ChemInform Abstract: Novel, Potent, and Selective 5-HT3 Receptor Antagonists Based on the Arylpiperazine Skeleton: Synthesis, Structure, Biological Activity, and Comparative Molecular Field Analysis Studies

Autor: Maurizio Anzini, Nacera Merahi, Gianluca Giorgi, Andrea Cappelli, Tiziana Mennini, Thierry Langer, Salvatore Vomero, Julia Pinto, Alfredo Cagnotto, M. Skorupska, M. Hamon, Boris M. Emerit

Publikováno v: ChemInform. 26

Synthesis and pharmacological evaluation of a series of condensed quinoline derivatives bearing a basic nitrogen on piperazine or [(dimethylamino)ethyl]thio moieties attached at the 2-position of the quinoline nucleus are described. 5-HT receptor bin

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::caf41f55c6a2e9471c34fc31f40f0d03
https://doi.org/10.1002/chin.199545191

Baroreceptor reflex inhibition induced by the stimulation of serotonin3 receptors in the nucleus tractus solitarius of the rat

Autor: Raul Laguzzi, Hakan S. Orer, Nacera Merahi, A. M. Laporte, Henri Gozlan, Michel Hamon

Publikováno v: Neuroscience. 46:91-100

Previous studies suggested that in the nucleus tractus solitarius, cardiovascular responses to serotonin may involve the simultaneous activation of more than one receptor subtype. In the present study, the cardiovascular effects of the local applicat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::310ae6df84456f55b1ece73d37f64fce
https://doi.org/10.1016/0306-4522(92)90011-p

Novel, potent, and selective 5-HT3 receptor antagonists based on the arylpiperazine skeleton: synthesis, structure, biological activity, and comparative molecular field analysis studies

Autor: Julia Pinto, Salvatore Vomero, Gianluca Giorgi, M. Skorupska, Alfredo Cagnotto, Thierry Langer, Boris M. Emerit, Andrea Cappelli, M. Hamon, Tiziana Mennini, Maurizio Anzini, Nacera Merahi

Publikováno v: Journal of medicinal chemistry. 38(14)

Synthesis and pharmacological evaluation of a series of condensed quinoline derivatives bearing a basic nitrogen on piperazine or [(dimethylamino)ethyl]thio moieties attached at the 2-position of the quinoline nucleus are described. 5-HT receptor bin

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1ddf22143407faec33f743464a1bb029
https://pubmed.ncbi.nlm.nih.gov/7629808

Sleep changes induced by the local application of 5,7-dihydroxytryptamine into the nodose ganglia and aortic denervation in the rat

Autor: Henri Gozlan, Hakan S. Orer, Raul Laguzzi, Anne Nosjean, Nacera Merahi

Publikováno v: Pflügers Archiv European Journal of Physiology
Pflügers Archiv European Journal of Physiology, Springer Verlag, 1991, 419 (1), pp.21-24. ⟨10.1007/BF00373742⟩
Pflügers Archiv European Journal of Physiology, 1991, 419 (1), pp.21-24. ⟨10.1007/BF00373742⟩

International audience; The effects of a bilateral microinjection of 5,7-dihydroxytryptamine (5,7-DHT) into the nodose ganglia and aortic denervation on the daily amounts of sleep/wake states were studied in rats. Both lesions produced an increase in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7ba57a3e3d686d7099edc9feaf146299
https://hal.archives-ouvertes.fr/hal-03301167

Serotonergic projections from the nodose ganglia to the nucleus tractus solitarius: an immunohistochemical and double labeling study in the rat

Autor: Anne Nosjean, Nacera Merahi, Jean-Jacques Puizillout, Catherine Buisseret-Delmas, Raul Laguzzi, Claude Compoint, Hakan S. Orer

Publikováno v: Neuroscience Letters
Neuroscience Letters, Elsevier, 1990, 114 (1), pp.22-26. ⟨10.1016/0304-3940(90)90422-6⟩
Neuroscience Letters, 1990, 114 (1), pp.22-26. ⟨10.1016/0304-3940(90)90422-6⟩

International audience; Possible projections of serotonin (5-HT)-immunoreactive neurons in the nodose ganglia (NG) to the nucleus tractus solitarius (NTS) were investigated in the rat using a double labeling method combining retrograde transport and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f352fbde9101085da4cae15b579e78d7
https://pubmed.ncbi.nlm.nih.gov/1696365