Datasets, processing and refinement details for Mtb-AnPRT: inhibitor structures with various space groups

Autor: Genevieve L. Evans, Daniel P. Furkert, Nacim Abermil, Preeti Kundu, Katrina M. de Lange, Emily J. Parker, Margaret A. Brimble, Edward N. Baker, J. Shaun Lott

Publikováno v: Data in Brief, Vol 15, Iss , Pp 1019-1029 (2017)

There are twenty-five published structures of Mycobacterium tuberculosis anthranilate phosphoribosyltransferase (Mtb-AnPRT) that use the same crystallization protocol. The structures include protein complexed with natural and alternative substrates,

Externí odkaz: https://doaj.org/article/5c6539f806014fd3a63a51b4a3d201bc

Anthranilate phosphoribosyltransferase: Binding determinants for 5'-phospho-alpha-d-ribosyl-1'-pyrophosphate (PRPP) and the implications for inhibitor design

Autor: Daniel P. Furkert, Nacim Abermil, J. Shaun Lott, Emily J. Parker, Genevieve L. Evans, Katrina M. de Lange, Preeti Kundu, Edward N. Baker, Margaret A. Brimble

Publikováno v: Biochimica et biophysica acta. Proteins and proteomics. 1866(2)

Phosphoribosyltransferases (PRTs) bind 5'-phospho-α-d-ribosyl-1'-pyrophosphate (PRPP) and transfer its phosphoribosyl group (PRib) to specific nucleophiles. Anthranilate PRT (AnPRT) is a promiscuous PRT that can phosphoribosylate both anthranilate a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c572dda4e429a98e6e708760a934c9b7
https://pubmed.ncbi.nlm.nih.gov/28844746

ChemInform Abstract: Invertible Enantioselectivity in 6′-Deoxy-6′-acylamino-β-isocupreidine-Catalyzed Asymmetric Aza-Morita-Baylis-Hillman Reaction: Key Role of Achiral Additive

Autor: Géraldine Masson, Jieping Zhu, Nacim Abermil

Publikováno v: ChemInform. 41

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::d8a8e6e2b7bb5ad0cdace942460cfc20
https://doi.org/10.1002/chin.201009079

Invertible enantioselectivity in 6'-deoxy-6'-acylamino-beta-isocupreidine-catalyzed asymmetric aza-Morita-Baylis-Hillman reaction: key role of achiral additive

Autor: Jieping Zhu, Nacim Abermil, Géraldine Masson

Publikováno v: Organic Letters
Organic Letters, American Chemical Society, 2009, 11 (20), pp.4648-51. ⟨10.1021/ol901920s⟩

International audience; The beta-ICD (1a) or beta-ICD-amide (1e)-catalyzed aza-Morita-Baylis-Hillman reaction between N-sulfonylimines 3 and alkyl vinyl ketones 4 produced the (R)-enriched adducts 5. By adding a catalytic amount of beta-naphthol (2a)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f2e2c5902c77520fb666436d274d7a9c
https://hal.archives-ouvertes.fr/hal-00428728

Highly enantioselective aza Morita-Baylis-Hillman reaction catalyzed by bifunctional beta-isocupreidine derivatives

Autor: Nacim Abermil, Jieping Zhu, Géraldine Masson

Publikováno v: Journal of the American Chemical Society
Journal of the American Chemical Society, 2008, 130 (38), pp.12596-7. ⟨10.1021/ja805122j⟩
Journal of the American Chemical Society, American Chemical Society, 2008, 130 (38), pp.12596-7. ⟨10.1021/ja805122j⟩

International audience; The aza-MBH reaction of imines 1 and beta-naphthyl acrylate 2 in the presence of C-6' modified beta-isocupreidine derivative 1c (0.1 equiv) and beta-naphthol 5 (0.1 equiv) afforded the corresponding (3S)-aza-MBH adducts 4 in h

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0fcdfe1a1f25bf6bca931dbfcbd5f975
https://hal.science/hal-00337288