Zobrazeno 1 - 10
of 1 635
pro vyhledávání: '"NTRK"'
Publikováno v:
Case Reports in Oncology, Vol 17, Iss 1, Pp 960-965 (2024)
Introduction: Here, we report the first case of a soft tissue tumor with a PAK2::RAF1 fusion. Case Presentation: The patient was an 11-year-old female presenting with a 5 cm intramuscular mass in the lower leg. Microscopic examination revealed a mito
Externí odkaz:
https://doaj.org/article/8d7af6e1416242ea86eac67814fc0438
Autor:
Eric Eunshik Kim, Chul-Kee Park, Seung-Ki Kim, Ji Hoon Phi, Sun Ha Paek, Jung Yoon Choi, Hyoung Jin Kang, Joo Ho Lee, Jae Kyung Won, Hongseok Yun, Sung-Hye Park
Publikováno v:
Acta Neuropathologica Communications, Vol 12, Iss 1, Pp 1-13 (2024)
Abstract Background Neurotrophic tropomyosin receptor kinase (NTRK) gene fusions are found in 1% of gliomas across children and adults. TRK inhibitors are promising therapeutic agents for NTRK-fused gliomas because they are tissue agnostic and cross
Externí odkaz:
https://doaj.org/article/b9baee58d05a4479b011d7d13a68747e
Autor:
Luigia Turco, Rosa Della Monica, Pasqualina Giordano, Mariella Cuomo, Manuele Biazzo, Baptiste Mateu, Raimondo Di Liello, Bruno Daniele, Nicola Normanno, Antonella De Luca, Anna Maria Rachiglio, Carmela Chiaramonte, Francesca Maria Giugliano, Lorenzo Chiariotti, Giuseppe Catapano, Lorena Coretti, Francesca Lembo
Publikováno v:
Frontiers in Oncology, Vol 14 (2024)
Oncotherapy can shape intestinal microbiota, which, in turn, may influence therapy effectiveness. Furthermore, microbiome signatures during treatments can be leveraged for the development of personalised therapeutic protocols in cancer treatment base
Externí odkaz:
https://doaj.org/article/498ddb15630d43ecad9d6da11908f2b2
Autor:
Piergiuseppe Colombo, Giuseppina Adriana Buonamassa, Anita Giulianini, Letizia Hassan, Noemi Rudini, Antonio Rizzo, Enrico Cavallo, Carlo Carnaghi, Salumeh Goudarzi, Sebastiano Mongiovì, Sarah Pafumi, Stefano Marletta
Publikováno v:
Frontiers in Medicine, Vol 11 (2024)
Neurotrophic tyrosine receptor kinase (NTRK) fusions are infrequent genetic events that can occur in various tumor types. Specifically, NTRK-rearranged sarcoma has been observed in pediatric mesenchymal tumors and, to a lesser extent, in adult mesenc
Externí odkaz:
https://doaj.org/article/d6c4c93b7e1f4b779db9062ffa5215bd
Autor:
Abdul Rehman Syed, Aakash Gorana, Erik Nohr, Xiaoli-Kat Yuan, Parthiv Amin MASc, Sana Ghaznavi, Debbie Lamb, John McIntyre, Markus Eszlinger, Ralf Paschke
Publikováno v:
European Thyroid Journal, Vol 13, Iss 3, Pp 1-10 (2024)
Context: Two-thirds of metastatic differentiated thyroid cancer (DTC) patients have radioiodine (RAI)-resistant disease, resulting in poor prognosis and high mortality. For rare NTRK and RET fusion-positive metastatic, RAI-resistant thyroid cancers,
Externí odkaz:
https://doaj.org/article/38d26f050f294e1ea4ce0ff73d3443c5
Autor:
Wei Zhang, Arndt A. Schmitz, Roosa E. Kallionpää, Merja Perälä, Niina Pitkänen, Mikko Tukiainen, Erika Alanne, Korinna Jöhrens, Renate Schulze-Rath, Bahman Farahmand, Jihong Zong
Publikováno v:
Acta Oncologica, Vol 63, Iss 1 (2024)
Background: Neurotrophic tyrosine receptor kinase (NTRK) gene fusions are oncogenic drivers. Using the Auria Biobank in Finland, we aimed to identify and characterize patients with these gene fusions, and describe their clinical and tumor characteris
Externí odkaz:
https://doaj.org/article/e095f9124f444d38a0377cda8832f56f
Autor:
Philippe Metellus, Clara Camilla, Emilie Bialecki, Nathalie Beaufils, Christine Vellutini, Eric Pellegrino, Pascale Tomasini, Manmeet S. Ahluwalia, Alireza Mansouri, Isabelle Nanni, L’Houcine Ouafik
Publikováno v:
Frontiers in Oncology, Vol 14 (2024)
BackgroundOncogenic fusions of neurotrophic receptor tyrosine kinase NTRK1, NTRK2, or NTRK3 genes have been found in different types of solid tumors. The treatment of patients with TRK fusion cancer with a first-generation TRK inhibitor (such as laro
Externí odkaz:
https://doaj.org/article/ed3fc3c4abd840519e77be3825438190
Autor:
Yasuhiro Kato, Masaru Matsumoto, Natsuki Takano, Mariko Hirao, Kuniko Matsuda, Takehiro Tozuka, Naomi Onda, Shinji Nakamichi, Susumu Takeuchi, Akihiko Miyanaga, Rintaro Noro, Akihiko Gemma, Masahiro Seike
Publikováno v:
Cancer Medicine, Vol 13, Iss 12, Pp n/a-n/a (2024)
Abstract Introduction A neurotrophic tropomyosin receptor kinase (NTRK)‐tyrosine kinase inhibitor (TKI) has shown dramatic efficacy against malignant tumors harboring an NTRK fusion gene. However, almost all tumors eventually acquire resistance to
Externí odkaz:
https://doaj.org/article/7e17ba81b3294778a9a44409ba4acb39
Publikováno v:
Cancer Medicine, Vol 13, Iss 12, Pp n/a-n/a (2024)
Abstract Background Members of the neurotrophic tropomyosin receptor kinase (NTRK) gene family, NTRK1, NTRK2, and NTRK3 encode TRK receptor tyrosine kinases. Intra‐ or inter‐chromosomal gene rearrangements produce NTRK gene fusions encoding fusio
Externí odkaz:
https://doaj.org/article/0c4e6c216d3d4e609290f7e2ce658c5f
Autor:
Federica Zito Marino, Simona Buono, Marco Montella, Rosa Giannatiempo, Francesco Messina, Giovanni Casaretta, Grazia Arpino, Giulia Vita, Francesco Fiorentino, Luigi Insabato, Alessandro Sgambato, Michele Orditura, Renato Franco, Marina Accardo
Publikováno v:
The Journal of Pathology: Clinical Research, Vol 9, Iss 5, Pp 367-377 (2023)
Abstract Triple‐negative breast cancer (TNBC) is usually an aggressive disease with a poor prognosis and limited treatment options. The neurotrophic tyrosine receptor kinase (NTRK) gene fusions are cancer type‐agnostic emerging biomarkers approve
Externí odkaz:
https://doaj.org/article/92e0f09f3c1947ca80404c43828e4f6a