Memantine treatment does not affect compulsive behavior or frontostriatal connectivity in an adolescent rat model for quinpirole-induced compulsive checking behavior

Autor: Straathof, M., Blezer, E.L.A., Smeele, C.E., Heijningen, C. van, Toorn, A. van der, Buitelaar, J.K., Glennon, J.C., Naaijen, J., Akkermans, S.E.A., Mennes, M.J.J., Zwiers, M.P., Ilbegi, S., Hennissen, L., Vondervoort, I.I.G.M. van de, Kapusta, K.A., Bielczyk, N.Z., Amiri, H., Havenith, M.N., Franke, B., Poelmans, G.J.V., Bralten, J.B., Heskes, T., Sokolova, E.S., Groot, P., Otte, W.M., Dijkhuizen, R.M.

Publikováno v: TACTICS Consortium 2022, ' Memantine treatment does not affect compulsive behavior or frontostriatal connectivity in an adolescent rat model for quinpirole-induced compulsive checking behavior ', Psychopharmacology, vol. 239, no. 8, pp. 2457-2470 . https://doi.org/10.1007/s00213-022-06139-z
Psychopharmacology, 239, 2457-2470
PSYCHOPHARMACOLOGY
Psychopharmacology, 239(8), 2457-2470. Springer Verlag
Psychopharmacology, 239, 8, pp. 2457-2470

Rationale Compulsivity often develops during childhood and is associated with elevated glutamate levels within the frontostriatal system. This suggests that anti-glutamatergic drugs, like memantine, may be an effective treatment. Objective Our goal w

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::090e1349563e03f387c6cc9476f59b89
https://research.vumc.nl/en/publications/7d730c36-f39b-46e3-9b2d-d05af31997f7

The causal role of glutamate and GABA genetics on behavioural autism characteristics and brain structure

Autor: Hollestein, V., Claasen, T., Buitelaar, J., Naaijen, J.

Publikováno v: In Neuroscience Applied 2022 1 Supplement 1

Basal ganglia structure in Tourette's disorder and/or attention-deficit/hyperactivity disorder

Autor: Forde, J.N., Zwiers, M.P., Naaijen, J., Akkermans, S.E.A., Openneer, T.J., Visscher, F., Dietrich, A., Buitelaar, J.K., Hoekstra, P.J.

Publikováno v: Movement Disorders, 32, 4, pp. 601-604
Movement Disorders, 32, 601-604

Contains fulltext : 174887.pdf (Publisher’s version ) (Closed access) BACKGROUND: Tourette's disorder and attention-deficit/hyperactivity disorder often co-occur and have both been associated with structural variation of the basal ganglia. However,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::f968967dc0cdcf6d538b6c0daedd7340
https://doi.org/10.1002/mds.26849

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