Mining the Plasma Proteome for Insights into the Molecular Pathology of Pulmonary Arterial Hypertension

Autor: Lars Harbaum, Christopher J. Rhodes, John Wharton, Allan Lawrie, Jason H. Karnes, Ankit A. Desai, William C. Nichols, Marc Humbert, David Montani, Barbara Girerd, Olivier Sitbon, Mario Boehm, Tatyana Novoyatleva, Ralph T. Schermuly, H. Ardeschir Ghofrani, Mark Toshner, David G. Kiely, Luke S. Howard, Emilia M. Swietlik, Stefan Gräf, Maik Pietzner, Nicholas W. Morrell, Martin R. Wilkins, L Southgate, RD Machado, J Martin, WH Ouwehand, MW Pauciulo, A Arora, K Lutz, F Ahmad, SL Archer, R Argula, ED Austin, D Badesch, S Bakshi, C Barnett, R Benza, N Bhatt, CD Burger, M Chakinala, J Elwing, T Fortin, RP Frantz, A Frost, JGN Garcia, J Harley, H He, NS Hill, R Hirsch, D Ivy, J Klinger, T Lahm, K Marsolo, LJ Martin, SD Nathan, RJ Oudiz, Z Rehman, I Robbins, DM Roden, EB Rosenzweig, G Saydain, R Schilz, RW Simms, M Simon, H Tang, AY Tchourbanov, T Thenappan, F Torres, AK Walsworth, RE Walter, RJ White, J Wilt, D Yung, R Kittles, J Aman, J Knight, KB Hanscombe, H Gall, A Ulrich, HJ Bogaard, C Church, JG Coghlan, R Condliffe, PA Corris, C Danesino, CG Elliott, A Franke, S Ghio, JSR Gibbs, AC Houweling, G Kovacs, M Laudes, RV MacKenzie Ross, S Moledina, M Newnham, A Olschewski, H Olschewski, AJ Peacock, J Pepke-Zaba, L Scelsi, W Seeger, CM Shaffer, O Sitbon, J Suntharalingam, C Treacy, A Vonk Noordegraaf, Q Waisfisz, SJ Wort, RC Trembath, M Germain, I Cebola, J Ferrer, P Amouyel, S Debette, M Eyries, F Soubrier, DA Trégouët

Rationale: Pulmonary arterial hypertension (PAH) is characterized by structural remodeling of pulmonary arteries and arterioles. Underlying biological processes are likely reflected in a perturbation of circulating proteins. Objectives: To quantify a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f363dc083e705c01eb9c6d70a4b67afd
https://www.repository.cam.ac.uk/handle/1810/340465

Frequency of Screening and Spontaneous Breathing Trial Techniques: A Randomized Clinical Trial.

Autor: Burns KEA; Interdepartmental Division of Critical Care, University of Toronto, Toronto, Ontario, Canada.; Department of Critical Care, Unity Health Toronto-St Michael's Hospital, Toronto, Ontario, Canada.; Applied Health Research Centre, Li Ka Shing Knowledge Institute, Unity Health Toronto-St Michael's Hospital, Toronto, Ontario, Canada.; Department of Health Research Methods, Evidence, and Impact, Faculty of Health Sciences, McMaster University, Hamilton, Ontario, Canada., Wong J; University of Toronto, Temerty Faculty of Medicine, Toronto, Ontario, Canada., Rizvi L; Department of Critical Care, Unity Health Toronto-St Michael's Hospital, Toronto, Ontario, Canada., Lafreniere-Roula M; Applied Health Research Centre, Li Ka Shing Knowledge Institute, Unity Health Toronto-St Michael's Hospital, Toronto, Ontario, Canada., Thorpe K; Applied Health Research Centre, Li Ka Shing Knowledge Institute, Unity Health Toronto-St Michael's Hospital, Toronto, Ontario, Canada.; University of Toronto, Dalla Lana School of Public Health, Toronto, Ontario, Canada., Devlin JW; Bouve College of Health Sciences, Northeastern University, Boston, Massachusetts.; Division of Pulmonary and Critical Care Medicine, Brigham and Women's Hospital, Boston, Massachusetts., Cook DJ; Department of Health Research Methods, Evidence, and Impact, Faculty of Health Sciences, McMaster University, Hamilton, Ontario, Canada.; Departments of Medicine and Anesthesia, Faculty of Health Sciences, McMaster University, Hamilton, Ontario, Canada., Seely A; Department of Critical Care, Ottawa Hospital, Ottawa, Ontario, Canada.; Division of Thoracic Surgery, Department of Surgery and Ottawa Hospital Research Institute, University of Ottawa, Ottawa, Ontario, Canada., Dodek PM; Division of Critical Care Medicine and Center for Advancing Health Outcomes, St Paul's Hospital, Vancouver, British Columbia, Canada.; University of British Columbia, Vancouver, Canada., Tanios M; Division of Pulmonary and Critical Care Medicine, University of California, Irvine.; Pulmonary and Critical Care, Memorial Care, Long Beach Medical Center, Long Beach, California., Piraino T; Department of Critical Care, Unity Health Toronto-St Michael's Hospital, Toronto, Ontario, Canada.; Departments of Medicine and Anesthesia, Faculty of Health Sciences, McMaster University, Hamilton, Ontario, Canada., Gouskos A; Patient and Family Advisory Committee of the Frequency of Screening and Spontaneous Breathing Trial Technique Trial, Unity Health Toronto-St Michael's Hospital, Toronto, Ontario, Canada., Kiedrowski KC; Patient and Family Advisory Committee of the Frequency of Screening and Spontaneous Breathing Trial Technique Trial, Unity Health Toronto-St Michael's Hospital, Toronto, Ontario, Canada., Kay P; Patient and Family Advisory Committee of the Frequency of Screening and Spontaneous Breathing Trial Technique Trial, Unity Health Toronto-St Michael's Hospital, Toronto, Ontario, Canada., Mitchell S; Patient and Family Advisory Committee of the Frequency of Screening and Spontaneous Breathing Trial Technique Trial, Unity Health Toronto-St Michael's Hospital, Toronto, Ontario, Canada., Merner GW; Patient and Family Advisory Committee of the Frequency of Screening and Spontaneous Breathing Trial Technique Trial, Unity Health Toronto-St Michael's Hospital, Toronto, Ontario, Canada., Mayette M; Departments of Medicine and Anesthesia, Université de Sherbrooke, Sherbrooke, Quebec, Canada.; Centre de Recherche du Centre Hospitalier Universitaire de Sherbrooke, Sherbrooke, Quebec, Canada., D'Aragon F; Departments of Medicine and Anesthesia, Université de Sherbrooke, Sherbrooke, Quebec, Canada.; Centre de Recherche du Centre Hospitalier Universitaire de Sherbrooke, Sherbrooke, Quebec, Canada., Lamontagne F; Departments of Medicine and Anesthesia, Université de Sherbrooke, Sherbrooke, Quebec, Canada.; Centre de Recherche du Centre Hospitalier Universitaire de Sherbrooke, Sherbrooke, Quebec, Canada., Rochwerg B; Department of Health Research Methods, Evidence, and Impact, Faculty of Health Sciences, McMaster University, Hamilton, Ontario, Canada.; Departments of Medicine and Anesthesia, Faculty of Health Sciences, McMaster University, Hamilton, Ontario, Canada., Turgeon A; Department of Anesthesiology and Critical Care Medicine, Faculty of Medicine, Université Laval, Quebec, Quebec, Canada.; Population Health and Optimal Health Practice Research Unit, Centre Hospitalier Universitaire de Québec-Université Laval Research Center, Quebec, Quebec, Canada., Sia YT; Department of Medicine, Centre Intégré Universitaire en Santé et Services Sociaux Rivières de la Mauricie-et-du-Centre-du Québec, Trois-Rivières, Quebec, Canada., Charbonney E; Department of Medicine, University of Montreal, Montreal, Quebec, Canada.; Centre Hospitalier de l'Université de Montréal, Montreal, Quebec, Canada., Aslanian P; Department of Medicine, University of Montreal, Montreal, Quebec, Canada.; Centre Hospitalier de l'Université de Montréal, Montreal, Quebec, Canada., Criner GJ; Department of Thoracic Medicine and Surgery, Lewis Katz School of Medicine, Temple University, Philadelphia, Pennsylvania., Hyzy RC; Division of Pulmonary and Critical Care Medicine, Department of Medicine; University of Michigan, Ann Arbor., Beitler JR; Center for Acute Respiratory Failure and Department of Internal Medicine, Columbia University, New York, New York., Kassis EB; School of Medicine, Harvard University, Boston, Massachusetts.; Division of Pulmonary and Critical Care, Beth Israel Deaconess Medical Center, Boston, Massachusetts., Kutsogiannis DJ; Department of Critical Care Medicine, Faculty of Medicine and Dentistry, University of Alberta, Edmonton, Canada., Meade MO; Department of Health Research Methods, Evidence, and Impact, Faculty of Health Sciences, McMaster University, Hamilton, Ontario, Canada.; Departments of Medicine and Anesthesia, Faculty of Health Sciences, McMaster University, Hamilton, Ontario, Canada.; Department of Critical Care, Hamilton Health Sciences, Hamilton, Ontario, Canada., Liebler J; Division of Pulmonary, Critical Care and Medicine, Keck School of Medicine, University of Southern California, Los Angeles., Iyer-Kumar S; Division of Pulmonary, Critical Care and Medicine, Keck School of Medicine, University of Southern California, Los Angeles., Tsang J; Departments of Medicine and Anesthesia, Faculty of Health Sciences, McMaster University, Hamilton, Ontario, Canada.; Niagara Health Knowledge Institute, Niagara Health, St Catharines, Ontario, Canada., Cirone R; Divisions of Critical Care and Anesthesia, Unity Health Toronto-St Joseph's Hospital, Toronto, Ontario, Canada., Shanholtz C; Department of Medicine and Division of Pulmonary and Critical Care Medicine, School of Medicine, University of Maryland, Baltimore., Hill NS; Division of Pulmonary, Critical Care and Sleep Medicine, Tufts Medical Center, Boston, Massachusetts.

Publikováno v: JAMA [JAMA] 2024 Dec 03; Vol. 332 (21), pp. 1808-1821.

How to prevent postextubation respiratory failure.

Autor: Hernández G; Toledo University Hospital, Toledo.; Ciber Enfermedades Respiratorias (CIBERES), Health Institute Carlos III.; Grupo de Investigación en Disfunción y Fallo Orgánico en la Agresión (IdiPAZ).; Universidad Alfonso X el Sabio, Madrid, Spain., Hill NS; Division of Pulmonary, Critical Care and Sleep Medicine, Tufts University School of Medicine, Boston, Massachusetts, USA.

Publikováno v: Current opinion in critical care [Curr Opin Crit Care] 2024 Nov 05. Date of Electronic Publication: 2024 Nov 05.

Association of Male Sex With Worse Right Ventricular Function and Survival in Pulmonary Hypertension in the Redefining Pulmonary Hypertension Through Pulmonary Vascular Disease Phenomics Cohort.

Autor: Shelburne NJ; Division of Allergy, Pulmonary and Critical Care Medicine, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN; INTEGRIS Advanced Cardiopulmonary Care, INTEGRIS Baptist Medical Center, Oklahoma City, OK., Nian H; Department of Biostatistics, Vanderbilt University Medical Center, Nashville, TN., Beck GJ; Department of Quantitative Health Sciences, Cleveland Clinic, Cleveland., Casanova NG; Division of Pulmonary, Allergy, Critical Care and Sleep Medicine, Department of Medicine, University of Arizona, Tucson, AZ., Desai AA; Department of Medicine, Indiana University, Indianapolis, IN., DuBrock HM; Division of Pulmonary and Critical Care Medicine, Mayo Clinic, Rochester, MN., Erzurum S; Lerner Research Institute, Cleveland Clinic, Cleveland; Respiratory Institute, Cleveland Clinic, Cleveland., Frantz RP; Department of Internal Medicine, the Department of Cardiovascular Diseases, Mayo Clinic, Rochester, MN., Hassoun PM; Division of Pulmonary and Critical Care Medicine, Department of Medicine, Johns Hopkins University, Baltimore., Hill NS; Division of Pulmonary, Critical Care, and Sleep Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA., Horn EM; Division of Cardiology, Department of Pediatrics and Medicine, Columbia University Medical Center-New York Presbyterian Hospital., Jacob MS; Department of Cardiovascular Medicine, Cleveland Clinic, Cleveland., Jellis CL; Department of Cardiovascular Medicine, Cleveland Clinic, Cleveland., Joseloff E; Pulmonary Hypertension Association, Silver Spring, MD., Kwon DH; Department of Cardiovascular Medicine, Cleveland Clinic, Cleveland., Brett Larive A; Department of Quantitative Health Sciences, Cleveland Clinic, Cleveland., Leopold JA; Tufts Medical Center, Division of Cardiovascular Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA., Park MM; Department of Cardiovascular Medicine, Cleveland Clinic, Cleveland., Rischard FP; Division of Pulmonary, Allergy, Critical Care and Sleep Medicine, Department of Medicine, University of Arizona, Tucson, AZ., Rosenzweig EB; Perkin Heart Failure Center, Weill Cornell Medical Center, the Division of Pediatric Cardiology, Department of Pediatrics and Medicine, Columbia University Medical Center-New York Presbyterian Hospital., Vanderpool RR; Division of Cardiovascular Medicine, Department of Internal Medicine, The Ohio State University, Columbus, OH., Yu C; Department of Population Health, NYU Grossman School of Medicine, New York, NY., Hemnes AR; Division of Allergy, Pulmonary and Critical Care Medicine, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN.

Publikováno v: CHEST pulmonary [CHEST Pulm] 2024 Sep; Vol. 2 (3). Date of Electronic Publication: 2024 Mar 11.

Simultaneous Positron Emission Tomography and Molecular Magnetic Resonance Imaging of Cardiopulmonary Fibrosis in a Mouse Model of Left Ventricular Dysfunction.

Autor: Moon BF; Department of Radiology, Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital and Harvard Medical School Boston MA USA.; Institute for Innovation in Imaging, Massachusetts General Hospital Boston MA USA., Zhou IY; Department of Radiology, Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital and Harvard Medical School Boston MA USA.; Institute for Innovation in Imaging, Massachusetts General Hospital Boston MA USA., Ning Y; Department of Radiology, Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital and Harvard Medical School Boston MA USA.; Institute for Innovation in Imaging, Massachusetts General Hospital Boston MA USA., Chen YI; Department of Radiology, Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital and Harvard Medical School Boston MA USA., Le Fur M; Department of Radiology, Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital and Harvard Medical School Boston MA USA.; Institute for Innovation in Imaging, Massachusetts General Hospital Boston MA USA., Shuvaev S; Department of Radiology, Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital and Harvard Medical School Boston MA USA.; Institute for Innovation in Imaging, Massachusetts General Hospital Boston MA USA., Akam EA; Department of Medicine, Division of Cardiology, Massachusetts General Hospital and Harvard Medical School Boston MA USA., Ma H; Department of Radiology, Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital and Harvard Medical School Boston MA USA.; Institute for Innovation in Imaging, Massachusetts General Hospital Boston MA USA., Solsona CM; Bruker BioSpin, Preclinical Imaging Billerica MA USA., Weigand-Whittier J; Department of Radiology, Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital and Harvard Medical School Boston MA USA., Rotile N; Department of Radiology, Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital and Harvard Medical School Boston MA USA.; Institute for Innovation in Imaging, Massachusetts General Hospital Boston MA USA., Hariri LP; Department of Medicine, Division of Pulmonary and Critical Care Medicine, Massachusetts General Hospital and Harvard Medical School Boston MA USA.; Department of Pathology, Massachusetts General Hospital, Harvard Medical School Boston MA USA., Drummond M; Department of Medicine, Division of Pulmonary and Critical Care Medicine, Massachusetts General Hospital and Harvard Medical School Boston MA USA., Boice AT; Department of Radiology, Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital and Harvard Medical School Boston MA USA.; Institute for Innovation in Imaging, Massachusetts General Hospital Boston MA USA., Zygmont SE; Department of Radiology, Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital and Harvard Medical School Boston MA USA.; Institute for Innovation in Imaging, Massachusetts General Hospital Boston MA USA., Sharma Y; Pulmonary, Critical Care and Sleep Medicine, Tufts Medical Center Boston MA USA., Warburton RR; Pulmonary, Critical Care and Sleep Medicine, Tufts Medical Center Boston MA USA., Martin GL; Molecular Cardiology Research Institute, Tufts Medical Center Boston MA USA., Blanton RM; Molecular Cardiology Research Institute, Tufts Medical Center Boston MA USA., Fanburg BL; Pulmonary, Critical Care and Sleep Medicine, Tufts Medical Center Boston MA USA., Hill NS; Pulmonary, Critical Care and Sleep Medicine, Tufts Medical Center Boston MA USA., Caravan P; Department of Radiology, Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital and Harvard Medical School Boston MA USA.; Institute for Innovation in Imaging, Massachusetts General Hospital Boston MA USA., Penumatsa KC; Pulmonary, Critical Care and Sleep Medicine, Tufts Medical Center Boston MA USA.

Publikováno v: Journal of the American Heart Association [J Am Heart Assoc] 2024 Jul 16; Vol. 13 (14), pp. e034363. Date of Electronic Publication: 2024 Jul 09.