Zobrazeno 1 - 10
of 111
pro vyhledávání: '"Naír Rodríguez-Hornedo"'
Publikováno v:
Pharmaceutics, Vol 13, Iss 3, p 433 (2021)
Knowledge of the stability of pharmaceutical formulations against relative humidity (RH) is essential if they are to become pharmaceutical products. The increasing interest in formulating active pharmaceutical ingredients as stable co-crystals (CCs)
Externí odkaz:
https://doaj.org/article/e88d0c0cdd0e4cfe8f8f91fd7135ee5a
Autor:
Alanny B. O. Rocha, Gislaine Kuminek, Tatiane C. Machado, Juliana Rosa, Gabriela S. Rauber, Paola A. A. Borba, Sana Siedler, Hellen K. Stulzer, Silvia Lucia Cuffini, Naír Rodríguez-Hornedo, Simone G. Cardoso
Publikováno v:
Química Nova, Vol 39, Iss 9, Pp 1112-1125
Pharmaceutical cocrystals have emerged as a useful strategy to improve the aqueous solubility of poorly water soluble drugs by aiming to enhance their oral absorption and bioavailability. Aqueous cocrystal solubility can be orders of magnitude higher
Externí odkaz:
https://doaj.org/article/3125d19d0dc44c3eaf35dc1df0dd3e66
Publikováno v:
Molecular Pharmaceutics. 19:2765-2775
A graphical analysis of both drug and coformer concentrations contributed by dissolving cocrystals is presented in the context of a simplified cocrystal phase diagram. The conceptual basis and analysis identify parameters that control cocrystal disso
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ae2f07042e63fed348325cda27204cb4
https://doi.org/10.1021/acs.molpharmaceut.2c00122
https://doi.org/10.1021/acs.molpharmaceut.2c00122
Publikováno v:
Crystal Growth & Design. 22:1528-1532
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::91103f69fc57da41db20bd0dcf82c60e
https://doi.org/10.1021/acs.cgd.1c01241
https://doi.org/10.1021/acs.cgd.1c01241
Publikováno v:
Crystal Growth & Design. 21:4445-4455
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7873af6cbe3ec9a80b79746faf8ed2b1
https://doi.org/10.1021/acs.cgd.1c00355
https://doi.org/10.1021/acs.cgd.1c00355
Publikováno v:
Molecular Pharmaceutics. 17:4286-4301
Two of the main questions regarding cocrystal selection and formulation development are whether the will be stable and how fast can it dissolve the drug dose. Dissolving the drug dose may require cocrystals with a high solubility advantage over drug
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a9d1c65d3a9a165c07ffd4a5d93097df
https://doi.org/10.1021/acs.molpharmaceut.0c00713
https://doi.org/10.1021/acs.molpharmaceut.0c00713
Autor:
Jie Tang, Richard Schutzman, Carlos A. Rodríguez, Joerg Lahann, Naír Rodríguez-Hornedo, Mark R. Prausnitz, Steven P. Schwendeman
Publikováno v:
Journal of controlled release : official journal of the Controlled Release Society. 341
Despite its high efficacy and good patient compliance, the only long-acting injectable (LAI) contraceptive currently available in the US, depot medroxyprogesterone acetate (DMPA), is limited by significant side effects and a delayed return to fertili
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b18d7d5a823e9eebfbf9f2ef3653f03b
https://pubmed.ncbi.nlm.nih.gov/34921972
https://pubmed.ncbi.nlm.nih.gov/34921972
Publikováno v:
Crystal Growth & Design. 19:6592-6602
This work reports the first cocrystal of the basic drug posaconazole (PSZ). PSZ is poorly water-soluble and has low and erratic bioavailability based on its large positive food effect and high solu...
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fd32b8ac5510d5b65f4fd4ead2f5a4cf
https://doi.org/10.1021/acs.cgd.9b01026
https://doi.org/10.1021/acs.cgd.9b01026
Autor:
Qiuxiang Yin, Gislaine Kuminek, Lilly Roy, Naír Rodríguez-Hornedo, Yaohui Huang, Katie L. Cavanagh
Publikováno v:
Molecular Pharmaceutics. 16:3887-3895
Cocrystals are often more soluble than needed and pose unnecessary risks for precipitation of less soluble forms of the drug during processing and dissolution. Such conversions lead to erratic cocrystal behavior and nullify the cocrystal solubility a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ad44bc1f472a69ef11eb0225d8354a53
https://doi.org/10.1021/acs.molpharmaceut.9b00501
https://doi.org/10.1021/acs.molpharmaceut.9b00501
Publikováno v:
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences. 152
Cocrystals that are more soluble than the constituent drug, generate supersaturation levels during dissolution and are predisposed to conversion to the less soluble drug. Drug release studies during cocrystal dissolution generally compare several coc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::76a283cf99f3fb2b922983460cfa59a0
https://pubmed.ncbi.nlm.nih.gov/32531350
https://pubmed.ncbi.nlm.nih.gov/32531350