Zobrazeno 1 - 10
of 249
pro vyhledávání: '"NSD2"'
Autor:
Gerry A. Shipman, Reinnier Padilla, Cynthia Horth, Bo Hu, Eric Bareke, Francisca N. Vitorino, Joanna M. Gongora, Benjamin A. Garcia, Chao Lu, Jacek Majewski
Publikováno v:
Genome Biology, Vol 25, Iss 1, Pp 1-28 (2024)
Abstract Background Methylation of histone 3 lysine 36 (H3K36me) has emerged as an essential epigenetic component for the faithful regulation of gene expression. Despite its importance in development and disease, how the molecular agents collectively
Externí odkaz:
https://doaj.org/article/452dd2d77ae044f69ef58363298ad192
Publikováno v:
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 39, Iss 1 (2024)
AbstractLiver cancer exhibits a high degree of heterogeneity and involves intricate mechanisms. Recent research has revealed the significant role of histone lysine methylation and acetylation in the epigenetic regulation of liver cancer development.
Externí odkaz:
https://doaj.org/article/22b604f5c6384211ba65b8aee18b01df
Akademický článek
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Autor:
Wenxin Feng, Ningning Niu, Ping Lu, Zhuo Chen, Hanyu Rao, Wei Zhang, Chunxiao Ma, Changwei Liu, Yue Xu, Wei‐Qiang Gao, Jing Xue, Li Li
Publikováno v:
Advanced Science, Vol 11, Iss 30, Pp n/a-n/a (2024)
Abstract Pancreatic ductal adenocarcinoma (PDAC) is a clinically challenging cancer with a dismal overall prognosis. NSD2 is an H3K36‐specific di‐methyltransferase that has been reported to play a crucial role in promoting tumorigenesis. Here, th
Externí odkaz:
https://doaj.org/article/5bc7b64706744e498d247e63e96ddbfb
Autor:
Ke Wang, Xiaohong Chen, Peng Lin, Jiao Wu, Qiang Huang, Zhi‐Nan Chen, Jiale Tian, Hao Wang, Ye Tian, Mingyan Shi, Meirui Qian, Bengang Hui, Yumeng Zhu, Ling Li, Rui Yao, Huijie Bian, Ping Zhu, Ruo Chen, Liang Chen
Publikováno v:
Advanced Science, Vol 11, Iss 29, Pp n/a-n/a (2024)
Abstract Immunosuppression is a major hallmark of tumor progression in non‐small cell lung cancer (NSCLC). Cluster of differentiation 147 (CD147), an important pro‐tumorigenic factor, is closely linked to NSCLC immunosuppression. However, the rol
Externí odkaz:
https://doaj.org/article/9d060af812d046ce8d1c05efa275ac99
Akademický článek
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Publikováno v:
Molecular Genetics & Genomic Medicine, Vol 12, Iss 2, Pp n/a-n/a (2024)
Abstract Background Rauch–Steindl syndrome (RAUST) is a very rare genetic syndrome caused by a pathogenic variant in NSD2 on chromosome 4p16.3. Although NSD2 was previously thought to be the major gene in Wolf–Hirschhorn syndrome (WHS), a contigu
Externí odkaz:
https://doaj.org/article/fd6a9b0e24244c0c98e780bcc465462c
Autor:
Shiori Kinoshita, Kazuaki Kojima, Eriko Ohnishi, Yuka Takayama, Hiroki Kikuchi, Shuji Takada, Kazuhiko Nakabayashi, Tomoko Kawai, Kenichiro Hata
Publikováno v:
Frontiers in Genetics, Vol 15 (2024)
Background: Epigenetic disruptions have been implicated in neurodevelopmental disorders. NSD2 is associated with developmental delay/intellectual disability; however, its role in brain development and function remains unclear.Methods: We performed tr
Externí odkaz:
https://doaj.org/article/a55c640feebc490b8dbe57f06ebdad12
Autor:
Jianjian Zhang, Weibin Xie, Bin Ni, Zhuohang Li, Dengyuan Feng, Yao Zhang, Qianguang Han, Hai Zhou, Min Gu, Ruoyun Tan
Publikováno v:
Pharmacological Research, Vol 200, Iss , Pp 107051- (2024)
Renal interstitial fibrosis/tubular atrophy (IF/TA) is a prominent pathological feature of chronic allograft dysfunction (CAD). Our previous study has demonstrated that epithelial-mesenchymal transition (EMT) plays a significant role in shaping the d
Externí odkaz:
https://doaj.org/article/35c74adc66974e878e55487e236914de
Autor:
Sonali Narang, Nikki A. Evensen, Jason Saliba, Joanna Pierro, Mignon L. Loh, Patrick A. Brown, Pandurang Kolekar, Heather Mulder, Ying Shao, John Easton, Xiaotu Ma, Aristotelis Tsirigos, William L. Carroll
Publikováno v:
Genome Biology, Vol 24, Iss 1, Pp 1-25 (2023)
Abstract Background The NSD2 p.E1099K (EK) mutation is shown to be enriched in patients with relapsed acute lymphoblastic leukemia (ALL), indicating a role in clonal evolution and drug resistance. Results To uncover 3D chromatin architecture-related
Externí odkaz:
https://doaj.org/article/2fa3e7fe8efc458a83cdfba95749aef0