Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Na Yoon Paik"'
Autor:
Kilian Sottoriva, Na Yoon Paik, Zachary White, Thilinie Bandara, Lijian Shao, Teruyuki Sano, Kostandin V. Pajcini
Publikováno v:
JCI Insight, Vol 7, Iss 9 (2022)
Long-term impairment in T cell–mediated adaptive immunity is a major clinical obstacle following treatment of blood disorders with hematopoietic stem cell transplantation. Although T cell development in the thymus has been extensively characterized
Externí odkaz:
https://doaj.org/article/e14c47cc97674980b7c99037dc1b8d44
Autor:
Lijian Shao, Kilian Sottoriva, Karol Palasiewicz, Jizhou Zhang, James Hyun, Sweta S. Soni, Na Yoon Paik, Xiaopei Gao, Henar Cuervo, Asrar B. Malik, Jalees Rehman, Daniel Lucas, Kostandin V. Pajcini
Publikováno v:
Haematologica, Vol 104, Iss 11 (2019)
Loss-of-function studies have determined that Notch signaling is essential for hematopoietic and endothelial development. By deleting a single allele of the Notch1 transcriptional activation domain we generated viable, post-natal mice exhibiting hypo
Externí odkaz:
https://doaj.org/article/c7d358a8235d4d9c9812091cb315a357
Autor:
Sunil S. Raikar, Lauren C. Fleischer, Robert Moot, Andrew Fedanov, Na Yoon Paik, Kristopher A. Knight, Christopher B. Doering, H. Trent Spencer
Publikováno v:
OncoImmunology, Vol 7, Iss 3 (2018)
Relapsed T-cell malignancies have poor outcomes when treated with chemotherapy, but survival after allogeneic bone marrow transplantation (BMT) approaches 50%. A limitation to BMT is the difficulty of achieving remission prior to transplant. Chimeric
Externí odkaz:
https://doaj.org/article/595175915e694c6f9cbda7b8ad257be9
Autor:
Allison M Lytle, Harrison C Brown, Na Yoon Paik, Kristopher A Knight, J Fraser Wright, H Trent Spencer, Christopher B Doering
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 3, Iss C (2016)
Immune responses to coagulation factors VIII (FVIII) and IX (FIX) represent primary obstacles to hemophilia treatment. Previously, we showed that hematopoietic stem cell (HSC) retroviral gene therapy induces immune nonresponsiveness to FVIII in both
Externí odkaz:
https://doaj.org/article/8d2ed94f878744bcbf391d34f101c04b
Autor:
Timothy Sargis, Seock-Won Youn, Krishna Thakkar, L. A. Naiche, Na Yoon Paik, Kostandin V. Pajcini, Jan K. Kitajewski
Publikováno v:
Angiogenesis. 26:249-263
The Notch signaling pathway is an important therapeutic target for the treatment of inflammatory diseases and cancer. We previously created ligand-specific inhibitors of Notch signaling comprised of Fc fusions to specific EGF-like repeats of the Notc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f2369a86c5a4a39e3966da687e83f22b
https://doi.org/10.1007/s10456-022-09861-6
https://doi.org/10.1007/s10456-022-09861-6
Autor:
Lijian Shao, Na Yoon Paik, Mark A. Sanborn, Thilinie Bandara, Anjali Vijaykumar, Kilian Sottoriva, Jalees Rehman, Cesar Nombela-Arrieta, Kostandin V. Pajcini
Publikováno v:
Proceedings of the National Academy of Sciences. 120
Notch signaling is essential for the emergence of definitive hematopoietic stem cells (HSCs) in the embryo and their development in the fetal liver niche. However, how Notch signaling is activated and which fetal liver cell type provides the ligand f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4bd8f99fb8dd229c8d74c41b55057bbc
https://doi.org/10.1073/pnas.2210058120
https://doi.org/10.1073/pnas.2210058120
Autor:
Shao, Lijian, Na Yoon Paik, Sanborn, Mark A., Bandara, Thilinie, Vijaykumar, Anjali, Sottoriva, Kilian, Rehman, Jalees, Nombela-Arrieta, Cesar, Pajcini, Kostandin V.
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America; 5/16/2023, Vol. 120 Issue 20, p1-10, 48p
Autor:
Kilian Sottoriva, Na Yoon Paik, Zachary White, Thilinie Bandara, Lijian Shao, Teruyuki Sano, Kostandin V. Pajcini
Publikováno v:
JCI insight. 7(9)
Long-term impairment in T cell-mediated adaptive immunity is a major clinical obstacle following treatment of blood disorders with hematopoietic stem cell transplantation. Although T cell development in the thymus has been extensively characterized,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ffdffba2f7c77576c019dcd4f539d772
https://pubmed.ncbi.nlm.nih.gov/35349492
https://pubmed.ncbi.nlm.nih.gov/35349492
Autor:
Kilian Sottoriva, Karol Palasiewicz, James Hyun, Xiaopei Gao, Henar Cuervo, Sweta S. Soni, Na Yoon Paik, Asrar B. Malik, Kostandin V. Pajcini, Lijian Shao, Jalees Rehman, Jizhou Zhang, Daniel Lucas
Publikováno v:
Haematologica. 104:2164-2177
Loss-of-function studies have determined that Notch signaling is essential for hematopoietic and endothelial development. By deleting a single allele of the Notch1 transcriptional activation domain we generated viable, post-natal mice exhibiting hypo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1b50bf51accaad0de8bd8ae559dbba2e
https://doi.org/10.3324/haematol.2018.208660
https://doi.org/10.3324/haematol.2018.208660
Autor:
Andrew Fedanov, Christopher B. Doering, Chengyu Prince, Sarah E Takushi, Na Yoon Paik, H. Trent Spencer, Shanmuganathan Chandrakasan
Publikováno v:
Hum Gene Ther
Familial hemophagocytic lymphohistiocytosis type 3 (FHL3) is a rare disease caused by mutations to the UNC13D gene and the subsequent absence or decreased activity of the Munc13-4 protein. Munc13-4 is essential for the exocytosis of perforin and gran
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ef2663da167fe090824c71b0781b7217
https://europepmc.org/articles/PMC7310202/
https://europepmc.org/articles/PMC7310202/
