Zobrazeno 1 - 10
of 188
pro vyhledávání: '"NUAK1"'
Autor:
Mario Palma, Elizabeth Riffo, Alejandro Farias, Viviana Coliboro-Dannich, Luis Espinoza-Francine, Emilia Escalona, Roberto Amigo, José L. Gutiérrez, Roxana Pincheira, Ariel F. Castro
Publikováno v:
Cell & Bioscience, Vol 13, Iss 1, Pp 1-22 (2023)
Abstract Background mTORC2 is a critical regulator of cytoskeleton organization, cell proliferation, and cancer cell survival. Activated mTORC2 induces maximal activation of Akt by phosphorylation of Ser-473, but regulation of Akt activity and signal
Externí odkaz:
https://doaj.org/article/b147c3f3e6e94b8ca50919e790866969
Autor:
Huiru Yang, Zhen Wei, Yifan Song, Kexin Du, Nannan Yin, Hong Lu, Bingbing Li, Lili Hou, Panfei Xing, Liang Chen, Chaojie Wang, Songqiang Xie
Publikováno v:
Cancer Cell International, Vol 23, Iss 1, Pp 1-18 (2023)
Abstract Background Metastasis is still a major cause of poor pathological outcome and prognosis in esophageal squamous cell carcinoma (ESCC) patients. NUAK1 has been reported highly expressed in many human cancers and is associated with the poor pro
Externí odkaz:
https://doaj.org/article/b0d06a21113e432d89b794f2649a1c70
Autor:
Declan Whyte, George Skalka, Peter Walsh, Ania Wilczynska, Nikki R. Paul, Claire Mitchell, Colin Nixon, William Clarke, Martin Bushell, Jennifer P. Morton, Daniel J. Murphy, Nathiya Muthalagu
Publikováno v:
Molecular Oncology, Vol 17, Iss 7, Pp 1212-1227 (2023)
The AMP‐activated protein kinase (AMPK)‐related kinase NUAK1 (NUAK family SNF1‐like kinase 1) has emerged as a potential vulnerability in MYC‐dependent cancer but the biological roles of NUAK1 in different settings are poorly characterised, a
Externí odkaz:
https://doaj.org/article/6896303684144ae5bf0d4de609aa31de
Akademický článek
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Akademický článek
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Akademický článek
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Autor:
Myeong-Seong Seo, Kyung Hee Jung, Kewon Kim, Ji Eun Lee, Beom Seok Han, Soyeon Ko, Jae Ho Kim, Sungwoo Hong, So Ha Lee, Soon-Sun Hong
Publikováno v:
Biomedicine & Pharmacotherapy, Vol 152, Iss , Pp 113241- (2022)
The novel (nua) kinase family 1 (NUAK1) is an AMPK-related kinase and its expression is associated with tumor malignancy and poor prognosis in several types of cancer, suggesting its potential as a target for cancer therapy. Therefore, the developmen
Externí odkaz:
https://doaj.org/article/cf87912a9a5842c19ae1ef017efbe152
Publikováno v:
Cancer Cell International, Vol 21, Iss 1, Pp 1-16 (2021)
Abstract Background Cholangiocarcinoma (CCA) is the second most common primary liver malignancy worldwide. Several microRNAs (miRNAs) have been implicated as potential tumor suppressors in CCA. This study aims to explore the potential effects of miR-
Externí odkaz:
https://doaj.org/article/1a70a9d926214be9a6e608d628ac7a61
Publikováno v:
Cancer Management and Research, Vol Volume 12, Pp 13357-13368 (2020)
Ming-Ming Zhao, Lin-Yang Ge, Liang-Feng Yang, Hai-Xia Zheng, Gang Chen, Li-Zheng Wu, Shao-Ming Shi, Nan Wang, Yan-Ping Hang Department of Respiratory and Critical Care Medicine, People’s Hospital of Gaochun, Nanjing 211300, People’s Republic of C
Externí odkaz:
https://doaj.org/article/a01d7e5d5f954638bcbc09e3f3e0291f
Autor:
Seunghee Oh, Jaehyoun Lee, Selene K Swanson, Laurence Florens, Michael P Washburn, Jerry L Workman
Publikováno v:
eLife, Vol 9 (2020)
Changes in available nutrients are inevitable events for most living organisms. Upon nutritional stress, several signaling pathways cooperate to change the transcription program through chromatin regulation to rewire cellular metabolism. In budding y
Externí odkaz:
https://doaj.org/article/332fffdb5a464fb5a13bd15d383c97c2