Zobrazeno 1 - 10
of 36
pro vyhledávání: '"Nacer Abbas"'
Autor:
Wen-Jie Gu, Olga Corti, Francisco Araujo, Cornelia Hampe, Sandrine Jacquier, Christoph B Lücking, Nacer Abbas, Charles Duyckaerts, Thomas Rooney, Laurent Pradier, Merle Ruberg, Alexis Brice
Publikováno v:
Neurobiology of Disease, Vol 14, Iss 3, Pp 357-364 (2003)
Mutations in the parkin gene are responsible for autosomal recessive parkinsonism. The disease-linked missense mutations are highly concentrated in the RING–IBR–RING domains of Parkin. In this study, we investigated the consequences of several mi
Externí odkaz:
https://doaj.org/article/e384570854344d029f9efd7f387cef11
Autor:
Andreas Hartmann, Annick Mouatt-Prigent, Miquel Vila, Nacer Abbas, Céline Perier, Baptiste A. Faucheux, Sheela Vyas, Etienne C. Hirsch
Publikováno v:
Neurobiology of Disease, Vol 10, Iss 1, Pp 28-32 (2002)
In the present study, we tried to clarify the potentially protective role of Bcl-xL, an anti-apoptotic member of the Bcl-2 family of proteins, in Parkinson's disease (PD). Using in situ hybridization on human postmortem mesencephalon sections, we sho
Externí odkaz:
https://doaj.org/article/8eb3dc41fa2241649e9029dd60b397e6
Autor:
Gilles David, Paola Giunti, Géraldine Cancel, Nacer Abbas, Alexandra Durr, Merle Ruberg, Charles Duyckaerts, Monica Holmberg, Jean-Louis Mandel, Giovanni Stevanin, Alexis Brice
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3f724e43e176079676bf05ee47285853
https://doi.org/10.1201/9781003076933-10
https://doi.org/10.1201/9781003076933-10
Autor:
Nacer Abbas, Patrice Denefle, Jeremy Pratt, Maria Angeles Mena, Gunter Tremp, Thomas Rooney, Eva Gallego, Marina P. Sánchez, Gwénnäelle Ret, Francisco Araujo, Chantal Joubert, Justo García de Yébenes, Pablo Ibanez, Alexis Brice, Rosa M. Solano, Olga Corti, Charles Cohen-Salmon, Jean Michel Itier, Laurent Pradier, Michel Laville, Magali Periquet, Santiago Canals, Alba Serrano, María José Casarejos, Julia Negroni, Georg Andrees Bohme, Jesus Benavides
Publikováno v:
Human Molecular Genetics. 12:2277-2291
Mutations of the parkin gene are the most frequent cause of early onset autosomal recessive parkinsonism (EO-AR). Here we show that inactivation of the parkin gene in mice results in motor and cognitive deficits, inhibition of amphetamine-induced dop
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::08af4b7c2aabd7f608f69e18482c3683
https://doi.org/10.1093/hmg/ddg239
https://doi.org/10.1093/hmg/ddg239
Parkin prevents mitochondrial swelling and cytochrome c release in mitochondria-dependent cell death
Autor:
Cornelia Hampe, Alexis Brice, Christoph B. Lücking, Marie-Paule Muriel, Wen-Jie Gu, Thomas Rooney, Nacer Abbas, Merle Ruberg, Frédéric Darios, Olga Corti, Etienne C. Hirsch
Publikováno v:
Human Molecular Genetics. 12:517-526
Parkin gene mutations have been implicated in autosomal-recessive early-onset parkinsonism and lead to specific degeneration of dopaminergic neurons in midbrain. To investigate the role of Parkin in neuronal cell death, we overproduced this protein i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0e5182a85cae5de42cecea7c64121e54
https://doi.org/10.1093/hmg/ddg044
https://doi.org/10.1093/hmg/ddg044
Autor:
Céline Périer, Andreas Hartmann, Etienne C. Hirsch, Nacer Abbas, Sheela Vyas, Baptiste Faucheux, A. Mouatt-Prigent, Miquel Vila
Publikováno v:
Neurobiology of Disease, Vol 10, Iss 1, Pp 28-32 (2002)
In the present study, we tried to clarify the potentially protective role of Bcl-xL, an anti-apoptotic member of the Bcl-2 family of proteins, in Parkinson's disease (PD). Using in situ hybridization on human postmortem mesencephalon sections, we sho
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8ca93920abf3c4e257b17b3fc68d9070
http://www.sciencedirect.com/science/article/pii/S0969996102904948
http://www.sciencedirect.com/science/article/pii/S0969996102904948
Autor:
Nacer Abbas, André Parent, Martin Zarate Lagunes, Etienne C. Hirsch, Yves Agid, Laurent Pradier, Rita Raisman-Vozari, Wen-Jie Gu, Alexis Brice, Georg Andrees Bohme
Publikováno v:
Journal of Neurochemistry. 74:1773-1776
The rat parkin cDNA sequence was characterized after screening a rat hypothalamus cDNA library with a 32P-labeled probe containing the entire open reading frame of the human parkin cDNA. This sequence encompasses 1,576 bp and contains a single open r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5a5258bf8ab9848bf5b5c703f31f14ff
https://doi.org/10.1046/j.1471-4159.2000.0741773.x
https://doi.org/10.1046/j.1471-4159.2000.0741773.x
Autor:
Roberto Marconi, Bouley S, Emmanuel Broussolle, De Michele G, Alexis Brice, Alessandro Filla, Ben A. Oostra, Alexandra Durr, Patrice Denefle, Biswadjiet S. Harhangi, Nicholas W. Wood, C. B. Lücking, Yves Agid, Edito Fabrizio, Bonifati, Giuseppe Meco, Laurent Pradier, Vaughan, Nacer Abbas, Thomas Gasser, Ricard S, Georg Andrees Bohme, Christine Brefel-Courbon
Publikováno v:
Human Molecular Genetics, 8(4), 567-574. Oxford University Press
Scopus-Elsevier
Scopus-Elsevier
Autosomal recessive juvenile parkinsonism (AR-JP, PARK2; OMIM 602544), one of the monogenic forms of Parkinson's disease (PD), was initially described in Japan. It is characterized by early onset (before age 40), marked response to levodopa treatment
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e38739f37c53c53b1c35d4aa20999aa2
https://doi.org/10.1093/hmg/8.4.567
https://doi.org/10.1093/hmg/8.4.567
Autor:
Thomas De Broucker, Giuseppe De Michele, Vincenzo Bonifati, Nacer Abbas, Emmanuel Broussolle, Alexis Brice, Soraya Medjbeur, Johann Tassin, Anne-Marie Bonnet, Marie Vidailhet, Yves Agid, Roberto Marconi, Giuseppe Meco, Alexandra Durr, Michele De Mari, Pierre Pollak, A. Filla
Publikováno v:
The American Journal of Human Genetics. 63(1):88-94
SummaryThe gene for autosomal recessive juvenile Parkinsonism (AR-JP) recently has been mapped to chromosome 6q25.2–27 in Japanese families. We have tested one Algerian and 10 European multiplex families with early-onset Parkinson disease for linka
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::79eec05458ffbe1c23a55c410e767d48
Autor:
Géraldine Cancel, Fayçal Hentati, Monica Holmberg, D. Grid, Mohamed Yahyaoui, Yves Agid, Anne-Sophie Lebre, T. Chkili, Alexis Brice, Myriem Abada-Bendib, Gilles David, Giovanni Stevanin, Samir Belal, Ali Benomar, Nacer Abbas, Alexandra Durr
Publikováno v:
Human Molecular Genetics. 7:165-170
Spinocerebellar ataxia 7 (SCA7) is caused by the expansion of an unstable CAG repeat in the first exon of the SCA7 gene. We have analyzed the SCA7 mutation in 19 families and one isolated case of various geographical origins, presenting with autosoma
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1b1269be9d51618a8cde3b66716eff10
https://doi.org/10.1093/hmg/7.2.165
https://doi.org/10.1093/hmg/7.2.165