Zobrazeno 1 - 10
of 26
pro vyhledávání: '"Naazneen Khan"'
Human‐specific polymorphic pseudogenization of SIGLEC12 protects against advanced cancer progression
Autor:
Shoib S Siddiqui, Michael Vaill, Raymond Do, Naazneen Khan, Andrea L Verhagen, Wu Zhang, Heinz‐Josef Lenz, Teresa L Johnson‐Pais, Robin J Leach, Gary Fraser, Charles Wang, Gen‐Sheng Feng, Nissi Varki, Ajit Varki
Publikováno v:
FASEB BioAdvances, Vol 3, Iss 2, Pp 69-82 (2021)
Abstract Compared with our closest living evolutionary cousins, humans appear unusually prone to develop carcinomas (cancers arising from epithelia). The SIGLEC12 gene, which encodes the Siglec‐XII protein expressed on epithelial cells, has several
Externí odkaz:
https://doaj.org/article/ad2c6af5813f4af8ac528b23cfb4091c
Autor:
Joshua M. Akey, Troy J. Comi, Naazneen Khan, Hai Yu, Aniruddha Sasmal, Martin Frank, Sandra Diaz, Ajit Varki, Andrea Verhagen, Pascal Gagneux, Xi Chen, Sudeshna Saha
Publikováno v:
Molecular biology and evolution, vol 39, iss 8
SummaryLate-onset Alzheimer’s Disease (LOAD) pathology is rare in our closest living evolutionary relatives (chimpanzees), which also express much lower microglial levels of CD33(Siglec-3)–a myelomonocytic receptor inhibiting innate immune reacti
Autor:
Naazneen Khan, Aniruddha Sasmal, Zahra Khedri, Patrick Secrest, Andrea Verhagen, Saurabh Srivastava, Nissi Varki, Xi Chen, Hai Yu, Travis Beddoe, Adrienne W. Paton, James C. Paton, Ajit Varki
Publikováno v:
The Journal of biological chemistry, vol 298, iss 5
Many pathogenic bacteria secrete AB5 toxins that can be virulence factors. Cytotoxic A subunits are delivered to the cytosol following B subunit binding to specific host cell surface glycans. Some B subunits are not associated with A subunits, for ex
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8f3cfbc9aff8d3d39a7da2eb6c6ec85a
https://escholarship.org/uc/item/8jj6580k
https://escholarship.org/uc/item/8jj6580k
Human‐specific polymorphic pseudogenization of SIGLEC12 protects against advanced cancer progression
Autor:
Raymond Do, Charles Wang, Ajit Varki, Nissi Varki, Robin J. Leach, Michael Vaill, Naazneen Khan, Wu Zhang, Gen-Sheng Feng, Andrea Verhagen, Gary E. Fraser, Heinz-Josef Lenz, Shoib S. Siddiqui, Teresa L. Johnson-Pais
Publikováno v:
FASEB BioAdvances, Vol 3, Iss 2, Pp 69-82 (2021)
Compared with our closest living evolutionary cousins, humans appear unusually prone to develop carcinomas (cancers arising from epithelia). The SIGLEC12 gene, which encodes the Siglec‐XII protein expressed on epithelial cells, has several uniquely
Autor:
Aniruddha Sasmal, Naazneen Khan, Zahra Khedri, Benjamin P Kellman, Saurabh Srivastava, Andrea Verhagen, Hai Yu, Anders Bech Bruntse, Sandra Diaz, Nissi Varki, Travis Beddoe, Adrienne W Paton, James C Paton, Xi Chen, Nathan E Lewis, Ajit Varki
Publikováno v:
Glycobiology. 32(12)
Vertebrate sialic acids (Sias) display much diversity in modifications, linkages, and underlying glycans. Slide microarrays allow high-throughput explorations of sialoglycan–protein interactions. A microarray presenting ~150 structurally defined si
Autor:
Xi Chen, Ajit Varki, Brian R. Wasik, Naazneen Khan, Colin R. Parrish, Secrest P, Khedri Z, Nissi Varki, Saurabh Srivastava, Verhagen A, Hai Yu, Aniruddha Sasmal, Barbara A. Bensing, Diaz S, Paul M. Sullam
Publikováno v:
Glycobiology. 32(12)
Glycans that are abundantly displayed on vertebrate cell surface and secreted molecules are often capped with terminal sialic acids (Sias). These diverse 9-carbon-backbone monosaccharides are involved in numerous intrinsic biological processes. They
Autor:
Naazneen, Khan, Aniruddha, Sasmal, Zahra, Khedri, Patrick, Secrest, Andrea, Verhagen, Saurabh, Srivastava, Nissi, Varki, Xi, Chen, Hai, Yu, Travis, Beddoe, Adrienne W, Paton, James C, Paton, Ajit, Varki
Publikováno v:
The Journal of biological chemistry. 298(5)
Many pathogenic bacteria secrete AB
Publikováno v:
Chem Senses
Olfactory sensory neurons (OSNs) are bipolar neurons, unusual because they turn over continuously and have a multiciliated dendrite. The extensive changes in gene expression accompanying OSN differentiation in mice are largely known, especially the t
Autor:
Naazneen Khan, Yelena Alimova, Sophie J. Clark, Hemendra J. Vekaria, Adeline E. Walsh, Holden C. Williams, Gregory S. Hawk, Patrick G. Sullivan, Lance A. Johnson, Timothy S. McClintock
Publikováno v:
J Alzheimers Dis
Background: Alzheimer’s disease (AD) is a progressive age-dependent disorder whose risk is affected by genetic factors. Better models for investigating early effects of risk factors such as apolipoprotein E (APOE) genotype are needed. Objective: To
Autor:
Naazneen Khan, Chioniso P Masamha
Publikováno v:
Blood Cancer Discovery. 3:A23-A23
Mantle Cell Lymphoma (MCL) is a rare aggressive subtype of Non-Hodgkin’s Lymphoma. Upon diagnosis, treatments are varied and there is no universal standard of care. MCL is considered clinically incurable upon relapse. Better understanding of the de