Zobrazeno 1 - 10
of 87
pro vyhledávání: '"Naava Naslavsky"'
Autor:
Naava Naslavsky, Steve Caplan
Publikováno v:
European Journal of Cell Biology, Vol 102, Iss 3, Pp 151339- (2023)
Despite their significance in receptor-mediated internalization and continued signal transduction in cells, early/sorting endosomes (EE/SE) remain incompletely characterized, with many outstanding questions that surround the dynamics of their size an
Externí odkaz:
https://doaj.org/article/eb26c703ffdf4f13b7fe0dee839afcd0
Autor:
Braveen B Joseph, Naava Naslavsky, Shaonil Binti, Sylvia Conquest, Lexi Robison, Ge Bai, Rafael O Homer, Barth D Grant, Steve Caplan, David S Fay
Publikováno v:
PLoS Genetics, Vol 19, Iss 4, p e1010741 (2023)
Human NIMA-related kinases have primarily been studied for their roles in cell cycle progression (NEK1/2/6/7/9), checkpoint-DNA-damage control (NEK1/2/4/5/10/11), and ciliogenesis (NEK1/4/8). We previously showed that Caenorhabditis elegans NEKL-2 (N
Externí odkaz:
https://doaj.org/article/609bdefd512d47deb4e70e27513c69db
Publikováno v:
PLoS ONE, Vol 15, Iss 9, p e0239657 (2020)
Upon internalization, receptors are trafficked to sorting endosomes (SE) where they undergo sorting and are then packaged into budding vesicles that undergo fission and transport within the cell. Eps15 Homology Domain Protein 1 (EHD1), the best-chara
Externí odkaz:
https://doaj.org/article/748c883eca0e479e8144aec9a22f7583
Publikováno v:
PLoS ONE, Vol 10, Iss 4, p e0123710 (2015)
The C-terminal Eps 15 Homology Domain proteins (EHD1-4) play important roles in regulating endocytic trafficking. EHD2 is the only family member whose crystal structure has been solved, and it contains an unstructured loop consisting of two proline-p
Externí odkaz:
https://doaj.org/article/0b3c3c73e5b444dc8287a7778509df27
Publikováno v:
PLoS ONE, Vol 8, Iss 9, p e74519 (2013)
The four mammalian C-terminal Eps15 homology domain-containing proteins (EHD1-EHD4) play pivotal roles in endocytic membrane trafficking. While EHD1, EHD3 and EHD4 associate with intracellular tubular/vesicular membranes, EHD2 localizes to the inner
Externí odkaz:
https://doaj.org/article/7725ceb105e24cb8b7b5a1956103b4e9
Autor:
Braveen B. Joseph, Naava Naslavsky, Shaonil Binti, Sylvia Conquest, Lexi Robison, Ge Bai, Barth D. Grant, Steve Caplan, David S. Fay
Human NIMA-related kinases have primarily been studied for their roles in cell cycle progression (NEK1/2/6/7/9), checkpoint–DNA-damage control (NEK1/2/4/5/10/11), and ciliogenesis (NEK1/4/8). We previously showed thatCaenorhabditis elegansNEKL-2 (N
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::226f4e2b36a3de30b2ea5c55b8c93b2f
https://doi.org/10.1101/2022.12.22.521653
https://doi.org/10.1101/2022.12.22.521653
Autor:
Naava Naslavsky, Steve Caplan
Publikováno v:
The FEBS Journal.
Endosomes play crucial roles in the cell, serving as focal and 'triage' points for internalized lipids and receptors. As such, endosomes are a critical branching point that determines whether receptors are sorted for degradation or recycling. This Vi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::84aad0a16b2dc5d1369c35a78bc5ab48
https://doi.org/10.1111/febs.16687
https://doi.org/10.1111/febs.16687
Publikováno v:
Molecular biology of the cell. 33(12)
Fission of transport vesicles from endosomes is a crucial step in the recycling of lipids and receptors to the plasma membrane, but this process remains poorly understood. Although key components of the fission machinery, including the actin cytoskel
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e52bc95e9bb044467f213d379a18f8ad
https://pubmed.ncbi.nlm.nih.gov/35921168
https://pubmed.ncbi.nlm.nih.gov/35921168
Publikováno v:
Traffic (Copenhagen, Denmark). 23(7)
The endocytic protein EHD1 controls primary ciliogenesis by facilitating fusion of the ciliary vesicle and by removal of CP110 from the mother centriole. EHD3, the closest EHD1 paralog, has a similar regulatory role, but initial evidence suggested th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2eff07749fecb5b0e9a94d1f1237cddb
https://pubmed.ncbi.nlm.nih.gov/35510564
https://pubmed.ncbi.nlm.nih.gov/35510564