In silico analysis of anti-dengue activity of faloak (Sterculia quadrifida R. Br) stem bark compounds

Autor: Audrey G. Riwu, Jusak Nugraha, Djoko A. Purwanto, Erwin A. Triyono

Publikováno v: Journal of Pharmacy & Pharmacognosy Research, Vol 10, Iss 6, Pp 1006-1014 (2022)

Context: Dengue is one of the most common infectious diseases found in tropical and subtropical regions, particularly in urban and semi-urban areas. Management dengue until now has not had a specific therapy. The development of dengue therapy using t

Externí odkaz: https://doaj.org/article/6c11b5f5a81d4e6390fc9d84ff4801cb

Discovery of Bispecific Lead Compounds from Azadirachta indica against ZIKA NS2B-NS3 Protease and NS5 RNA Dependent RNA Polymerase Using Molecular Simulations

Autor: Sanjay Kumar, Sherif A. El-Kafrawy, Shiv Bharadwaj, S. S. Maitra, Thamir A. Alandijany, Arwa A. Faizo, Aiah M. Khateb, Vivek Dhar Dwivedi, Esam I. Azhar

Publikováno v: Molecules, Vol 27, Iss 8, p 2562 (2022)

Zika virus (ZIKV) has been characterized as one of many potential pathogens and placed under future epidemic outbreaks by the WHO. However, a lack of potential therapeutics can result in an uncontrolled pandemic as with other human pandemic viruses.

Externí odkaz: https://doaj.org/article/632b7130ed89491d85e21b3c2e960df6

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Functionalized 2,1-benzothiazine 2,2-dioxides as new inhibitors of Dengue NS5 RNA-dependent RNA polymerase

Autor: Giuseppe Manfroni, Andrea Astolfi, Serena Massari, Stefano Sabatini, Delia Tarantino, Violetta Cecchetti, Gilles Querat, Maria Letizia Barreca, Eloise Mastrangelo, Mario Milani, Rolando Cannalire, Oriana Tabarrini

Publikováno v: European journal of medicinal chemistry (Online) 143 (2018): 1667–1676. doi:10.1016/j.ejmech.2017.10.064
info:cnr-pdr/source/autori:Cannalire R, Tarantino D, Astolfi A, Barreca ML, Sabatini S, Massari S, Tabarrini O, Milani M, Querat G, Mastrangelo E, Manfroni G, Cecchetti V/titolo:Functionalized 2,1-benzothiazine 2,2-dioxides as new inhibitors of Dengue NS5 RNA-dependent RNA polymerase/doi:10.1016%2Fj.ejmech.2017.10.064/rivista:European journal of medicinal chemistry (Online)/anno:2018/pagina_da:1667/pagina_a:1676/intervallo_pagine:1667–1676/volume:143

Over recent years, many RNA viruses have been “re-discovered”, including life-threatening flaviviruses, such as Dengue, Zika, and several encephalitis viruses. Since no specific inhibitors are currently available to treat these infections, there

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c4156ceeaef04b327e11028c150e3873
https://doi.org/10.1016/j.ejmech.2017.10.064