Curcumin Inhibits TORC1 and Prolongs the Lifespan of Cells with Mitochondrial Dysfunction.

Autor: Naaz, Arshia¹ (AUTHOR), Zhang, Yizhong² (AUTHOR), Faidzinn, Nashrul Afiq² (AUTHOR), Yogasundaram, Sonia² (AUTHOR), Dorajoo, Rajkumar^1,3 (AUTHOR), Alfatah, Mohammad^2,4,5 (AUTHOR) alfatahm@bii.a-star.edu.sg

Publikováno v: Cells (2073-4409). Sep2024, Vol. 13 Issue 17, p1470. 13p.

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Uncharacterized yeast gene YBR238C , an effector of TORC1 signaling in a mitochondrial feedback loop, accelerates cellular aging via HAP4 - and RMD9 -dependent mechanisms.

Autor: Alfatah M; Bioinformatics Institute (BII), Agency for Science, Technology and Research (A*STAR), Singapore, Singapore., Lim JJJ; Bioinformatics Institute (BII), Agency for Science, Technology and Research (A*STAR), Singapore, Singapore., Zhang Y; Bioinformatics Institute (BII), Agency for Science, Technology and Research (A*STAR), Singapore, Singapore., Naaz A; Genome Institute of Singapore (GIS), Agency for Science, Technology and Research (A*STAR), Singapore, Singapore., Cheng TYN; Bioinformatics Institute (BII), Agency for Science, Technology and Research (A*STAR), Singapore, Singapore., Yogasundaram S; Bioinformatics Institute (BII), Agency for Science, Technology and Research (A*STAR), Singapore, Singapore., Faidzinn NA; Bioinformatics Institute (BII), Agency for Science, Technology and Research (A*STAR), Singapore, Singapore., Lin JJ; Bioinformatics Institute (BII), Agency for Science, Technology and Research (A*STAR), Singapore, Singapore., Eisenhaber B; Bioinformatics Institute (BII), Agency for Science, Technology and Research (A*STAR), Singapore, Singapore.; Genome Institute of Singapore (GIS), Agency for Science, Technology and Research (A*STAR), Singapore, Singapore.; LASA - Lausitz Advanced Scientific Applications gGmbH, Weißwasser, Germany., Eisenhaber F; Bioinformatics Institute (BII), Agency for Science, Technology and Research (A*STAR), Singapore, Singapore.; Genome Institute of Singapore (GIS), Agency for Science, Technology and Research (A*STAR), Singapore, Singapore.; LASA - Lausitz Advanced Scientific Applications gGmbH, Weißwasser, Germany.; School of Biological Sciences (SBS), Nanyang Technological University (NTU), Singapore, Singapore.

Publikováno v: ELife [Elife] 2024 May 07; Vol. 12. Date of Electronic Publication: 2024 May 07.