Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Naama, Hen"'
Autor:
Yuri Goldes, Amotz Shemi, Eliel Ben David, Stephen Raskin, Elina Zorde Khvalevsky, Maor Lahav, Eithan Galun, Yael Kopleman, Abraham J. Domb, Talia Golan, Rachel Malka Gabai, Naama Hen, Alain Dancour, Amiel Segal, Eran Goldin, Ayala Hubert, Rami Eliakim, Gil Harari
Publikováno v:
Oncotarget
// Talia Golan 1 , Elina Zorde Khvalevsky 2 , Ayala Hubert 3 , Rachel Malka Gabai 2 , Naama Hen 2 , Amiel Segal 4 , Abraham Domb 5 , Gil Harari 6 , Eliel Ben David 7 , Stephen Raskin 1 , Yuri Goldes 1 , Eran Goldin 8 , Rami Eliakim 1 , Maor Lahav 1 ,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::565ec13ca5e2f86eb464a14fd8791147
https://doi.org/10.18632/oncotarget.4183
https://doi.org/10.18632/oncotarget.4183
Publikováno v:
Epilepsia. 54:99-102
Summary sec-Butyl-propylacetamide (SPD) is a one-carbon homolog of valnoctamide (VCD), a chiral constitutional isomer of valproic acid's (VPA) corresponding amide valpromide. VCD has potential as a therapy in epilepsy including status epilepticus (SE
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::634b643eaf1a5629015f0e7fd4f7331a
https://doi.org/10.1111/epi.12290
https://doi.org/10.1111/epi.12290
Autor:
Meir Bialer, Wendy A. Pouliot, K. Ricks, C. Nelson, Tawfeeq Shekh-Ahmad, F.E. Dudek, Naama Hen, Boris Yagen, Bonnie Roach, Dan Kaufmann
Publikováno v:
Neuroscience. 231:145-156
Better treatment of status epilepticus (SE), which typically becomes refractory after about 30 min, will require new pharmacotherapies. The effect of sec-butyl-propylacetamide (SPD), an amide derivative of valproic acid (VPA), on electrographic statu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::08d9fd81652e547d13ab0753b9743747
https://doi.org/10.1016/j.neuroscience.2012.11.005
https://doi.org/10.1016/j.neuroscience.2012.11.005
Publikováno v:
Journal of Medicinal Chemistry. 55:2835-2845
A novel class of 19 carbamates was synthesized, and their anticonvulsant activity was comparatively evaluated in the rat maximal electroshock (MES) and subcutaneous metrazol (scMet) seizure tests and pilocarpine-induced status epilepticus (SE) model.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fe5bb706c48671f9f821b5cfa8076672
https://doi.org/10.1021/jm201751x
https://doi.org/10.1021/jm201751x
Autor:
James P. Stables, Naama Hen, John H. McDonough, Amanda L. Pollock, H. Steve White, Dan Kaufmann, Anitha Alex, Karen S. Wilcox, Meir Bialer, Boris Yagen, Tawfeeq Shekh-Ahmad
Publikováno v:
Epilepsia. 53:134-146
Purpose sec-Butyl-propylacetamide (SPD) is a one-carbon homologue of valnoctamide (VCD), a CNS-active amide derivative of valproic acid (VPA) currently in phase II clinical trials. The current study evaluated the anticonvulsant activity of SPD in a b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8c70ce7ef477c3aaa5c4aac22b1989c4
https://doi.org/10.1111/j.1528-1167.2011.03338.x
https://doi.org/10.1111/j.1528-1167.2011.03338.x
Autor:
Andrea Scozzafava, Boris Yagen, Robert McKenna, Claudiu T. Supuran, Naama Hen, Alfonso Maresca, Mayank Aggarwal, Arthur H. Robbins, Meir Bialer
Publikováno v:
Journal of Medicinal Chemistry; Vol 54
Aromatic amides comprising branched aliphatic carboxylic acids and 4-aminobenzenesulfonamide were evaluated for their inhibition of carbonic anhydrase (CA) isoforms. Of the most anticonvulsant-active compounds (2, 4, 13, 16, and 17), only 13, 16, and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5baab1f9ebd4230dc4ee3cf51b131671
Autor:
Naama Hen, Richard H. Finnell, Neta Pessah, Bogdan J. Wlodarczyk, Boris Yagen, Meir Bialer, Dan Kaufmann
Publikováno v:
Epilepsia. 51:1944-1953
Summary Purpose: α-Fluoro-2,2,3,3-tetramethylcyclopropanecarboxamide (α-F-TMCD) and α-Cl-TMCD, are α-halo derivatives of TMCD, the corresponding amide of a cyclopropane analog of valproic acid (VPA). This study aimed to comparatively evaluate the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6c4bb4f9395538ce13db0dbc39f80a51
https://doi.org/10.1111/j.1528-1167.2010.02684.x
https://doi.org/10.1111/j.1528-1167.2010.02684.x
Publikováno v:
Journal of Medicinal Chemistry. 53:4177-4186
Despite the availability of 14 new antiepileptic drugs (AEDs), about 30% of epileptic patients are not seizure-free. Consequently there is substantial need to develop new effective AEDs. A novel class of aromatic amides composed of phenylacetic acid
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6a7fc2f7a0909dd600800f1d02499b34
https://doi.org/10.1021/jm100170w
https://doi.org/10.1021/jm100170w
Autor:
Richard H. Finnell, Boris Yagen, Naama Hen, Meir Bialer, John H. McDonough, Bogdan J. Wlodarczyk, Tawfeeq Shekh-Ahmad
Summary Objective Valnoctamide (VCD), a central nervous system (CNS)–active chiral constitutional isomer of valpromide, the corresponding amide of valproic acid (VPA), is currently undergoing phase IIb clinical trials in acute mania. VCD exhibits s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1897f964fba1502320fa8d51cde27c55
https://europepmc.org/articles/PMC4963464/
https://europepmc.org/articles/PMC4963464/
Autor:
Yuko, Onishi, Akinobu, Okada, Hiroko, Noyori, Ai, Okamura, Naama, Hen, Boris, Yagen, Meir, Bialer, Michio, Fujiwara
Publikováno v:
Birth defects research. Part B, Developmental and reproductive toxicology. 98(4)
Valproic acid (VPA), widely used to treat epilepsy, bipolar disorders, and migraine prophylaxis, is known to cause neural tube and skeletal defects in humans and animals. Aminobenzensulfonamide derivatives of VPA with branched aliphatic carboxylic ac
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::0f2a8215710e3466d230e2ee0eb10dbc
https://pubmed.ncbi.nlm.nih.gov/24039104
https://pubmed.ncbi.nlm.nih.gov/24039104