Zobrazeno 1 - 10
of 37
pro vyhledávání: '"Nachwa Jarkas"'
Autor:
Nachwa Jarkas, David M. Schuster, Jonathan McConathy, Weiping Yu, Wonewoo Seo, Mark M. Goodman
Publikováno v:
Medicinal Research Reviews. 32:868-905
Radiohalogenated α-amino acids are a diverse and useful class tumor imaging agents suitable for positron emission tomography and single photon emission computed tomography. These tracers target the increased rates of amino acid transport exhibited b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e4e7ec6a856b19bfbbc73e78edac7cd2
https://doi.org/10.1002/med.20250
https://doi.org/10.1002/med.20250
Autor:
J D Bremner, Clinton D. Kilts, Nachwa Jarkas, David Purselle, Charles B. Nemeroff, Vernon M. Camp, Mark M. Goodman, Jonathon A. Nye, John R. Votaw
Publikováno v:
Journal of Nuclear Medicine. 49:2018-2025
The novel PET radioligand 11C-N,N-dimethyl-2-(2′-amino-4′-hydroxymethylphenylthio)benzylamine (11C-HOMADAM) binds with high affinity and selectively to the serotonin transporter (SERT). The purpose of this study was to develop a reliable kinetic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8682bf99d59abe30eb2fd15da2540143
https://doi.org/10.2967/jnumed.108.054262
https://doi.org/10.2967/jnumed.108.054262
Autor:
Michael J. Owens, Charles B. Nemeroff, Jeffrey S. Stehouwer, Nachwa Jarkas, Clinton D. Kilts, Fanxing Zeng, Mark M. Goodman, Ronald J. Voll
Publikováno v:
Bioorganic & Medicinal Chemistry. 16:783-793
Six new (S,S)-enantiomers of reboxetine derivatives were synthesized and their binding affinities were determined via competition binding assays in cells expressing the human norepinephrine transporter (NET), serotonin transporter (SERT) or dopamine
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ef974358ddf53d1cb1f595a219f56ca2
https://doi.org/10.1016/j.bmc.2007.10.025
https://doi.org/10.1016/j.bmc.2007.10.025
Autor:
Mike Owens, Nachwa Jarkas, Ronald J. Voll, John R. Votaw, Mark M. Goodman, Lawrence E. Williams
Publikováno v:
Journal of Medicinal Chemistry. 51:271-281
N, N-dimethyl-2-(2'-amino-4'-hydroxymethylphenylthio)benzylamine (38), substituted on ring A, was reported to display high binding affinity and selectivity to the human brain serotonin transporter (SERT). In an attempt to explore the potential of com
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4b45bb961cca7673c4dfd3a5d2139ab8
https://doi.org/10.1021/jm0707929
https://doi.org/10.1021/jm0707929
Autor:
Eric Brenner, Julie K. Staley, Mark M. Goodman, Colin N. Haile, Ross J. Baldessarini, Frank I. Tarazi, Nachwa Jarkas, Ronald M. Baldwin, Gilles Tamagnan, David Alagille, Andrei O. Koren, John Seibyl, Michelle Early
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 17:533-537
A series of reboxetine analogs was synthesized and evaluated for in vitro binding as racemic mixtures. The best candidate (INER) was synthesized as the optically pure (S,S) enantiomer, labeled with iodine-123 and its in vivo binding determined by SPE
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::327cd69e02339f4541b13632c84dae88
https://doi.org/10.1016/j.bmcl.2006.10.018
https://doi.org/10.1016/j.bmcl.2006.10.018
Autor:
Nachwa Jarkas, Eugene J. Malveaux, Michael J. Owens, Vernon M. Camp, Leonard L. Howell, Ronald Voll, Jeffrey S. Stehouwer, Mark M. Goodman, Larry A Williams, John Votaw, Fanxing Zeng
Publikováno v:
Journal of Medicinal Chemistry. 49:6760-6767
2beta-carbomethoxy-3beta-(3'-((Z)-2-iodoethenyl)phenyl)nortropane (mZIENT, 1) and 2beta-carbomethoxy-3beta-(3'-((Z)-2-bromoethenyl)phenyl)nortropane (mZBrENT, 2) were synthesized and evaluated for binding to the human serotonin, dopamine, and norepin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8262054a723f8ab7c26918a6601a8a6f
https://doi.org/10.1021/jm060641q
https://doi.org/10.1021/jm060641q
Autor:
Nachwa Jarkas, John R. Votaw, Ronald J. Voll, Mark M. Goodman, Laurent Martarello, Fanxing Zeng, Jeffrey S. Stehouwer, Gilles Tamagnan, Lawrence E. Williams, Christophe Plisson
Publikováno v:
Journal of Medicinal Chemistry. 48:7080-7083
2beta-Carbomethoxy-3beta-(4'-(3-furyl)phenyl)nortropane (1) was synthesized along with the N-methyl (2), N-fluoroethyl (3), N-fluoropropyl (4), and N-fluorobutyl (5) derivatives. The binding affinity for each compound to the human serotonin, dopamine
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::df0a1cbaaa3c144735192c07d7ba08ff
https://doi.org/10.1021/jm0504095
https://doi.org/10.1021/jm0504095
Autor:
Robin R. Goodman, John R. Votaw, Vernon M. Camp, Mark M. Goodman, Eugene Malveaux, Lawrence E. Williams, Jonathan McConathy, Nachwa Jarkas, Ronald J. Voll, Clinton D. Kilts
Publikováno v:
Nuclear Medicine and Biology. 32:75-86
[ 11 C] N , N -Dimethyl-2-(2′-amino-4′-ethylphenylthio)benzylamine ([ 11 C]EADAM) was synthesized in the development of a serotonin transporter (SERT) imaging ligand for positron emission tomography (PET). The methods of ligand synthesis, results
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c43f38814e2d3fd908674f70d2774630
https://doi.org/10.1016/j.nucmedbio.2004.07.001
https://doi.org/10.1016/j.nucmedbio.2004.07.001
Publikováno v:
Phosphorus, Sulfur, and Silicon and the Related Elements. 136:353-356
Pyridocarbazole moiety is found for example in alkaloids from the ellipticine 1 series and indolocarbazole in tjipanozole 2 and staurosporine 3.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8eafbfded843209b74dd18f43bfcb0f7
https://doi.org/10.1080/10426509808545960
https://doi.org/10.1080/10426509808545960
Autor:
Jonathan, McConathy, Weiping, Yu, Nachwa, Jarkas, Wonewoo, Seo, David M, Schuster, Mark M, Goodman
Publikováno v:
Medicinal research reviews. 32(4)
Radiohalogenated α-amino acids are a diverse and useful class tumor imaging agents suitable for positron emission tomography and single photon emission computed tomography. These tracers target the increased rates of amino acid transport exhibited b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::8466643477196769617697eb332a7632
https://pubmed.ncbi.nlm.nih.gov/21793016
https://pubmed.ncbi.nlm.nih.gov/21793016