Zobrazeno 1 - 10
of 510
pro vyhledávání: '"NR4A2"'
Autor:
Ryota TERASHIMA, Daiki NAGAO, Masato IKEO, Keisuke MORIOKA, Titaree LAOHARATCHATATHANIN, Shiro KURUSU, Mitsumori KAWAMINAMI
Publikováno v:
The Journal of Reproduction and Development, Vol 70, Iss 2, Pp 115-122 (2024)
The NR4A nuclear receptor family (NR4As), encompassing NR4A1, NR4A2, and NR4A3, exerts pivotal roles in cellular processes through intricate expression patterns and interactions. Despite the influence of some NR4As on anterior pituitary functions reg
Externí odkaz:
https://doaj.org/article/2586248e326f41b39f11280845db9610
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 10, p 5198 (2024)
The NR4A2 gene encodes an orphan transcription factor of the steroid–thyroid hormone–retinoid receptor superfamily. This review focuses on the clinical findings associated with the pathogenic variants so far reported, including three unreported c
Externí odkaz:
https://doaj.org/article/01f22c8a10394aacab5c9694b1a71199
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 6, p 3305 (2024)
Cardiomyocyte survival is a critical contributing process of host adaptive responses to cardiovascular diseases (CVD). Cells of the cardiovascular endothelium have recently been reported to promote cardiomyocyte survival through exosome-loading cargo
Externí odkaz:
https://doaj.org/article/02839c5e179047ec90b33016b2999759
Autor:
David E. Phelan, Ben Reddan, Masahiko Shigemura, Jacob I. Sznajder, Daniel Crean, Eoin P. Cummins
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 5, p 2852 (2024)
Hypercapnia occurs when the partial pressure of carbon dioxide (CO2) in the blood exceeds 45 mmHg. Hypercapnia is associated with several lung pathologies and is transcriptionally linked to suppression of immune and inflammatory signalling through po
Externí odkaz:
https://doaj.org/article/a538e415c47d4983ab84f11c5a7733b9
Autor:
Srijana Upadhyay, Amanuel Esayas Hailemariam, Fuada Mariyam, Zahin Hafiz, Gregory Martin, Jainish Kothari, Evan Farkas, Gargi Sivaram, Logan Bell, Ronald Tjalkens, Stephen Safe
Publikováno v:
Biomolecules, Vol 14, Iss 3, p 284 (2024)
Bis-indole derived compounds such as 1,1-bis(3′-indolyl)-1-(3,5-disubstitutedphenyl) methane (DIM-3,5) and the corresponding 4-hydroxyl analogs (DIM8-3,5) are NR4A1 ligands that act as inverse NR4A1 agonists and are potent inhibitors of tumor growt
Externí odkaz:
https://doaj.org/article/c600864d081d4f5ba321b97daaa1bfef
Autor:
Wenbin Liu, Yue Zhao, Junyan Fan, Jiaying Shen, Hailin Tang, Wanda Tang, Di Wu, Weijin Huang, Yibo Ding, Peng Qiao, Jiansheng Lin, Zishuai Li, Qianqian Li, Qianqian Cui, Yan Liu, Yifan Chen, Rui Pu, Xue Han, Jianhua Yin, Xiaojie Tan, Guangwen Cao
Publikováno v:
Advanced Science, Vol 10, Iss 26, Pp n/a-n/a (2023)
Abstract Cigarette smoke aggravates severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) infection. However, the underlying mechanisms remain unclear. Here, they show that benzo[a]pyrene in cigarette smoke extract facilitates SARS‐CoV
Externí odkaz:
https://doaj.org/article/9598c1584d22471281f5dc550319225e
Autor:
Yong He, Yue Wang, Heming Yu, Yu Tian, Xiangyu Chen, Chong Chen, Yikun Ren, Zhi Chen, Yi Ren, Xue Gong, Ke Cheng, Xiaolei Liu, Lianmei Zhong, Yi Guo, Peng Xie
Publikováno v:
Pharmacological Research, Vol 191, Iss , Pp 106717- (2023)
Neuroinflammation is tightly associated with onset of depression. The nuclear receptor related 1 protein (Nurr1, also called Nr4a2), its roles in dopaminergic neurons is well understood, which can alleviate inflammation. Nevertheless, potential effec
Externí odkaz:
https://doaj.org/article/c57628bcb9854c7abc20c23655cd3b7f
Autor:
Hiroko Shiraki, Shigeru Tanaka, Yun Guo, Kana Harada, Izumi Hide, Tomoharu Yasuda, Norio Sakai
Publikováno v:
Journal of Pharmacological Sciences, Vol 148, Iss 3, Pp 307-314 (2022)
G protein-coupled receptor 3 (GPR3) constitutively activates Gαs proteins without any ligands and is predominantly expressed in neurons. Since the expression and physiological role of GPR3 in immune cells is still unknown, we examined the possible r
Externí odkaz:
https://doaj.org/article/404c9a5e05b5429a86af4e272363a08c
Publikováno v:
Current Research in Immunology, Vol 3, Iss , Pp 23-36 (2022)
The myeloid cellular compartment comprises monocytes, dendritic cells (DCs), macrophages and granulocytes. As diverse as this group of cells may be, they are all an important part of the innate immune system and are therefore linked by the necessity
Externí odkaz:
https://doaj.org/article/439f823f70ca46ce8a110d805abb2789
Autor:
Elizabeth Ruiz-Sánchez, Janet Jiménez-Genchi, Yessica M. Alcántara-Flores, Carlos J. Castañeda-González, Carlos L. Aviña-Cervantes, Petra Yescas, María del Socorro González-Valadez, Nancy Martínez-Rodríguez, Antonio Ríos-Ortiz, Martha González-González, María E. López-Navarro, Patricia Rojas
Publikováno v:
BMC Psychiatry, Vol 21, Iss 1, Pp 1-13 (2021)
Abstract Background Cognitive functions represent useful endophenotypes to identify the association between genetic variants and schizophrenia. In this sense, the NR4A2 gene has been implicated in schizophrenia and cognition in different animal model
Externí odkaz:
https://doaj.org/article/1114cc9207a44e3fad93c8798f515ccb