Mechanistic Studies and In Vivo Efficacy of an Oxadiazole-Containing Antibiotic.

Autor: Naclerio GA; Chemistry Department, Institute for Drug Discovery, Purdue University, West Lafayette, Indiana 47907, United States., Abutaleb NS; Department of Biomedical Sciences and Pathobiology, Virginia-Maryland College of Veterinary Medicine, Virginia Polytechnic Institute and State University, Blacksburg, Virginia 24060, United States.; Department of Comparative Pathobiology, College of Veterinary Medicine, Purdue University, West Lafayette, Indiana 47907, United States., Onyedibe KI; Chemistry Department, Institute for Drug Discovery, Purdue University, West Lafayette, Indiana 47907, United States.; Purdue Institute of Inflammation, Immunology, and Infectious Disease, Purdue University, West Lafayette, Indiana 47907, United States., Karanja C; Chemistry Department, Institute for Drug Discovery, Purdue University, West Lafayette, Indiana 47907, United States., Eldesouky HE; Department of Biomedical Sciences and Pathobiology, Virginia-Maryland College of Veterinary Medicine, Virginia Polytechnic Institute and State University, Blacksburg, Virginia 24060, United States.; Department of Comparative Pathobiology, College of Veterinary Medicine, Purdue University, West Lafayette, Indiana 47907, United States., Liang HW; Department of Biomedical Sciences and Pathobiology, Virginia-Maryland College of Veterinary Medicine, Virginia Polytechnic Institute and State University, Blacksburg, Virginia 24060, United States., Dieterly A; Department of Comparative Pathobiology, College of Veterinary Medicine, Purdue University, West Lafayette, Indiana 47907, United States., Aryal UK; Department of Comparative Pathobiology, College of Veterinary Medicine, Purdue University, West Lafayette, Indiana 47907, United States.; Purdue Proteomics Facility, Bindley Bioscience Center, Purdue University, West Lafayette, Indiana 47907, United States., Lyle T; Department of Comparative Pathobiology, College of Veterinary Medicine, Purdue University, West Lafayette, Indiana 47907, United States.; Center for Comparative Translational Research, Purdue University, West Lafayette, Indiana 47907, United States., Seleem MN; Department of Biomedical Sciences and Pathobiology, Virginia-Maryland College of Veterinary Medicine, Virginia Polytechnic Institute and State University, Blacksburg, Virginia 24060, United States.; Department of Comparative Pathobiology, College of Veterinary Medicine, Purdue University, West Lafayette, Indiana 47907, United States.; Center for Emerging, Zoonotic and Arthropod-borne Pathogens, Virginia Polytechnic Institute and State University, Blacksburg, Virginia 24061, United States., Sintim HO; Chemistry Department, Institute for Drug Discovery, Purdue University, West Lafayette, Indiana 47907, United States.; Purdue Institute of Inflammation, Immunology, and Infectious Disease, Purdue University, West Lafayette, Indiana 47907, United States.

Publikováno v: Journal of medicinal chemistry [J Med Chem] 2022 May 12; Vol. 65 (9), pp. 6612-6630. Date of Electronic Publication: 2022 Apr 28.

Starving Bacteria of Iron: A Potential Strategy to Disperse Bacterial Biofilms.

Autor: Naclerio GA; Chemistry Department, Institute for Drug Discovery, Purdue University, West Lafayette, Indiana 47907, United States., Sintim HO; Chemistry Department, Institute for Drug Discovery, Purdue University, West Lafayette, Indiana 47907, United States.; Purdue Institute for Inflammation, Immunology, and Infectious Diseases, Purdue University, West Lafayette, Indiana 47907, United States.

Publikováno v: Journal of medicinal chemistry [J Med Chem] 2021 Jun 10; Vol. 64 (11), pp. 7272-7274. Date of Electronic Publication: 2021 May 14.

N -(1,3,4-Oxadiazol-2-yl)Benzamides as Antibacterial Agents against Neisseria gonorrhoeae .

Autor: Naclerio GA; Chemistry Department, Institute for Drug Discovery, Purdue University, West Lafayette, IN 47907, USA., Abutaleb NS; Department of Comparative Pathobiology, Purdue University College of Veterinary Medicine, West Lafayette, IN 47907, USA., Alhashimi M; Department of Comparative Pathobiology, Purdue University College of Veterinary Medicine, West Lafayette, IN 47907, USA., Seleem MN; Department of Comparative Pathobiology, Purdue University College of Veterinary Medicine, West Lafayette, IN 47907, USA.; Department of Biomedical Sciences and Pathobiology, Virginia-Maryland College of Veterinary Medicine, Virginia Polytechnic Institute and State University, Blacksburg, VA 24060, USA.; Purdue Institute of Inflammation, Immunology, and Infectious Disease, West Lafayette, IN 47907, USA., Sintim HO; Chemistry Department, Institute for Drug Discovery, Purdue University, West Lafayette, IN 47907, USA.; Purdue Institute of Inflammation, Immunology, and Infectious Disease, West Lafayette, IN 47907, USA.

Publikováno v: International journal of molecular sciences [Int J Mol Sci] 2021 Feb 28; Vol. 22 (5). Date of Electronic Publication: 2021 Feb 28.

Multiple ways to kill bacteria via inhibiting novel cell wall or membrane targets.

Autor: Naclerio GA; Institute for Drug Discovery, Purdue University, West Lafayette, IN 47907, USA.; Department of Chemistry, Purdue University, West Lafayette, IN 47907, USA., Sintim HO; Institute for Drug Discovery, Purdue University, West Lafayette, IN 47907, USA.; Department of Chemistry, Purdue University, West Lafayette, IN 47907, USA.; Purdue Institute of Inflammation, Immunology & Infectious Disease, Purdue University, West Lafayette, IN 47907, USA.

Publikováno v: Future medicinal chemistry [Future Med Chem] 2020 Jul; Vol. 12 (13), pp. 1253-1279. Date of Electronic Publication: 2020 Jun 15.

Synergistic potential of Leu10-teixobactin and cefepime against multidrug-resistant Staphylococcus aureus.

Autor: Koh, Augustine Jing Jie^1,2,3 (AUTHOR), Hussein, Maytham^1,2 (AUTHOR), Thombare, Varsha² (AUTHOR), Crawford, Simon⁴ (AUTHOR), Li, Jian³ (AUTHOR) jian.li@monash.edu, Velkov, Tony^1,2 (AUTHOR) tony.velkov@monash.edu

Publikováno v: BMC Microbiology. 10/29/2024, Vol. 24 Issue 1, p1-11. 11p.