Finely-tuned regulation of AMP-activated protein kinase is crucial for human adult erythropoiesis

Autor: Meriem Ladli, Cyrielle Richard, Lilia Cantero Aguilar, Sarah Ducamp, Sabrina Bondu, Pierre Sujobert, Jérôme Tamburini, Catherine Lacombe, Nabih Azar, Marc Foretz, Yael Zermati, Patrick Mayeux, Benoit Viollet, Frédérique Verdier

Publikováno v: Haematologica, Vol 104, Iss 5 (2019)

AMP-activated protein kinase (AMPK) is a heterotrimeric complex containing α, β, and γ subunits involved in maintaining integrity and survival of murine red blood cells. Indeed, Ampk α1−/−, Ampk β1−/− and Ampk γ1−/− mice develop hem

Externí odkaz: https://doaj.org/article/a9a0e307e321463b82d48aac27127b72

Cost and efficacy of peripheral stem cell mobilization strategies in multiple myeloma

Autor: Lionel Karlin, Arnaud Jaccard, Margaret Macro, Cyrille Touzeau, Jean-Henri Bourhis, Arthur Bobin, Nabih Azar, Xavier Leleu, Denis Caillot, Guillemette Fouquet, Claire Darras, Laurent Garderet, Thomas Systchenko, Erik Deconinck, Samuel Limat, Cécile Gruchet, Philippe Moreau, Pascal Lenain, Isabelle Princet, Zoé Van de Wyngaert, Virginie Nerich, Christine Giraud, Marie-Lorraine Chretien, Cyrille Hulin, Ramdane Belhocine, Niels Moya, Stéphanie Guidez

Publikováno v: Bone Marrow Transplantation. 55:2254-2260

Mobilization of peripheral blood stem cells (PBSC) can be performed using plerixafor, which is expensive, or high-dose cyclophosphamide (HDCy). We hypothesized that the overall cost of mobilization with plerixafor might not be greater if the cost of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e1d46220b802cfd94dbea14972339726
https://doi.org/10.1038/s41409-020-0940-3

A Recurrent Activating Missense Mutation in Waldenström Macroglobulinemia Affects the DNA Binding of the ETS Transcription Factor SPI1 and Enhances Proliferation

Autor: Nathalie Droin, Philippe Rameau, Philippe Dessen, Florence Nguyen-Khac, Bilyana Stoilova, Elena Mylonas, Marine Armand, Damien Roos-Weil, Olivier Bernard, Els Verhoeyen, Paresh Vyas, Said Aoufouchi, Marlen Metzner, Françoise Pflumio, Frédéric Charlotte, Vincent Ribrag, Diane Lara, Olivier Elemento, Pierre Morel, Eric Durot, Cécile Hérate, Pascale Cornillet-Lefebvre, Véronique Della-Valle, Hussein Ghamlouch, Virginie Ropars, Frederik Damm, Nabih Azar, Christel Guillouf, François-Loïc Cosset, Camille Decaudin, Valérie Camara-Clayette, M'Boyba Diop, Veronique Leblond, Thomas Mercher, Jean-Baptiste Charbonnier, Rima Haddad

Publikováno v: Cancer Discovery
Cancer Discovery, American Association for Cancer Research, 2019, 9 (6), pp.796--811. ⟨10.1158/2159-8290.CD-18-0873⟩
Cancer Discovery, 2019, 9 (6), pp.796--811. ⟨10.1158/2159-8290.CD-18-0873⟩

The ETS-domain transcription factors divide into subfamilies based on protein similarities, DNA-binding sequences, and interaction with cofactors. They are regulated by extracellular clues and contribute to cellular processes, including proliferation

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bf9becc8f6995ac3fafaabe9c1fc9160
https://doi.org/10.1158/2159-8290.cd-18-0873

Plasmodium falciparum sexual parasites develop in human erythroblasts and affect erythropoiesis

Autor: Nabih Azar, Rafael M Martins, Prativa Kumari Behera, Audrey Lorthiois, Amanda K. A. Silva, Jose-Juan Lopez-Rubio, Gaelle Neveu, Pradeep Annamalai Subramani, Florence Gazeau, Catherine Lavazec, Dominique Mazier, Benjamin Marcel-Zerrougui, Samuel C. Wassmer, Sanghamitra Satpathi, Cyrielle Richard, Patrice Vallin, Aruna Mukti Minz, Frédérique Verdier, Muriel Andrieu, Florian Dupuy, Fiona Volpe

Publikováno v: Blood
Blood, American Society of Hematology, 2020, Online ahead of print, ⟨10.1182/blood.2019004746⟩
Blood, American Society of Hematology, 2020, 136 (12), pp.1381-1393. ⟨10.1182/blood.2019004746⟩
Blood, 2020, Online ahead of print (12), pp.1381-1393. ⟨10.1182/blood.2019004746⟩
Blood, American Society of Hematology, 2020, Online ahead of print (12), pp.1381-1393. ⟨10.1182/blood.2019004746⟩

Plasmodium falciparum gametocytes, the sexual stage responsible for malaria parasite transmission from humans to mosquitoes, are key targets for malaria elimination. Immature gametocytes develop in the human bone marrow parenchyma, where they accumul

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::06e6105faf929be19d07345fea8664a6
https://hal-pasteur.archives-ouvertes.fr/pasteur-02890973

Finely-tuned regulation of AMP-activated protein kinase is crucial for human adult erythropoiesis

Autor: Nabih Azar, Sarah Ducamp, Pierre Sujobert, Catherine Lacombe, Frédérique Verdier, Cyrielle Richard, Patrick Mayeux, Yael Zermati, Meriem Ladli, Marc Foretz, Sabrina Bondu, Lilia Cantero Aguilar, Benoit Viollet, Jerome Tamburini

Publikováno v: Haematologica
Haematologica, Ferrata Storti Foundation, 2019, 104 (5), pp.907-918. ⟨10.3324/haematol.2018.191403⟩

International audience; AMP-activated protein kinase (AMPK) is a heterotrimeric complex containing α, β, and γ subunits involved in maintaining integrity and survival of murine red blood cells. Indeed, Ampk α1-/- , Ampk β1-/- and Ampk γ1-/- mic

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9707f483a50a7f03c2f13031c4d50691
https://hal.archives-ouvertes.fr/hal-02348833/document