Zobrazeno 1 - 10
of 647
pro vyhledávání: '"Nabil G. Seidah"'
Autor:
Sepideh Mikaeeli, Ali Ben Djoudi Ouadda, Alexandra Evagelidis, Rachid Essalmani, Oscar Henrique Pereira Ramos, Carole Fruchart-Gaillard, Nabil G. Seidah
Publikováno v:
Cells, Vol 13, Iss 10, p 857 (2024)
PCSK9 is implicated in familial hypercholesterolemia via targeting the cell surface PCSK9-LDLR complex toward lysosomal degradation. The M2 repeat in the PCSK9’s C-terminal domain is essential for its extracellular function, potentially through its
Externí odkaz:
https://doaj.org/article/bbdbb77f86f440cd91ff249cf39ef543
Autor:
Yan Gu, Xiaozeng Lin, Ying Dong, Geoffrey Wood, Nabil G. Seidah, Geoff Werstuck, Pierre Major, Michael Bonert, Anil Kapoor, Damu Tang
Publikováno v:
Journal of Experimental & Clinical Cancer Research, Vol 42, Iss 1, Pp 1-27 (2023)
Abstract Background PCSK9 regulates cholesterol homeostasis and promotes tumorigenesis. However, the relevance of these two actions and the mechanisms underlying PCSK9’s oncogenic roles in melanoma and other cancers remain unclear. Methods PCSK9’
Externí odkaz:
https://doaj.org/article/98aedd141df64cbab5d73fa47c2b0bb2
Autor:
Emilie Wong Chong, France-Hélène Joncas, Nabil G. Seidah, Frédéric Calon, Caroline Diorio, Anne Gangloff
Publikováno v:
BMC Cancer, Vol 22, Iss 1, Pp 1-12 (2022)
Abstract Background / synopsis Cholesterol and lipids play an important role in sustaining tumor growth and metastasis in a large variety of cancers. ANGPTL3 and PCSK9 modify circulating cholesterol levels, thus availability of lipids to peripheral c
Externí odkaz:
https://doaj.org/article/1c378f79b292444eb489574381b259eb
Autor:
Carole Fruchart Gaillard, Ali Ben Djoudi Ouadda, Lidia Ciccone, Emmanuelle Girard, Sepideh Mikaeeli, Alexandra Evagelidis, Maïlys Le Dévéhat, Delia Susan-Resiga, Evelyne Cassar Lajeunesse, Hervé Nozach, Oscar Henrique Pereira Ramos, Aurélien Thureau, Pierre Legrand, Annik Prat, Vincent Dive, Nabil G. Seidah
Publikováno v:
Molecular Metabolism, Vol 67, Iss , Pp 101662- (2023)
Objective: The liver-derived circulating PCSK9 enhances the degradation of the LDL receptor (LDLR) in endosomes/lysosomes. PCSK9 inhibition or silencing is presently used in clinics worldwide to reduce LDL-cholesterol, resulting in lower incidence of
Externí odkaz:
https://doaj.org/article/25b8b2644d1147d09b7ec706733b10c7
Autor:
Paul F. Lebeau, Jae Hyun Byun, Khrystyna Platko, Paul Saliba, Matthew Sguazzin, Melissa E. MacDonald, Guillaume Paré, Gregory R. Steinberg, Luke J. Janssen, Suleiman A. Igdoura, Mark A. Tarnopolsky, S. R. Wayne Chen, Nabil G. Seidah, Jakob Magolan, Richard C. Austin
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-17 (2022)
Caffeine may reduce cardiovascular disease risk, but the underlying mechanisms for these effects are incompletely understood. Here the authors report that caffeine inhibits the activation of the transcription factor SREBP2 to promote LDLc clearance t
Externí odkaz:
https://doaj.org/article/6733f73670aa4d5a807867eed2c293ea
Autor:
Jung Min Suh, Yelin Son, Jung-Yeon Yoo, Yookyung Goh, Nabil G. Seidah, Sanghyuk Lee, Yun Soo Bae
Publikováno v:
Neoplasia: An International Journal for Oncology Research, Vol 23, Iss 9, Pp 993-1001 (2021)
Previously we demonstrated that Ahnak mediates transforming growth factor-β (TGFβ)-induced epithelial-mesenchymal transition (EMT) during tumor metastasis. It is well-known that circulating tumor cells (CTCs) invade the vasculature of adjacent targ
Externí odkaz:
https://doaj.org/article/2b988243c48b4ad689afc2b674a14241
Autor:
Justin R. Clark, Matthew Gemin, Amer Youssef, Santica M. Marcovina, Annik Prat, Nabil G. Seidah, Robert A. Hegele, Michael B. Boffa, Marlys L. Koschinsky
Publikováno v:
Journal of Lipid Research, Vol 63, Iss 6, Pp 100216- (2022)
Elevated plasma lipoprotein(a) (Lp(a)) is an independent, causal risk factor for atherosclerotic cardiovascular disease and calcific aortic valve stenosis. Lp(a) is formed in or on hepatocytes from successive noncovalent and covalent interactions bet
Externí odkaz:
https://doaj.org/article/781c7995a9834511ab3aa887d2fece44
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 10 (2022)
The PCSK9 contribution to cholesterol and immunotolerance homeostasis and response to glucose, and insulin in testis and hypophysis were studied using Pcsk9-deficient (−/−) and transgenic [Tg (PCSK9)] mice, and diabetic, obese ob/ob and db/db mic
Externí odkaz:
https://doaj.org/article/7cd333e517c8408e98cc063a5f5cd116
Autor:
Rachid Essalmani, Ursula Andréo, Alexandra Evagelidis, Maïlys Le Dévéhat, Oscar Henrique Pereira Ramos, Carole Fruchart Gaillard, Delia Susan-Resiga, Éric A. Cohen, Nabil G. Seidah
Publikováno v:
Viruses, Vol 15, Iss 2, p 360 (2023)
Proprotein convertases activate various envelope glycoproteins and participate in cellular entry of many viruses. We recently showed that the convertase furin is critical for the infectivity of SARS-CoV-2, which requires cleavage of its spike protein
Externí odkaz:
https://doaj.org/article/a6d5e3e203b24f989c24deddb4fb9949
Publikováno v:
Cells, Vol 11, Iss 24, p 4132 (2022)
Metabolic rewiring and defective immune responses are considered to be the main driving forces sustaining cell growth and oncogenesis in many cancers. The atypical enzyme, proprotein convertase subtilisin/kexin type 9 (PCSK9), is produced by the live
Externí odkaz:
https://doaj.org/article/9c5976d44e174a8e867906085340e64d