Zobrazeno 1 - 10 of 129 pro vyhledávání: '"NS398"'
1
Akademický článek
The selective cyclooxygenase-2 inhibitor NS398 ameliorates cisplatin-induced impairments in mitochondrial and cognitive function
Autor: Mohammad Abdur Rashid, Jason J. Tang, Ki-Hyun Yoo, Ana Corujo-Ramirez, Alfredo Oliveros, Sang Hoon Kim, Faheem Ullah, Raad Altawell, John R. Hawse, Peter D. Cole, Mi-Hyeon Jang
Publikováno v: Frontiers in Molecular Neuroscience, Vol 16 (2023)
Chemobrain is a condition that negatively affects cognition in cancer patients undergoing active chemotherapy, as well as following chemotherapy cessation. Chemobrain is also known as chemotherapy-induced cognitive impairment (CICI) and has emerged a
Externí odkaz: https://doaj.org/article/2e8a00bc8a824f1c868666a021f4f0a5
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2
Akademický článek
Inhibition of COX-2 ameliorates murine liver schistosomiasis japonica through splenic cellular immunoregulation
Autor: Zhang Qi, Chen Lan, Ji Xiaofang, Tang Juanjuan, Fu Cheng, Huang Ting, Shen Erxia, Li Zi
Publikováno v: Parasites & Vectors, Vol 15, Iss 1, Pp 1-12 (2022)
Abstract Background We have reported the positive association of the cyclooxygenase 2 (COX-2)/prostaglandin E2 (PGE2) axis with liver fibrosis induced by Schistosoma japonicum (Sj) infection, and TLR4 signaling controlled this axis. However, how COX-
Externí odkaz: https://doaj.org/article/4bfb69816939403ab15289fab746bd3d
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3
Akademický článek
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4
Akademický článek
Up-Regulation of Cyclooxygenase-2 (COX-2) Expression by Temozolomide (TMZ) in Human Glioblastoma (GBM) Cell Lines
Autor: Francesca Lombardi, Francesca Rosaria Augello, Serena Artone, Mitilda Karoli Gugu, Maria Grazia Cifone, Benedetta Cinque, Paola Palumbo
Publikováno v: International Journal of Molecular Sciences, Vol 23, Iss 3, p 1545 (2022)
TMZ-resistance remains a main limitation in glioblastoma (GBM) treatment. TMZ is an alkylating agent whose cytotoxicity is modulated by O6-methylguanine-DNA methyltransferase (MGMT), whose expression is determined by MGMT gene promoter methylation st
Externí odkaz: https://doaj.org/article/a89f43dd96284101bb7bc3f013f190e4
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5
Akademický článek
Reduced Susceptibility to Ischemic Brain Injury and N-Methyl-D-Aspartate-Mediated Neurotoxicity in Cyclooxygenase-2-Deficient Mice
Autor: Iadecola, Costantino, Niwa, Kiyoshi, Nogawa, Shigeru, Zhao, Xueren, Nagayama, Masao, Araki, Eiichi, Morham, Scott, Ross, M. Elizabeth
Publikováno v: Proceedings of the National Academy of Sciences of the United States of America, 2001 Jan . 98(3), 1294-1299.
Externí odkaz: https://www.jstor.org/stable/3054861
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6
Cyclooxygenase-2 Upregulated by Temozolomide in Glioblastoma Cells Is Shuttled In Extracellular Vesicles Modifying Recipient Cell Phenotype
Autor: Francesca Lombardi, Francesca Rosaria Augello, Serena Artone, Emira Ayroldi, Ilaria Giusti, Vincenza Dolo, Maria Grazia Cifone, Benedetta Cinque, Paola Palumbo
Publikováno v: Frontiers in oncology. 12
Temozolomide (TMZ) resistance is frequent in patients with glioblastoma (GBM), a tumor characterized by a marked inflammatory microenvironment. Recently, we reported that cyclooxygenase-2 (COX-2) is upregulated in TMZ-resistant GBM cells treated with
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ff08723901f538b4e625291e8e4edc86
https://pubmed.ncbi.nlm.nih.gov/35936755
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7
Akademický článek
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8
Akademický článek
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9
Biological effects of selective COX-2 inhibitor NS398 on human glioblastoma cell lines
Autor: Vincenza Dolo, Benedetta Cinque, Maria Grazia Cifone, Paola Palumbo, Francesca Lombardi, Pietro Leocata, Ilaria Giusti, Francesca Rosaria Augello
Publikováno v: Cancer Cell International
Cancer Cell International, Vol 20, Iss 1, Pp 1-17 (2020)
Background Cyclooxygenase-2 (COX-2), an inflammation-associated enzyme, has been implicated in tumorigenesis and progression of glioblastoma (GBM). The poor survival of GBM was mainly associated with the presence of glioma stem cells (GSC) and the ma
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::131968760527432c435438f9442ac5d4
https://pubmed.ncbi.nlm.nih.gov/32435158
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10
NS398 as a potential drug for autosomal-dominant polycystic kidney disease: Analysis using bioinformatics, and zebrafish and mouse models
Autor: Shoulian Zhou, Lili Fu, Sixiu Chen, Bo Yang, Linxi Huang, Qingzhou Zhang, Changlin Mei, Dechao Xu, Mengna Ruan, Zhiguo Mao
Publikováno v: Journal of Cellular and Molecular Medicine
Autosomal‐dominant polycystic kidney disease (ADPKD) is characterized by uncontrolled renal cyst formation, and few treatment options are available. There are many parallels between ADPKD and clear‐cell renal cell carcinoma (ccRCC); however, few
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c3996eafac0164a75ef5fe31d7ae8ea1
https://pubmed.ncbi.nlm.nih.gov/34551202
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