Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Nabila Sekkat"'
Publikováno v:
Pharmaceutical Research, Vol. 21, No 8 (2004) pp. 1390-7
The purpose of this study was (i) to validate differentially tape-stripped, porcine skin as an in vitro model for the evaluation of transdermal drug delivery (TDD) to premature neonates, (ii) to determine whether the model could estimate neonatal ski
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::65967ab4a7a299696e6f224b25542ae6
https://doi.org/10.1023/b:pham.0000036912.94452.d0
https://doi.org/10.1023/b:pham.0000036912.94452.d0
Publikováno v:
Journal of Controlled Release, Vol. 81, No 1-2 (2002) pp. 83-9
Premature neonates represent a fragile patient population, often subjected to intensive clinical care and multiple drug therapy, which must be monitored carefully and continuously. The difficult and painful nature of repetitive blood sampling, partic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2abc250849faa1dbdd68226abdc9a74c
https://doi.org/10.1016/s0168-3659(02)00046-9
https://doi.org/10.1016/s0168-3659(02)00046-9
Autor:
Catherine Anne-Marie Curdy, Ingo Alberti, Yogeshvar N. Kalia, Richard H. Guy, Nabila Sekkat, Aarti Naik
Publikováno v:
Pharmaceutical Research. 17:1148-1150
PURPOSE : To understand and account for inter-individual variations in percutaneous drug penetration and transepidermal water loss (TEWL). METHODS: TEWL is the standard measure of stratum corneum (SC) barrier function in vivo. The use of serial tape-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::af16f666965d252cd92eb89f86bc0401
https://doi.org/10.1023/a:1026474200575
https://doi.org/10.1023/a:1026474200575
Autor:
Nabila Sekkat, Richard H. Guy
Publikováno v:
Pharmacokinetic Optimization in Drug Research: Biological, Physicochemical, and Computational Strategies
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d8026db7340119b62ca5fd47d2b8e466
https://doi.org/10.1002/9783906390437.ch10
https://doi.org/10.1002/9783906390437.ch10
Publikováno v:
Journal of Pharmaceutical Sciences, Vol. 93, No 12 (2004) pp. 2936-40
The objective was to develop an in vitro model for the developing skin of the premature neonate. Barriers of different levels of efficiency were produced by differentially tape-stripping the stratum corneum (SC) from the skin of excised porcine ears,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a6afeb9e3f3293c9d7ac0dcb02c6265f
https://pubmed.ncbi.nlm.nih.gov/15459948
https://pubmed.ncbi.nlm.nih.gov/15459948
Publikováno v:
Journal of Pharmaceutical Sciences, Vol. 91, No 11 (2002) pp. 2376-81
The goal of this work was to establish, using biophysical characterization, that porcine ear skin in vitro is a valid model for its human counterpart. Specifically, stratum corneum (SC) barrier function was evaluated during its progressive removal by
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fb90e87af2c8aa89e6f7f9935f98d485
https://pubmed.ncbi.nlm.nih.gov/12379922
https://pubmed.ncbi.nlm.nih.gov/12379922
Publikováno v:
Pharmaceutical Research; Aug2004, Vol. 21 Issue 8, p1390-1397, 8p