Immunization with Low Doses of Recombinant Postfusion or Prefusion Respiratory Syncytial Virus F Primes for Vaccine-Enhanced Disease in the Cotton Rat Model Independently of the Presence of a Th1-Biasing (GLA-SE) or Th2-Biasing (Alum) Adjuvant.

Autor: Schneider-Ohrum K; Department of Infectious Disease/Vaccines, Medimmune, Gaithersburg, Maryland, USA., Cayatte C; Department of Infectious Disease/Vaccines, Medimmune, Gaithersburg, Maryland, USA cayattec@medimmune.com., Bennett AS; Department of Infectious Disease/Vaccines, Medimmune, Gaithersburg, Maryland, USA., Rajani GM; Department of Infectious Disease/Vaccines, Medimmune, Gaithersburg, Maryland, USA., McTamney P; Department of Infectious Disease/Vaccines, Medimmune, Gaithersburg, Maryland, USA., Nacel K; Department of Laboratory Animal Resources, Medimmune, Gaithersburg, Maryland, USA., Hostetler L; Department of Laboratory Animal Resources, Medimmune, Gaithersburg, Maryland, USA., Cheng L; Pathology Department, Medimmune, Gaithersburg, Maryland, USA., Ren K; Department of Infectious Disease/Vaccines, Medimmune, Gaithersburg, Maryland, USA., O'Day T; Department of Statistical Sciences, Medimmune, Gaithersburg, Maryland, USA., Prince GA; Independent Researcher, Potomac, Maryland, USA., McCarthy MP; Department of Infectious Disease/Vaccines, Medimmune, Gaithersburg, Maryland, USA.

Publikováno v: Journal of virology [J Virol] 2017 Mar 29; Vol. 91 (8). Date of Electronic Publication: 2017 Mar 29 (Print Publication: 2017).

Development of Respiratory Syncytial Virus Vaccine Candidates for the Elderly.

Autor: Blanco, Jorge C. G.¹ (AUTHOR) j.blanco@sigmovir.com, Cullen, Lori M.² (AUTHOR), Kamali, Arash¹ (AUTHOR), Sylla, Fatouomata Y. D.¹ (AUTHOR), Boukhvalova, Marina S.¹ (AUTHOR), Morrison, Trudy G.² (AUTHOR) j.blanco@sigmovir.com

Publikováno v: Viruses (1999-4915). Jun2023, Vol. 15 Issue 6, p1305. 17p.

An Optimized FI-RSV Vaccine Effectively Protects Cotton Rats and BALB/c Mice without Causing Enhanced Respiratory Disease.

Autor: Lin, Min¹ (AUTHOR), Zhang, Wei¹ (AUTHOR), Yin, Yi-Fan¹ (AUTHOR), Si, Jun-Yu¹ (AUTHOR), Zhang, Lu-Jing¹ (AUTHOR), Chen, Li¹ (AUTHOR), Lin, Xue¹ (AUTHOR), Wang, Ying-Bin¹ (AUTHOR), Zhang, Jun¹ (AUTHOR), Zheng, Zi-Zheng¹ (AUTHOR) zhengzizheng@xmu.edu.cn, Xia, Ning-Shao¹ (AUTHOR) zhengzizheng@xmu.edu.cn

Publikováno v: Viruses (1999-4915). Oct2022, Vol. 14 Issue 10, pN.PAG-N.PAG. 19p.

Immunological effects of the PE/PPE family proteins of Mycobacterium tuberculosis and related vaccines.

Autor: Fangzheng Guo, Jing Wei, Yamin Song, Baiqing Li, Zhongqing Qian, Xiaojing Wang, Hongtao Wang, Tao Xu

Publikováno v: Frontiers in Immunology; 2023, p1-17, 17p

Prior respiratory syncytial virus infection reduces vaccine-mediated Th2-skewed immunity, but retains enhanced RSV F-specific CD8 T cell responses elicited by a Th1-skewing vaccine formulation.

Autor: Eichinger, Katherine M., Kosanovich, Jessica L., Perkins, Timothy N., Oury, Tim D., Petrovsky, Nikolai, Marshall, Christopher P., Yondola, Mark A., Empey, Kerry M.

Publikováno v: Frontiers in Immunology; 10/4/2022, Vol. 13, p1-14, 14p