemistry Department, Institute for Drug Discovery, Purdue University, West Lafayette, Indiana 47907, United States.; Purdue Institute of Inflammation, Immunology, and Infectious Disease, Purdue University, West Lafayette, Indiana 47907, United States., Karanja C; Chemistry Department, Institute for Drug Discovery, Purdue University, West Lafayette, Indiana 47907, United States., Eldesouky HE; Department of Biomedical Sciences and Pathobiology, Virginia-Maryland College of Veterinary Medicine, Virginia Polytechnic Institute and State University, Blacksburg, Virginia 24060, United States.; Department of Comparative Pathobiology, College of Veterinary Medicine, Purdue University, West Lafayette, Indiana 47907, United States., Liang HW; Department of Biomedical Sciences and Pathobiology, Virginia-Maryland College of Veterinary Medicine, Virginia Polytechnic Institute and State University, Blacksburg, Virginia 24060, United States., Dieterly A; Department of Comparative Pathobiology, College of Veterinary Medicine, Purdue University, West Lafayette, Indiana 47907, United States., Aryal UK; Department of Comparative Pathobiology, College of Veterinary Medicine, Purdue University, West Lafayette, Indiana 47907, United States.; Purdue Proteomics Facility, Bindley Bioscience Center, Purdue University, West Lafayette, Indiana 47907, United States., Lyle T; Department of Comparative Pathobiology, College of Veterinary Medicine, Purdue University, West Lafayette, Indiana 47907, United States.; Center for Comparative Translational Research, Purdue University, West Lafayette, Indiana 47907, United States., Seleem MN; Department of Biomedical Sciences and Pathobiology, Virginia-Maryland College of Veterinary Medicine, Virginia Polytechnic Institute and State University, Blacksburg, Virginia 24060, United States.; Department of Comparative Pathobiology, College of Veterinary Medicine, Purdue University, West Lafayette, Indiana 47907, United States.; Center for Emerging, Zoonotic and Arthropod-borne Pathogens, Virginia Polytechnic Institute and State University, Blacksburg, Virginia 24061, United States., Sintim HO; Chemistry Department, Institute for Drug Discovery, Purdue University, West Lafayette, Indiana 47907, United States.; Purdue Institute of Inflammation, Immunology, and Infectious Disease, Purdue University, West Lafayette, Indiana 47907, United States.

Publikováno v: Journal of medicinal chemistry [J Med Chem] 2022 May 12; Vol. 65 (9), pp. 6612-6630. Date of Electronic Publication: 2022 Apr 28.

Starving Bacteria of Iron: A Potential Strategy to Disperse Bacterial Biofilms.

Autor: Naclerio GA; Chemistry Department, Institute for Drug Discovery, Purdue University, West Lafayette, Indiana 47907, United States., Sintim HO; Chemistry Department, Institute for Drug Discovery, Purdue University, West Lafayette, Indiana 47907, United States.; Purdue Institute for Inflammation, Immunology, and Infectious Diseases, Purdue University, West Lafayette, Indiana 47907, United States.

Publikováno v: Journal of medicinal chemistry [J Med Chem] 2021 Jun 10; Vol. 64 (11), pp. 7272-7274. Date of Electronic Publication: 2021 May 14.

Ultrapotent Inhibitor of Clostridioides difficile Growth, Which Suppresses Recurrence In Vivo .

Autor: Naclerio GA; Chemistry Department, Institute for Drug Discovery, Purdue University, West Lafayette, Indiana 47907, United States., Abutaleb NS; Department of Comparative Pathobiology, Purdue University College of Veterinary Medicine, West Lafayette, Indiana 47907, United States., Li D; Department of Comparative Pathobiology, Purdue University College of Veterinary Medicine, West Lafayette, Indiana 47907, United States., Seleem MN; Department of Comparative Pathobiology, Purdue University College of Veterinary Medicine, West Lafayette, Indiana 47907, United States.; Department of Biomedical Sciences and Pathobiology, Virginia-Maryland College of Veterinary Medicine, Virginia Polytechnic Institute and State University, Blacksburg, Virginia 24060, United States.; Purdue Institute of Inflammation, Immunology, and Infectious Disease, West Lafayette, Indiana 47907, United States., Sintim HO; Chemistry Department, Institute for Drug Discovery, Purdue University, West Lafayette, Indiana 47907, United States.; Purdue Institute of Inflammation, Immunology, and Infectious Disease, West Lafayette, Indiana 47907, United States.

Publikováno v: Journal of medicinal chemistry [J Med Chem] 2020 Oct 22; Vol. 63 (20), pp. 11934-11944. Date of Electronic Publication: 2020 Oct 06.

Lipoteichoic Acid Biosynthesis Inhibitors as Potent Inhibitors of S. aureus and E. faecalis Growth and Biofilm Formation.

Autor: Naclerio GA; Chemistry Department, Institute for Drug Discovery, Purdue University, West Lafayette, IN 47907, USA., Onyedibe KI; Chemistry Department, Institute for Drug Discovery, Purdue University, West Lafayette, IN 47907, USA.; Purdue Institute for Inflammation, Immunology, and Infectious Diseases, West Lafayette, IN 47907, USA., Sintim HO; Chemistry Department, Institute for Drug Discovery, Purdue University, West Lafayette, IN 47907, USA.; Purdue Institute for Inflammation, Immunology, and Infectious Diseases, West Lafayette, IN 47907, USA.

Publikováno v: Molecules (Basel, Switzerland) [Molecules] 2020 May 12; Vol. 25 (10). Date of Electronic Publication: 2020 May 12.

Potently inhibiting cancer cell migration with novel 3H-pyrazolo[4,3-f]quinoline boronic acid ROCK inhibitors.

Autor: Dayal N; Department of Chemistry, Purdue University, 560 Oval Drive, West Lafayette, IN, 47907, USA., Mikek CG; Department of Chemistry, Purdue University, 560 Oval Drive, West Lafayette, IN, 47907, USA., Hernandez D; Department of Chemistry, Purdue University, 560 Oval Drive, West Lafayette, IN, 47907, USA., Naclerio GA; Department of Chemistry, Purdue University, 560 Oval Drive, West Lafayette, IN, 47907, USA., Yin Chu EF; Department of Chemistry, Purdue University, 560 Oval Drive, West Lafayette, IN, 47907, USA., Carter-Cooper BA; Translational Core Laboratory, University of Maryland Greenebaum Cancer Center, 655 W Baltimore Street, Baltimore, MD, 21201, USA., Lapidus RG; Translational Core Laboratory, University of Maryland Greenebaum Cancer Center, 655 W Baltimore Street, Baltimore, MD, 21201, USA., Sintim HO; Department of Chemistry, Purdue University, 560 Oval Drive, West Lafayette, IN, 47907, USA; Institute for Drug Discovery, Purdue University, 720 Clinic Drive, West Lafayette, IN, 47907, USA; Purdue Institute of Inflammation and Infectious Diseases, Purdue University, West Lafayette, IN, 47907, USA. Electronic address: hsintim@purdue.edu.

Publikováno v: European journal of medicinal chemistry [Eur J Med Chem] 2019 Oct 15; Vol. 180, pp. 449-456. Date of Electronic Publication: 2019 Jun 29.