Anti-oxidative or anti-inflammatory additives reduce ischemia/reperfusions injury in an animal model of cardiopulmonary bypass

Autor: Johannes Seeger, Marie Mewes, Sophie Sigusch, Aida Salameh, Ingo Dähnert, Marcel Vollroth, Stefan Dhein, Philipp Kiefer

Publikováno v: Saudi Journal of Biological Sciences, Vol 27, Iss 1, Pp 18-29 (2020)
Saudi Journal of Biological Sciences

Severe inborn cardiac malformations are typically corrected in cardioplegia, with a cardio-pulmonary bypass (CPB) taking over body circulation. During the operation the arrested hearts are subjected to a global ischemia/reperfusion injury. Although t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5d5365bb8c01902b28b5ec20940c25b5
https://doi.org/10.1016/j.sjbs.2019.04.003

Nitrosative Stress as a Modulator of Inflammatory Change in a Model of Takotsubo Syndrome

Autor: Irene Stafford, Sujith Chacko, B. Raman, Matthew Chapman, Giovanni Licari, John D. Horowitz, Michael P. Frenneaux, Sven Y. Surikow, Thanh H Nguyen, Doan T.M. Ngo, S. Chua, Yuan Zhang, Darren J. Kelly, Mark T. Waddingham, Alexander P. Bate, Kuljit Singh

Publikováno v: JACC: Basic to Translational Science, Vol 3, Iss 2, Pp 213-226 (2018)
JACC: Basic to Translational Science

Visual Abstract
Highlights • Treatment of female rats with a single dose of isoproterenol results in apical hypokinesis mimicking Takotsubo syndrome • Myocardial inflammation includes increased content of 3-nitrotyrosine and poly(ADP-ribose)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fd4c32154691c8d7399aa8085eaf9589
http://www.sciencedirect.com/science/article/pii/S2452302X17302644

The synthetic triterpenoid RTA dh404 (CDDO-dhTFEA) restores endothelial function impaired by reduced Nrf2 activity in chronic kidney disease

Autor: Stan Shelkovnikov, Colin J. Meyer, Mohammad A. Aminzadeh, Nosratola D. Vaziri, Scott A. Reisman, Mahyar Khazaeli, Seyed H. Farzaneh

Publikováno v: Redox Biology
Redox biology, vol 1, iss 1
Aminzadeh, MA; Reisman, SA; Vaziri, ND; Shelkovnikov, S; Farzaneh, SH; Khazaeli, M; et al.(2013). The synthetic triterpenoid RTA dh404 (CDDO-dhTFEA) restores endothelial function impaired by reduced Nrf2 activity in chronic kidney disease. Redox Biology, 1(1), 527-531. doi: 10.1016/j.redox.2013.10.007. UC Irvine: Retrieved from: http://www.escholarship.org/uc/item/17q0p1dp
Redox Biology, Vol 1, Iss 1, Pp 527-531 (2013)

Chronic kidney disease (CKD) is associated with endothelial dysfunction and accelerated cardiovascular disease, which are largely driven by systemic oxidative stress and inflammation. Oxidative stress and inflammation in CKD are associated with and,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::060c853105bbaab928964d655e6ef136

Nitrosative Stress as a Modulator of Inflammatory Change in a Model of Takotsubo Syndrome.

Autor: Surikow SY; The Queen Elizabeth Hospital, Department of Cardiology, University of Adelaide, South Australia, Australia.; Basil Hetzel Institute, Adelaide, South Australia, Australia., Nguyen TH; The Queen Elizabeth Hospital, Department of Cardiology, University of Adelaide, South Australia, Australia.; Basil Hetzel Institute, Adelaide, South Australia, Australia., Stafford I; The Queen Elizabeth Hospital, Department of Cardiology, University of Adelaide, South Australia, Australia., Chapman M; The Queen Elizabeth Hospital, Department of Cardiology, University of Adelaide, South Australia, Australia., Chacko S; The Queen Elizabeth Hospital, Department of Cardiology, University of Adelaide, South Australia, Australia., Singh K; The Queen Elizabeth Hospital, Department of Cardiology, University of Adelaide, South Australia, Australia.; Basil Hetzel Institute, Adelaide, South Australia, Australia., Licari G; Basil Hetzel Institute, Adelaide, South Australia, Australia., Raman B; The Queen Elizabeth Hospital, Department of Cardiology, University of Adelaide, South Australia, Australia.; Basil Hetzel Institute, Adelaide, South Australia, Australia., Kelly DJ; Department of Medicine, St. Vincent's Hospital, University of Melbourne, Melbourne, Australia., Zhang Y; Department of Medicine, St. Vincent's Hospital, University of Melbourne, Melbourne, Australia., Waddingham MT; Department of Medicine, St. Vincent's Hospital, University of Melbourne, Melbourne, Australia., Ngo DT; The Queen Elizabeth Hospital, Department of Cardiology, University of Adelaide, South Australia, Australia., Bate AP; The Queen Elizabeth Hospital, Department of Cardiology, University of Adelaide, South Australia, Australia., Chua SJ; The Queen Elizabeth Hospital, Department of Cardiology, University of Adelaide, South Australia, Australia., Frenneaux MP; University of East Anglia, Norfolk, United Kingdom., Horowitz JD; The Queen Elizabeth Hospital, Department of Cardiology, University of Adelaide, South Australia, Australia.; Basil Hetzel Institute, Adelaide, South Australia, Australia.

Publikováno v: JACC. Basic to translational science [JACC Basic Transl Sci] 2018 Apr 18; Vol. 3 (2), pp. 213-226. Date of Electronic Publication: 2018 Apr 18 (Print Publication: 2018).

The synthetic triterpenoid RTA dh404 (CDDO-dhTFEA) restores endothelial function impaired by reduced Nrf2 activity in chronic kidney disease.

Autor: Aminzadeh MA; Division of Nephrology and Hypertension, Schools of Medicine and Biological Science, University of California-Irvine, 101 The City Drive, City Tower, Suite 400, Orange, CA 92868, USA., Reisman SA; Reata Pharmaceuticals, Inc., 2801 Gateway Dr. Ste 150, Irving, TX 75063, USA., Vaziri ND; Division of Nephrology and Hypertension, Schools of Medicine and Biological Science, University of California-Irvine, 101 The City Drive, City Tower, Suite 400, Orange, CA 92868, USA., Shelkovnikov S; Division of Nephrology and Hypertension, Schools of Medicine and Biological Science, University of California-Irvine, 101 The City Drive, City Tower, Suite 400, Orange, CA 92868, USA., Farzaneh SH; Division of Nephrology and Hypertension, Schools of Medicine and Biological Science, University of California-Irvine, 101 The City Drive, City Tower, Suite 400, Orange, CA 92868, USA., Khazaeli M; Division of Nephrology and Hypertension, Schools of Medicine and Biological Science, University of California-Irvine, 101 The City Drive, City Tower, Suite 400, Orange, CA 92868, USA., Meyer CJ; Reata Pharmaceuticals, Inc., 2801 Gateway Dr. Ste 150, Irving, TX 75063, USA.

Publikováno v: Redox biology [Redox Biol] 2013 Oct 31; Vol. 1, pp. 527-31. Date of Electronic Publication: 2013 Oct 31 (Print Publication: 2013).