Zobrazeno 1 - 6 of 6 pro vyhledávání: '"Nabila Brabez"'
1
Synthesis and Characterization of Time-resolved Fluorescence Probes for Evaluation of Competitive Binding to Melanocortin Receptors
Autor: Josef Vagner, Nabila Brabez, Victor J. Hruby, Eugene A. Mash, Ramesh Alleti, Robert J. Gillies, N.G.R.D. Elshan, Valerie E. Moberg, Dilani Chathurika Dehigaspitiya, Narges K. Tafreshi, Craig Weber, Ronald M. Lynch, David L. Morse
Publikováno v: Bioorganic & Medicinal Chemistry. 21:5029-5038
Probes for use in time-resolved fluorescence competitive binding assays at melanocortin receptors based on the parental ligands MSH(4), MSH(7), and NDP-α-MSH were prepared by solid phase synthesis methods, purified, and characterized. The saturation
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::08a52647dc695cb7af8d416c88b692a7
https://doi.org/10.1016/j.bmc.2013.06.052
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2
Synthesis and evaluation of cholecystokinin trimers: A multivalent approach to pancreatic cancer detection and treatment
Autor: Kara Saunders, Ryan Lacy, Solange Lavielle, Nabila Brabez, Ronald M. Lynch, Liping Xu, Robert J. Gillies, Kevin L. Nguyen, Victor J. Hruby, Gérard Chassaing
Publikováno v: Bioorganic and Medicinal Chemistry Letters
Bioorganic and Medicinal Chemistry Letters, Elsevier, 2013, 23 (8), pp.2422-2425. ⟨10.1016/j.bmcl.2013.02.022⟩
Bioorganic and Medicinal Chemistry Letters, 2013, 23 (8), pp.2422-2425. ⟨10.1016/j.bmcl.2013.02.022⟩
International audience; In the quest for novel tools for early detection and treatment of cancer, we propose the use of multimers targeting overexpressed receptors at the cancer cell surface. Indeed, multimers are prone to create multivalent interact
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::74888659b3b9a5a34258421de4e23933
https://doi.org/10.1016/j.bmcl.2013.02.022
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3
Multivalent Interactions: Synthesis and Evaluation of Melanotropin Multimers—Tools for Melanoma Targeting
Autor: Solange Lavielle, Ronald M. Lynch, Gérard Chassaing, Kevin L. Nguyen, Thanuja B M Jayasundera, Craig Weber, Nabila Brabez, Kara Saunders, Victor J. Hruby
Publikováno v: ACS Medicinal Chemistry Letters
ACS Medicinal Chemistry Letters, American Chemical Society, 2013, 4 ((1)), pp.98-102. ⟨10.1021/ml300312b⟩
ACS Medicinal Chemistry Letters, 2013, 4 ((1)), pp.98-102. ⟨10.1021/ml300312b⟩
International audience; In order to develop agents for early detection and selective treatment of melanomas, high affinity and high specificity molecular tools are required. Enhanced specificity may be obtained by simultaneously binding to multiple c
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e080d693475a7e8b08250859ad294dfb
https://doi.org/10.1021/ml300312b
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5
Design, synthesis, and biological studies of efficient multivalent melanotropin ligands: tools toward melanoma diagnosis and treatment
Autor: Ronald M. Lynch, Liping Xu, Nabila Brabez, Robert J. Gillies, Gérard Chassaing, Solange Lavielle, Victor J. Hruby
Publikováno v: Journal of Medicinal Chemistry
Journal of Medicinal Chemistry, American Chemical Society, 2011, 54 ((20)), pp.7375-84. ⟨10.1021/jm2009937⟩
Journal of Medicinal Chemistry, 2011, 54 ((20)), pp.7375-84. ⟨10.1021/jm2009937⟩
International audience; To achieve early detection and specific cancer treatment, we propose the use of multivalent interactions in which a series of binding events leads to increased affinity and consequently to selectivity. Using melanotropin (MSH)
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::655fe2bff9a9319d9ad24a9e360cc426
https://hal.archives-ouvertes.fr/hal-00688790
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