Zobrazeno 1 - 10
of 41
pro vyhledávání: '"Nabil El Tayar"'
Autor:
Nabil El Tayar
Publikováno v:
Molecular and Cellular Endocrinology. 125:65-70
The extracellular domain (ECD) of gonadotropin receptors belong to the leucine-rich repeat (LRR) protein superfamily and their transmembrane domain (TMD) is characteristic of the seven α-helices G-protein-coupled receptors (GPCR). The availability o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9636d892753d0a8c5fa25fe820a8eea2
https://doi.org/10.1016/s0303-7207(97)81878-3
https://doi.org/10.1016/s0303-7207(97)81878-3
Autor:
Buckler David Rogers, Wayne A. Hendrickson, Arnaud Ythier, Michel Dreano, Hao Wu, Nabil El Tayar, Xuliang Jiang, Cheng Shirley Vui Yen
Publikováno v:
Structure. 3:1341-1353
Background: Glycoprotein hormones influence the development and function of the ovary, testis and thyroid by binding to specific high-affinity receptors. The extracellular domains of these receptors are members of the leucine-rich repeat (LRR) protei
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c3047e5658684258ceabfd03a60406cd
https://doi.org/10.1016/s0969-2126(01)00272-6
https://doi.org/10.1016/s0969-2126(01)00272-6
Autor:
Pedro Andrade, Yvan Giroud, Bernard Testa, Pierre-Alain Carrupt, Françoise Brée, Nabil El Tayar, Jean-Paul Tillement, Ruey-Shiuan Tsai
Publikováno v:
Helvetica Chimica Acta. 76:842-854
Using the five therapeutic oxicams 1-5, we showed that isosteric replacements result in remarkable changes in the physicochemical and structural properties of congeners. Thus. the acidity of the phenolic OH group is relatively higher in the oxicams c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7b9f1b3a56bc125bf50707bf6ec41985
https://doi.org/10.1002/hlca.19930760208
https://doi.org/10.1002/hlca.19930760208
Publikováno v:
International Journal of Pharmaceutics, Vol. 80, No 1 (1992) pp. 39-49
The lipophilicity (expressed by log P(oct)) and H-bond donor acidity (expressed by DELTA-log P(oct-hep)) of the dopaminergic agonist piribedil in different ionization states were investigated in order to assess its capacity for crossing membranes. Th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::227b63f8dcbd30fd0d62f48c380fa2ab
https://doi.org/10.1016/0378-5173(92)90260-9
https://doi.org/10.1016/0378-5173(92)90260-9
Publikováno v:
Journal of Physical Chemistry, Vol. 96, No 3 (1992) pp. 1455-1459
Lipophilicity (expressed as log P, the logarithm of partition coefficients) is known to be decomposable into a cavity/volume term V expressing mainly hydrophobic and dispersive solute-solvent interactions, and polar terms reflecting electrostatic sol
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8071981a176a54bff77cd6b84a300379
https://doi.org/10.1021/j100182a078
https://doi.org/10.1021/j100182a078
Publikováno v:
Perkin Transactions 2, No 1 (1992) pp. 79-84
The distribution coefficients of free alpha-amino acids have been measured around their isoelectric value by centrifugal partition chromatography (CPC), allowing the determination of the partition coefficient (log P) of the amino acids in their zwitt
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2ed3ba600df87a238ddf0ddcc61c88fe
https://doi.org/10.1039/p29920000079
https://doi.org/10.1039/p29920000079
Autor:
Thomas Högberg, Pierre-Alain Carrupt, Ruey-Shiuan Tsai, Tomas de Paulis, Bernard Testa, Nabil El Tayar
Publikováno v:
Helvetica Chimica Acta. 74:956-968
Raclopride, an antipsychotic 6-methoxysalicylamide ( = 2-hydroxy-6-methoxybenzamide) derivative, was shown by titrimetry and UV-photometry to exist in zwitterionic form at physiological pH. Calculations revealed that the neutral and zwitterionic form
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cbfcc9acfcb109216ba6ef1f59af1c56
https://doi.org/10.1002/hlca.19910740506
https://doi.org/10.1002/hlca.19910740506
Autor:
Albert J. Leo, Bernard Testa, Pierre-Alain Carrupt, Corwin Hansch, Ruey-Shiuan Tsai, Nabil El Tayar
Publikováno v:
Journal of Pharmaceutical Sciences, Vol. 80, No 8 (1991) pp. 744-749
Human skin permeation data taken from the literature were analyzed for quantitative relationships with physicochemical properties and structural descriptors. No correlations exist with molecular weights and solvent-accessible surface areas. In most c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c313bb411e0e8d846b3eab94b29f9327
https://doi.org/10.1002/jps.2600800807
https://doi.org/10.1002/jps.2600800807
Publikováno v:
Helvetica Chimica Acta, Vol. 74, No 2 (1991) pp. 290-296
A number of isomers and analogs of the neurotoxin 1-methyl-4-phenylpyridinium (MPP+) were examined for their lipophilic behavior. Their partition coefficients in the 1-octanol/H-2O system were measured by centrifugal partition chromatography (CPC), w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0e808ce5fbce9d339149daef7052b803
https://doi.org/10.1002/hlca.19910740205
https://doi.org/10.1002/hlca.19910740205
Publikováno v:
J. Chem. Soc., Perkin Trans. 2. :1797-1802
The lipophilicity of zwitterionic amino acids was determined by measuring their distribution coefficients in an octan-1-ol–buffer system at pH values near their isoelectric point (log DI) using centrifugal partition chromatography (CPC). The observ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f5699f953950b5c85169e806954bf7a2
https://doi.org/10.1039/p29910001797
https://doi.org/10.1039/p29910001797