Zobrazeno 1 - 10
of 39
pro vyhledávání: '"Nacho Molina"'
Autor:
Andrea Riba, Attila Oravecz, Matej Durik, Sara Jiménez, Violaine Alunni, Marie Cerciat, Matthieu Jung, Céline Keime, William M. Keyes, Nacho Molina
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-13 (2022)
Single-cell RNA-sequencing technology gives access to cell cycle dynamics without externally perturbing the cell. Here the authors present DeepCycle,a robust deep learning method to infer the cell cycle state in single cells from scRNA-seq data.
Externí odkaz:
https://doaj.org/article/341a0ba6bc3645fd9825106ec997e38b
Autor:
Guilherme M. Oliveira, Attila Oravecz, Dominique Kobi, Manon Maroquenne, Kerstin Bystricky, Tom Sexton, Nacho Molina
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-11 (2021)
Although much effort has been devoted to determine the 3D structure of chromatin, there is a need for new experimental and computational methods. Here the authors present GP-FBM to extract chromatin diffusion parameters with high precision and apply
Externí odkaz:
https://doaj.org/article/eba51ec0a96e44f5b8ba7cece22b98b4
Publikováno v:
PLoS Computational Biology, Vol 17, Iss 10, p e1009354 (2021)
Proliferating cells experience a global reduction of transcription during mitosis, yet their cell identity is maintained and regulatory information is propagated from mother to daughter cells. Mitotic bookmarking by transcription factors has been pro
Externí odkaz:
https://doaj.org/article/13b341c9bdc9417fbf67f99be2e4abaf
Autor:
Julie Piccand, Constance Vagne, Florence Blot, Aline Meunier, Anthony Beucher, Perrine Strasser, Mari L. Lund, Sabitri Ghimire, Laure Nivlet, Céline Lapp, Natalia Petersen, Maja S. Engelstoft, Christelle Thibault-Carpentier, Céline Keime, Sara Jimenez Correa, Valérie Schreiber, Nacho Molina, Thue W. Schwartz, Adèle De Arcangelis, Gérard Gradwohl
Publikováno v:
Molecular Metabolism, Vol 29, Iss , Pp 24-39 (2019)
Objective: Enteroendocrine cells (EECs) of the gastro-intestinal tract sense gut luminal factors and release peptide hormones or serotonin (5-HT) to coordinate energy uptake and storage. Our goal is to decipher the gene regulatory networks controllin
Externí odkaz:
https://doaj.org/article/ae5bc94129d345d5a7f7ab5313070cd2
Autor:
Samuel Zambrano, Alessia Loffreda, Elena Carelli, Giacomo Stefanelli, Federica Colombo, Edouard Bertrand, Carlo Tacchetti, Alessandra Agresti, Marco E. Bianchi, Nacho Molina, Davide Mazza
Publikováno v:
iScience, Vol 23, Iss 9, Pp 101529- (2020)
Summary: Nuclear factor (NF)-κB controls the transcriptional response to inflammatory signals by translocating into the nucleus, but we lack a single-cell characterization of the resulting transcription dynamics. Here we show that upon tumor necrosi
Externí odkaz:
https://doaj.org/article/6e8e669d5ae54817b3343b02e8876ff9
Publikováno v:
eLife, Vol 7 (2018)
Coordination of cell growth with division is essential for proper cell function. In budding yeast, although some molecular mechanisms responsible for cell size control during G1 have been elucidated, the mechanism by which cell size homeostasis is es
Externí odkaz:
https://doaj.org/article/5e9890cd8f064953a5436af22be665a4
Publikováno v:
Molecular Systems Biology, Vol 11, Iss 7, Pp 1-15 (2015)
Abstract Mammalian transcription occurs stochastically in short bursts interspersed by silent intervals showing a refractory period. However, the underlying processes and consequences on fluctuations in gene products are poorly understood. Here, we u
Externí odkaz:
https://doaj.org/article/c45ca63a29b840e38a4c119df92bb6e6
Autor:
Angeliki Platania, Cathie Erb, Mariano Barbieri, Bastien Molcrette, Erwan Grandgirard, Marit AC de Kort, Karen Meaburn, Tiegh Taylor, Virlana M Shchuka, Silvia Kocanova, Guilherme Monteiro Oliveira, Jennifer A Mitchell, Evi Soutoglou, Tineke L Lenstra, Nacho Molina, Argyris Papantonis, Kerstin Bystricky, Tom Sexton
SUMMARYThe spatiotemporal configuration of genes with distal regulatory elements, and the impact of chromatin mobility on transcription, remain unclear. Loop extrusion is an attractive model for bringing genetic elements together, but how this functi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3d54da95b9476e7cf0d9e77f302b60e3
https://doi.org/10.2139/ssrn.4428770
https://doi.org/10.2139/ssrn.4428770
Modulation of gene expression during differentiation by transcription factors promotes cell diversity. Despite their role in cell fate decisions, no experimental assays estimate their regulatory activity in a high-throughput manner and at the single-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::08bb7e9b966a3566237ae2e37c749290
https://doi.org/10.1101/2022.04.01.486696
https://doi.org/10.1101/2022.04.01.486696
Publikováno v:
PLoS Computational Biology, Vol 17, Iss 10, p e1009354 (2021)
PLoS Computational Biology
PLoS Computational Biology, 2021, 17 (10), ⟨10.1371/journal.pcbi.1009354⟩
PLoS Computational Biology
PLoS Computational Biology, 2021, 17 (10), ⟨10.1371/journal.pcbi.1009354⟩
Proliferating cells experience a global reduction of transcription during mitosis, yet their cell identity is maintained and regulatory information is propagated from mother to daughter cells. Mitotic bookmarking by transcription factors has been pro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3177053a823c1cdb094fbb40c77e54b9
https://doaj.org/article/13b341c9bdc9417fbf67f99be2e4abaf
https://doaj.org/article/13b341c9bdc9417fbf67f99be2e4abaf