Astrocytic transcription factor REST upregulates glutamate transporter EAAT2, protecting dopaminergic neurons from manganese-induced excitotoxicity

Autor: Michael Aschner, Karam F.A. Soliman, Eun Sook Lee, Deok-Soo Son, Ivan Nyarko-Danquah, Alexis Digman, Edward Alain B. Pajarillo

Publikováno v: The Journal of Biological Chemistry

Chronic exposure to high levels of manganese (Mn) leads to manganism, a neurological disorder with similar symptoms to those inherent to Parkinson's disease. However, the underlying mechanisms of this pathological condition have yet to be established

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bb027f882dbfb30f4fe78b25a2cf0a52
https://doi.org/10.1016/j.jbc.2021.101372

Porcine synapsin 1: SYN1 gene analysis and functional characterization of the promoter

Autor: Christian Bendixen, Jamal Momeni, Claus Hedegaard, Claus Oxvig, Carina Henriksen, Lone Bruhn Madsen, Knud Larsen, Kasper Kjaer-Sorensen

Publikováno v: Hedegaard, C, Kjaer-Sorensen, K, Madsen, L B, Henriksen, C, Momeni, J, Bendixen, C, Oxvig, C & Larsen, K E 2013, ' Porcine synapsin 1: SYN1 gene analysis and functional characterization of the promoter ', F E B S Open Bio, vol. 3, pp. 411–420 . https://doi.org/10.1016/j.fob.2013.10.002
FEBS Open Bio

Synapsin 1 (SYN1) is a phosphoprotein involved in nerve signal transmission. The porcine SYN1 promoter orthologue was cloned and characterized to provide a means of expressing a transgene specifically in neurons. The nucleotide sequence of the promot

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e782a2381a7687c297f7288ad6a2fc65
https://pure.au.dk/portal/da/publications/porcine-synapsin-1-syn1-gene-analysis-and-functional-characterization-of-the-promoter(3b99a1ce-2c92-46b9-95ee-cae8e000108f).html

Regulation of GluR2 promoter activity by neurotrophic factors via a neuron-restrictive silencer element.

Autor: Brené, Stefan^1,2 (AUTHOR), Messer, Chad² (AUTHOR), Okado, Haruo³ (AUTHOR), Hartley, Melissa³ (AUTHOR), Heinemann, Stephen F.³ (AUTHOR), Nestler, Eric J.² (AUTHOR)

Publikováno v: European Journal of Neuroscience. May2000, Vol. 12 Issue 5, p1525-1533. 9p. 1 Chart.

NRSF regulates age-dependently cognitive ability and its conditional knockout in APP/PS1 mice moderately alters AD-like pathology.

Autor: Yang, Yufang, Zhang, Xiaoshuang, Li, Dongxue, Fang, Rong, Wang, Zishan, Yun, Di, Wang, Mo, Wang, Jinghui, Dong, Hongtian, Fei, Zhaoliang, Li, Qing, Liu, Zhaolin, Shen, Chenye, Fei, Jian, Yu, Mei, Behnisch, Thomas, Huang, Fang

Publikováno v: Human Molecular Genetics; 8/15/2023, Vol. 32 Issue 16, p2558-2575, 18p

NRSF/REST-Mediated Epigenomic Regulation in the Heart: Transcriptional Control of Natriuretic Peptides and Beyond.

Autor: Inazumi, Hideaki, Kuwahara, Koichiro

Publikováno v: Biology (2079-7737); Aug2022, Vol. 11 Issue 8, pN.PAG-N.PAG, 13p