Zobrazeno 1 - 10
of 298
pro vyhledávání: '"NTRK-fusion"'
Autor:
Eric Eunshik Kim, Chul-Kee Park, Seung-Ki Kim, Ji Hoon Phi, Sun Ha Paek, Jung Yoon Choi, Hyoung Jin Kang, Joo Ho Lee, Jae Kyung Won, Hongseok Yun, Sung-Hye Park
Publikováno v:
Acta Neuropathologica Communications, Vol 12, Iss 1, Pp 1-13 (2024)
Abstract Background Neurotrophic tropomyosin receptor kinase (NTRK) gene fusions are found in 1% of gliomas across children and adults. TRK inhibitors are promising therapeutic agents for NTRK-fused gliomas because they are tissue agnostic and cross
Externí odkaz:
https://doaj.org/article/b9baee58d05a4479b011d7d13a68747e
Autor:
Abdul Rehman Syed, Aakash Gorana, Erik Nohr, Xiaoli-Kat Yuan, Parthiv Amin MASc, Sana Ghaznavi, Debbie Lamb, John McIntyre, Markus Eszlinger, Ralf Paschke
Publikováno v:
European Thyroid Journal, Vol 13, Iss 3, Pp 1-10 (2024)
Context: Two-thirds of metastatic differentiated thyroid cancer (DTC) patients have radioiodine (RAI)-resistant disease, resulting in poor prognosis and high mortality. For rare NTRK and RET fusion-positive metastatic, RAI-resistant thyroid cancers,
Externí odkaz:
https://doaj.org/article/38d26f050f294e1ea4ce0ff73d3443c5
Autor:
Etsuko Moriyama, Sachiko Nagasu, Toshimitsu Tanaka, Yasutaka Shimotsuura, Takeharu Ono, Hirohito Umeno, Jun Akiba, Akihiko Kawahara, Fumihiko Fujita, Takumi Kawaguchi, Keisuke Miwa
Publikováno v:
Frontiers in Oncology, Vol 13 (2023)
IntroductionExpression of the NTRK gene is rare in solid tumors but is highly prevalent in salivary gland secretory carcinomas. Here, we report a case of a complete response to entrectinib in a patient with NTRK fusion gene-positive parotid carcinoma
Externí odkaz:
https://doaj.org/article/45cb8b3a60314a6b90e4a2ad32d1cbf3
Autor:
Marco M. Bühler, Hanna Honcharova-Biletska, Chantal Pauli, Dimitrios Chronas, Kristina Bolten
Publikováno v:
Gynecologic Oncology Reports, Vol 48, Iss , Pp 101233- (2023)
In depth molecular studies are constantly expanding our understanding and refining the classification of gynecological neoplasms. NTRK rearranged spindle cell neoplasms of the lower genital tract are an emerging entity, of particular interest due to
Externí odkaz:
https://doaj.org/article/3face2c61a404f9dacc4fa3b5e60d42a
Autor:
Misove Adela, Vicha Ales, Broz Petr, Vanova Katerina, Sumerauer David, Stolova Lucie, Sramkova Lucie, Koblizek Miroslav, Zamecnik Josef, Kyncl Martin, Holubova Zuzana, Liby Petr, Taborsky Jakub, Benes Vladimir, Pernikova Ivana, Jones T. W. David, Sill Martin, Stancokova Terezia, Krskova Lenka, Zapotocky Michal
Publikováno v:
Acta Neuropathologica Communications, Vol 10, Iss 1, Pp 1-11 (2022)
Abstract Gliomas are the most common central nervous tumors in children and adolescents. However, spinal cord low-grade gliomas (sLGGs) are rare, with scarce information on tumor genomics and epigenomics. To define the molecular landscape of sLGGs, w
Externí odkaz:
https://doaj.org/article/04ebcb878541477ab933f746049edf2a
Publikováno v:
Asian Journal of Surgery, Vol 46, Iss 10, Pp 4435-4436 (2023)
Externí odkaz:
https://doaj.org/article/83a27e9c7730451ca8e58df4b54b2464
Autor:
Mary C. Boulanger, MD, Jennifer S. Temel, MD, Mari Mino-Kenudson, MD, Lauren L. Ritterhouse, MD, PhD, Ibiayi Dagogo-Jack, MD
Publikováno v:
JTO Clinical and Research Reports, Vol 4, Iss 4, Pp 100501- (2023)
The NTRK genes encode the TRK proteins. NTRK fusions lead to constitutively active, ligand-independent downstream signaling. NTRK fusions are implicated in up to 1% of all solid tumors and 0.2% of NSCLC. Larotrectinib, a highly selective small molecu
Externí odkaz:
https://doaj.org/article/4f543e45c5e04d4c99b768fed1a7106e
Autor:
Susanne Ghandili, Judith Dierlamm, Carsten Bokemeyer, Clara Marie von Bargen, Sören Alexander Weidemann
Publikováno v:
Frontiers in Oncology, Vol 13 (2023)
BackgroundEven though two NTRK-targeting drugs are available for the treatment of irresectable, metastatic, or progressive NTRK-positive solid tumors, less is known about the role of NTRK fusions in lymphoma. For this reason, we aimed to investigate
Externí odkaz:
https://doaj.org/article/cb957c106cd04ba6b62633422fac6861
Publikováno v:
Frontiers in Oncology, Vol 13 (2023)
COL1A1–PDGFB gene fusion uterine sarcoma is an especially rare malignant mesenchymal tumor that was previously classified as an undifferentiated uterine sarcoma due to the lack of specific features of differentiation. Till now, only five cases have
Externí odkaz:
https://doaj.org/article/5e019762092a41dc836c2651be2b173e
Autor:
Vasiliki Siozopoulou, Elly Marcq, Koen De Winne, Koen Norga, Gertjan Schmitz, Valerie Duwel, Philippe Delvenne, Evelien Smits, Patrick Pauwels
Publikováno v:
Pathology and Oncology Research, Vol 28 (2022)
Targeting molecular alterations has been proven to be an inflecting point in tumor treatment. Especially in recent years, inhibitors that target the tyrosine receptor kinase show excellent response rates and durable effects in all kind of tumors that
Externí odkaz:
https://doaj.org/article/0c194190c2a14a9a8d6fd0293ef53a92