Venetoclax enhances T cell–mediated antileukemic activity by increasing ROS production

Autor: Lee, Jong Bok, Khan, Dilshad H., Hurren, Rose, Xu, Mingjing, Na, Yoosu, Kang, Hyeonjeong, Mirali, Sara, Wang, Xiaoming, Gronda, Marcela, Jitkova, Yulia, MacLean, Neil, Arruda, Andrea, Alaniz, Zoe, Konopleva, Marina Y., Andreeff, Michael, Minden, Mark D., Zhang, Li ^**, Schimmer, Aaron D. ^*

Publikováno v: In Blood 22 July 2021 138(3):234-245

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Acute myeloid leukemia drug tolerant persister cells survive chemotherapy by transiently increasing plasma membrane rigidity, that also increases their sensitivity to immune cell killing.

Autor: Morgenstern Y; Princess Margaret Cancer Centre, University Health Network, Toronto., Lee J; Toronto General Hospital Research Institute, University Health Network, Toronto., Na Y; Toronto General Hospital Research Institute, University Health Network, Toronto., Lieng BY; Terrence Donnelly Centre for Cellular and Biomolecular Research, University of Toronto, Toronto., Ly NS; Terrence Donnelly Centre for Cellular and Biomolecular Research, University of Toronto, Toronto., Gwynne WD; Terrence Donnelly Centre for Cellular and Biomolecular Research, University of Toronto, Toronto., Hurren R; Princess Margaret Cancer Centre, University Health Network, Toronto., Ma L; Princess Margaret Cancer Centre, University Health Network, Toronto., Ling D; Princess Margaret Cancer Centre, University Health Network, Toronto., Gronda M; Princess Margaret Cancer Centre, University Health Network, Toronto., Arruda A; Princess Margaret Cancer Centre, University Health Network, Toronto., Frisch A; Department of Hematology and Bone Marrow Transplantation, Rambam Health Care Campus, Haifa, Israel., Zuckerman T; Department of Hematology and Bone Marrow Transplantation, Rambam Health Care Campus, Haifa, Israel., Ofran Y; Hematology and Stem cell transplantation department and the Eisenberg R-D Authority, Shaare Zedek medical center, Hebrew University Jerusalem, Israel., Minden MD; Princess Margaret Cancer Centre, University Health Network, Toronto., Zhang L; Toronto General Hospital Research Institute, University Health Network, Toronto., O'Brien C; Princess Margaret Cancer Centre, University Health Network, Toronto., Quaile AT; Terrence Donnelly Centre for Cellular and Biomolecular Research, University of Toronto, Toronto., Montenegro-Burke JR; Terrence Donnelly Centre for Cellular and Biomolecular Research, University of Toronto, Toronto., Schimmer AD; Princess Margaret Cancer Centre, University Health Network, Toronto. Aaron.schimmer@uhn.ca.

Publikováno v: Haematologica [Haematologica] 2024 Nov 21. Date of Electronic Publication: 2024 Nov 21.